HealthDay News — Reducing intake of added fructose and other added sugars could reduce diabetes-related morbidity, results of an article published in the Mayo Clinic Proceedings indicated.

“Added fructose in particular (eg, as a constituent of added sucrose or as the main component of high-fructose sweeteners) may pose the greatest problem for incident diabetes, diabetes-related metabolic abnormalities, and CV risk,” noted James J. DiNicolantonio, PharmD, of Saint Luke’s Mid America Heart Institute in Kansas City, Mo., and colleagues.

In contrast, whole foods containing fructose do not pose problems for health and may be protective against diabetes and adverse cardiovascular outcomes. Although dietary guidelines recommend consumption of whole foods over foods with added sugars, some do not limit fructose-containing added sugars to any specific level.

Other guidelines (such as from the Institute of Medicine) permit 25% of calories as fructose-containing added sugars. Reducing intake to 5% of calories, the level recommended by the World Health Organization, can improve glucose tolerance in humans and reduce the prevalence of diabetes and associated complications, according to the authors.

“Reducing the intake of added sugars could translate to reduced diabetes-related morbidity and premature mortality for populations,” concluded the researchers.


  1. DiNicolantonio JJ et al. Mayo Clinic Proceedings. 2015; doi: