HealthDay News — Just over 1 in 10 adults aged 50 to 64 say they are very likely to participate in a dementia drug prevention trial, according to a study published online in the Journal of Prevention of Alzheimer’s Disease.

Chelsea G. Cox, from University of Michigan School of Public Health in Ann Arbor, and colleagues examined characteristics of US adults with self-reported likelihood to participate in dementia drug prevention clinical trials. Analysis included 1028 respondents (aged 50 to 64 years) to an online survey.

The researchers found that 12% of respondents reported being very likely to participate in a dementia prevention trial, 32% somewhat likely, and 56% not likely. Higher likelihood to participate was associated with higher perceived risk of dementia (odds ratio, 2.17), a positive family history of dementia (odds ratio, 1.75), and having discussed dementia prevention with a doctor (odds ratio, 2.20). Sociodemographic characteristics did not impact likelihood to participate. Among those indicating they were not likely to participate, 39% said they did not want to be a guinea pig, 23% thought dementia would not affect them, 22% thought there would be too high a chance for harm, 15% were concerned about how much time it would take, and 5% reported fear of learning information about oneself.


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“Findings suggest that recruitment interventions focused on increasing knowledge of dementia risk and prevention trials and involving health care providers may be effective tools to improve enrollment rates, regardless of target community,” the authors write.

Abstract/Full Text