HealthDay News — Financial concerns and parental attitudes are among the top barriers to human papillomavirus (HPV) vaccination in U.S. adolescents, according to researchers.

“Barriers faced by healthcare professionals and parents should be carefully considered when developing strategies to improve HPV vaccine uptake and completion,” Dawn M. Holman, MPH, from the CDC in Atlanta, and colleagues reported in JAMA Pediatrics.

They performed a systematic review of the literature describing barriers to HPV vaccination among U.S. adolescents and summarized findings by target population from 55 relevant articles.

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Parents frequently reported the need for more information before deciding to vaccinate their children, the researchers found. Potential barriers among parents also included concerns about the vaccine’s impact on sexual behavior, low perceived HPV infection risk, social influences, irregular preventive care and vaccine cost.

The perceived lack of direct benefit was reported as a reason by some parents for not vaccinating their sons. One of the most important factors in parents’ decisions to vaccinate their children was healthcare professional recommendations.

“Ultimately, efforts to better understand and address system-level barriers and social determinants of vaccination could potentially increase HPV vaccine uptake and completion among all U.S. adolescents,” the researchers concluded.


  1. Holman DM et al. JAMA Pediatr. 2013; doi:10.1001/jamapediatrics.2013.2752.