HealthDay News — Diabetes, obesity, hypertension are among risk factors for chronic kidney disease (CKD) that can be detected 20 to 30 years prior to CKD diagnosis, according to researchers.

After assessing CKD risk factors among matched patients with incident CKD (estimated glomerular filtration rate, ≤60 ml/min/1.73 m²) and patients without CKD, Gearoid M. McMahon, MB, BCh, of the National Heart, Lung, Blood Institute’s Framingham Heart Study in Massachusetts, and colleagues reported that some risk factors were present in patients well before CKD diagnosis. Their findings were reported in the Journal of the American Society of Nephrology.

Of the patients, 441 new diagnoses of CKD were identified and matched to 882 controls (mean age, 69.2 years; 52.4% women). Hypertension (odds ratio, 1.76), obesity (OR, 1.71), and higher triglycerides (OR, 1.43) were more likely to be present 30 years before CKD diagnosis in those who ultimately developed CKD.

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Additionally, patients who ultimately developed CKD were more likely to have hypertension (OR, 1.38), higher triglyceride levels (OR, 1.35), lower high-density lipoprotein cholesterol (OR, 0.89), and diabetes (OR, 2.90) 20 years before CKD diagnosis.

“These findings demonstrate that risk factors for CKD are identifiable ≥30 years before diagnosis and suggest the importance of early risk factor identification in patients at risk of CKD,” wrote the researchers.


  1. McMahon G et al. Journal of the American Society of Nephrology. 2014; doi: 10.1681/ASN.2013070750