HealthDay News — For frail, senior patients in nursing homes, a high-dose influenza vaccine produces a stronger immune response compared with a standard vaccine, results of a study published in the Journal of Infectious Diseases indicate.

Residents in long-term care facilities remain at high risk of influenza, despite vaccination, noted David A. Nace, MD, MPH, of the University of Pittsburgh, and colleagues. “More-effective vaccine options for this population are needed,” added the investigators.

To compare the high-dose and standard vaccines in seniors living in long-term care facilities, the researchers conducted a single-blinded, randomized control test with 205 senior nursing home residents from 2011 to 2013. Hemagglutination inhibition (HI) antibody titers were measured at baseline and 30 and 180 days following vaccination.

The high-dose vaccine prompted a modest but stronger improvement in the immune response to all but one flu strain at 30 days and 180 days after vaccination.

“For frail older adults, the high-dose vaccine appears to be a better option to protect against flu than the standard dose,” Nace, said in an Infectious Diseases Society of America news release.

“Even in the frail, long-term care population, the high-dose flu vaccine looks like it produces a greater antibody response than the standard-dose vaccine.”


  1. Nace DA. J Infectious Dis. 2014; doi: 10.1093/infdis/jiu622


The study was funded in part by Sanofi Pasteur; several authors disclosed financial ties to Sanofi Pasteur.