HealthDay News — Helicobacter pylori infection may affect the severity of psoriasis, according to a study published in the International Journal of Dermatology.
“Data from the literature concerning the role of Helicobacter pylori (H. pylori) infection in psoriasis are still conflicting,” noted Anna Campanati, MD, of Polytechnic Marche University in Ancona, Italy, and colleagues.
To evaluate the prevalence of H. pylori in patients with mild to severe psoriasis, correlation between H. pylori infection and severity of psoriasis, and effect of H. pylori eradication on the clinical course of psoriasis, the investigators followed 210 patients with psoriasis and 150 healthy controls.
The participants were screened for H. pylori through urea breath test at baseline. All patients with psoriasis received standardized phototherapy treatment, and those infected by H. pylori were also treated with a 1-week triple therapy, then they were all re-evaluated four weeks later at the end of therapy.
The prevalence of H. pylori was not higher in psoriasis versus the control group (20.27% and 22%, respectively; P>0.05), but patients infected with H. pylori showed more severe psoriasis compared with uninfected patients (psoriasis area and severity index score: 17.9% versus 13.7%; P=0.04).
Patients who were successfully treated for H. pylori infection showed a greater psoriasis improvement, compared to the others (psoriasis area and severity index score at the end of four weeks of therapy: 8.36% versus 10.85%; P=0.006).
“Patients with mild to severe psoriasis do not show a greater prevalence of H. pylori infection; however, H. pylori seems able to affect the clinical severity of psoriasis,” concluded the researchers.