HealthDay News — Insulin resistance does not appear to be a significant factor in post-adolescent acne, according to a study published in the International Journal of Dermatology.

Post-adolescent acne has been defined as acne in patients aged 25 years and older. During puberty, there is a transient decline in insulin sensitivity, noted Ilknur Balta, M.D., from the Ministry of Health in Ankara, Turkey, and colleagues.

To investigate the relationship between post-adolescent acne and insulin resistance, the researchers followed 35 patients with post-adolescent acne and 35 healthy controls.

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Fasting blood glucose, fasting insulin, aspartate aminotransferase, alanine aminotransferase, triglyceride and high-density lipoprotein cholesterol levels, and the homeostasis model assessment of insulin resistance index did not differ significantly for patients with post-adolescent acne and controls, found the investigators. No correlations were seen for these parameters with acne severity.

“This study suggests that insulin resistance may not play a major role in the pathogenesis of post-adolescent acne,” concluded the scientists.

“Hormonal changes, genetic susceptibility, stress, the use of cosmetics, drugs, and environmental factors should be considered in the development of post-adolescent acne.”


  1. Balta I et al. International Journal of Dermatology. 2015; doi: 10.1111/ijd.12426.