HealthDay News — Split-dose regimens increase the quality of colon cleansing compared to day-before colonoscopy preparation, according to a review and meta-analysis published in the July issue of Gastroenterology.
Myriam Martel, from McGill University in Montreal, and colleagues conducted a systematic literature review to identify randomized trials that assessed the efficacy of bowel cleansing for split-dose regimens versus day-before colonoscopy preparation. Studies evaluating pediatric, hospitalized, or inflammatory bowel disease patients were excluded.
Based on 47 trials (13,487 patients), the researchers found that split-dose preparations provided significantly better colon cleansing than day-before preparations (odds ratio [OR], 2.51). This comparison included day-before preparations with polyethylene glycol (OR, 2.60), sodium phosphate (OR, 9.34), or picosulfate (OR, 3.54). A higher proportion of patients were willing to repeat split-dose versus day-before cleansing (OR, 1.90), as well as low-volume split-dose preparations versus high-volume split-dose preparations (OR, 4.95). The different preparation methods did not vary with regards to side effects, complications, or outcomes of procedures.
Continue Reading
“Additional research is required to evaluate oral sulfate solution-based and polyethylene glycol low-volume regimens further,” the authors write.
One author disclosed financial ties to the medical device industry.
