HealthDay News — Compounded topical pain creams are no better than placebo creams for neuropathic pain, nociceptive pain, or mixed pain, according to a study published online Feb. 5 in the Annals of Internal Medicine.

Robert E. Brutcher, PharmD, PhD, from the Walter Reed National Military Medical Center in Bethesda, Maryland, and colleagues examined the efficacy of compounded creams for chronic pain in a randomized controlled trial. A total of 399 patients with localized pain classified as neuropathic (133 patients), nociceptive (133 patients), or mixed (133 patients) were enrolled; within each pain category, the patients received compounded pain creams or placebo.

The researchers observed no differences in the mean reduction in average pain scores 1 month after treatment between the treatment and control groups for patients with neuropathic pain, nociceptive pain, or mixed pain (−0.1 points [95% confidence interval, −0.8 to 0.5 points], −0.3 points [95% confidence interval, −0.9 to 0.2 points], and −0.3 points [95% confidence interval, −0.9 to 0.2 points], respectively). There was also no difference between the treatment and control groups for all patients (−0.3 points; 95% confidence interval, −0.6 to 0.1 points). Thirty-six and 28% of patients in the treatment and control groups, respectively, had a positive outcome at 1 month (risk difference, 8%; 95% confidence interval, −1 to 17%).

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“Future studies should seek to determine whether targeting specific types of pain or adding other agents (such as dimethyl sulfoxide) would lead to better results,” the authors write.

Two authors disclosed financial ties to the pharmaceutical and medical device industries.

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