HealthDay News — To minimize the risk of diabetes in Japanese men with visceral fat accumulation and hemoglobin A1C of 5.6% to 6.4%, patients must lose 4% to 5% of their body weight, results of a study published in the Journal of Diabetes Investigation indicate.
To quantify the amount of weight reduction necessary for minimizing of diabetes risk in Japanese men with visceral fat accumulation, Hiromi Iwahashi, MD, of Osaka University in Japan, and colleagues examined 482 male patients with estimated visceral fat area of >100 cm²; A1C of 5.6% to 6.4%; fasting plasma glucose of <126 mg/dL; or casual plasma glucose of <200 mg/dL.
The cumulative incidence of diabetes was 16.2% and 10.1% in the weight-gain and weight-loss groups, respectively, at the end of three years. Compared with the weight-gain group, the incidence of diabetes was significantly lower in the highest quartile weight-loss group (≥4.3% weight loss; 3.1%), but not in the second highest, second lowest, or lowest weight-loss groups (9.7%, 10.1%, and 18.3%, respectively).
“Minimization of the risk of diabetes in Japanese men with visceral fat accumulation requires a minimum of 4 to 5 percent weight loss in those with A1C of 5.6% to 6.4%,” concluded the authors.