HealthDay News — For patients undergoing knee replacement surgery, use of a tourniquet may increase the risk for serious adverse events, according to a review published online in the Cochrane Library.

Imran Ahmed, MB, ChB, PhD, from the University of Warwick in the United Kingdom, and colleagues examined the benefits and harms of tourniquet use in knee replacement surgery in a review of 41 randomized controlled trials with 2819 participants.

The researchers found that pain was ranked at 4.56 points after surgery without a tourniquet and at 1.25 points higher with a tourniquet at postoperative day 1 (absolute difference, 12.5% higher pain scores). Tourniquet use probably made little or no difference to function at 12 months, based on a minimal clinically important difference of 5.3 for the Knee Society Score and 5.0 for the Oxford Knee Score. After surgery without a tourniquet, mean function was 90.03 points and was 0.29 points worse with a tourniquet. Tourniquet use had little or no effect on success and little or no effect on quality of life. The risk for serious adverse events was probably higher with than without a tourniquet (59 vs 29 per 1,000 reported events following surgery; risk ratio, 1.73).

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“The evidence indicates that knee replacement surgery performed with a tourniquet increases the risk of serious complications needing additional health care, many of which might be avoided if a tourniquet is not used,” a coauthor said in a statement.

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