HealthDay News — Telephone-based cognitive behavioral therapy (T-CBT) seems to be an effective intervention for depression in Parkinson disease (PD), outperforming treatment-as-usual (TAU) on all depression, anxiety, and quality-of-life measures, according to a study published online April 1 in Neurology.
Roseanne D. Dobkin, PhD, from Rutgers-Robert Wood Johnson Medical School in Piscataway, New Jersey, and colleagues examined the efficacy of a 10-session T-CBT intervention for depression in PD compared to TAU in a randomized controlled trial involving 72 patients with PD. T-CBT was tailored to the unique needs of patients with PD and was provided weekly for 3 months, then monthly during 6-month follow-up. CBT targeted negative thoughts and behaviors.
The researchers found that on all depression, anxiety, and quality-of-life measures, T-CBT outperformed TAU. By treatment end, the primary outcome (Hamilton Depression Rating Scale score) improved significantly in T-CBT vs TAU, with a mean improvement from baseline of 6.53 and −0.27 points, respectively; the gains persisted during 6 months of follow-up. In the T-CBT group only, improvements were moderated by a reduction in negative thoughts, reflecting treatment target engagement.
“While preliminary, these findings support the promise of telemedicine to expand the reach of evidence-based, PD-informed depression treatment, and its substantial benefits for PD self-management, into routine neurologic care,” the authors write.