HealthDay News — Hormone replacement therapy (HRT) use is associated with reduced odds of all-cause mortality among women with a recorded diagnosis of COVID-19, according to a study published in Family Practice.
Hajira Dambha-Miller, MRCGP, PhD, from the University of Southampton in the United Kingdom, and colleagues conducted a retrospective cohort study to examine the association between HRT or combined oral contraceptive pill (COCP) use and the likelihood of death among women with COVID-19. A cohort included 1,863,478 women older than 18 years from 465 general practices in England.
The researchers identified 5451 COVID-19 cases within the cohort. During the follow-up period (mean, 164.9 days), 12.2% of women died. Hormone replacement therapy was associated with a reduction in all-cause mortality in COVID-19 (adjusted odds ratio, 0.22). In women prescribed COCPs, there were no reported events for all-cause mortality, preventing further examination of the impact of COCPs.
“We found that HRT prescription within 6 months of a recorded diagnosis of COVID-19 infection was associated with a reduction in all-cause mortality,” the authors wrote. “From these results, women should be reassured that there is no indication to discontinue HRT use because of the pandemic.”