HealthDay News — There is little evidence supporting the efficacy of prophylactic pharmacologic treatments for pediatric migraine, according to a review published online Feb. 10 in JAMA Pediatrics.

Cosima Locher, PhD, from the University of Plymouth in England, and colleagues conducted a systematic literature review to identify clinical trials of prophylactic pharmacologic treatments in children and adolescents diagnosed as having episodic migraine.

Based on 23 identified studies (2217 patients), the researchers found that prophylactic pharmacologic treatments included antiepileptics, antidepressants, calcium channel blockers, antihypertensive agents, and food supplements. During the short term (less than 5 months), propranolol (standard mean difference, 0.60; 95% confidence interval [CI], 0.03 to 1.17) and topiramate (standard mean difference, 0.59; 95% CI, 0.03 to 1.15) were more effective than placebo. There were no significant long-term effects for migraine prophylaxis compared with placebo for any intervention.

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“Considering the limited effect size, a cautious, individual, and tailored treatment approach to migraine prophylaxis is of great importance,” the authors write.


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One author disclosed financial ties to the pharmaceutical industry.

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