HealthDay News — Early-life adversities such as childhood abuse may contribute to metabolic abnormalities that lead to obesity later in life, according to research published online in the Journal of Clinical Endocrinology & Metabolism.
Kyoung Eun Joung, MD, of Harvard Medical School in Boston, and colleagues analyzed blood samples from 95 adults to evaluate the association between early life adversity and circulating levels of adipomyokines, such as adiponectin, irisin and leptin, as well as the inflammatory marker C-reactive protein (CRP). Early-life adversity was defined as neglect or physical, emotional and/or sexual abuse, before age 18 years.
The researchers found that circulating levels of leptin (P<0.001), irisin (P=0.01) and CRP (P=0.02) were significantly higher among individuals in the highest tertile for early-life adversity compared with those in the low and middle tertile groups.
Adiponectin levels were lower in the highest tertile for early-life adversity (P=0.03) compared with those in the low and middle tertiles.
Following multivariable adjustment, the associations for leptin and irisin levels did not change, but adiponectin and CRP levels were no longer significantly associated with early-life adversity.
“Leptin and irisin likely play an important role in the pathogenesis of obesity and regulation of adiposity in individuals with early life adversities,” the authors write.