HealthDay News — Anxiety and depression are linked to increased severity of retrosternal pain and heartburn and reduced quality of life among patients with gastroesophageal reflux disease, according to a study published in Clinical Gastroenterology and Hepatology.

To investigate the effects of anxiety and depression gastroesophageal reflux disease (GERD), Boudewijn F. Kessing, MD, of the Academic Medical Center Amsterdam, and colleagues conducted a prospective study involving 225 patients who underwent evaluation of GERD symptoms.

GERD was diagnosed in 147 patients; 78 had functional heartburn. Thirty-six patients were found to be hypersensitive to gastroesophageal reflux. Increased levels of anxiety correlated with more severe retrosternal pain and retrosternal burning among patients with GERD.

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There were also correlations for increased levels of anxiety and depression with lower scores of the mental component of the quality of life questionnaire. There was no association for levels of anxiety or depression with the number of reflux symptoms reported during 24-hour pH impedance monitoring or with the number of symptoms associated with a reflux event. Levels of anxiety and depression and decreases in quality of life were similar for GERD patients with hypersensitivity to reflux.

“In patients with GERD, increased levels of anxiety are associated with increased severity of retrosternal pain and heartburn and reduced quality of life,” concluded the researchers.


  1. Kessing BF et al. Clinical Gastroenterology and Hepatology. 2015; doi: