Schizophrenia Information Center

Treatment-Resistant-Schizophrenia

Examining Rare Variant Risk Factors in Individuals With Schizophrenia

While extreme phenotype sequencing has brought about the identification of high-impact rare genetic variants for many complex disorders, this has yet to be tested in studies of severe schizophrenia. A total of 112 individuals with severe, extremely treatment resistant schizophrenia were sequenced and the burden of rare, damaging missense and loss-of-function variants between severe, extremely treatment-resistant schizophrenia, typical schizophrenia, and controls across mutation intolerant genes were compared.
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