(HealthDay News) — For preschool children, overweight/obesity is associated with more asthma symptom days and exacerbations among those not treated with a daily controller, and inhaled corticosteroids (ICS) are associated with significant improvements among overweight/obese preschoolers, according to research published online Dec. 19 in the Journal of Allergy and Clinical Immunology.
Jason E Lang, MD, MPH, from the Duke University School of Medicine in Durham, NC, and colleagues examined the correlations between overweight/obesity and asthma severity and response to ICS in preschool children. Data were included from 3 large trials involving 2- to 5-year-old children, which compared annualized asthma symptom days and exacerbations among normal-weight and overweight/obese participants.
The researchers found that within the group not treated with a daily controller, overweight/obese children had significantly more asthma symptom days and exacerbations than normal-weight children. Overweight/obese and normal-weight children had similar asthma symptom days and exacerbations within the ICS-treated groups. In overweight/obese children, daily ICS vs placebo led to fewer annualized asthma symptom days and exacerbations, while similar protective ICS effects were less apparent in normal-weight children.
“In preschool children off controller therapy, overweight/obesity is associated with greater asthma impairment and exacerbations,” the authors write. “However, unlike older asthmatic patients, overweight/obese preschool children do not demonstrate reduced responsiveness to ICS therapy.”
Several authors disclosed financial ties to the pharmaceutical industry.
- Lang JE, Fitzpatrick AM, Mauger DT, et al. Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids. J Allergy Clin Immun. 2017 Dec 19. doi:10.1016/j.jaci.2017.09.043.