HealthDay News — The risk of developing type 1 diabetes is increased for children diagnosed with enterovirus (EV) infection, results of a study published in Diabetologia indicate.

“Despite more than 40 years of research, the role of EVs in type 1 diabetes is far from established; chief obstacles stem from difficulty in obtaining pancreatic tissue from patients,” explained Hsiao-Chuan Lin, of China Medical University in Taiwan, and colleagues.

To compare diabetes incident rates in children aged less than 18 years with or without a diagnosis of enterovirus from 2000 to 2008, the investigators used insurance claims data from Taiwan’s National Health Insurance research.

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The overall incidence of type was diabetes was 5.73 per 100,000 person-years in the enterovirus infection cohort and 3.89 per 100,000 person-years in the non-enterovirus infection cohort (incidence rate ratio, 1.48; adjusted hazard ratio, 1.48).

With the exception of patients aged five to 10 years, the rate of incidence increased with age at diagnosis of enterovirus infection. Children with allergic rhinitis, bronchial asthma, or either one of these atopic diseases showed more variation in the hazard ratios of type 1 diabetes compared with patients without the disease.

“The results suggest that a preventive strategy, such as an effective vaccine against enterovirus infection, may lessen the incidence of type 1 diabetes,” concluded the researchers.


  1. Hsiao-Chuan L et al. Diabetologia. 2014; doi: 10.1007/s00125-014-3400-z