HealthDay News — Problematic symptoms of prostate biopsy can lead to increased anxiety in men, even when the biopsy results are negative for cancer, study results suggest.

“Problematic post-biopsy symptoms can lead to increased anxiety, distinct from distress related to diagnosis of prostate cancer,” Julia Wade, PhD, of the University of Bristol in the United Kingdom, and colleagues reported in the Journal of Clinical Oncology. “Men and doctors need to consider these additional potential harms of biopsy when deciding whether to initiate prostate-specific antigen testing.”

The researchers analyzed data from questionnaires completed by 1,144 men enrolled in the Prostate Testing for Cancer and Treatment trial to assess the psychological impact of prostate biopsy.

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The researchers found that biopsy-related symptoms were minor or not a problem, and overall levels of anxiety and depression were low, for most men.

Among 471 men who received a negative biopsy result, those who had biopsy-related symptoms at seven days that were problematic — pain, shivers, hematuria, hematochezia and hemoejaculate — had significantly greater anxiety than those who had symptoms that were non-problematic.

At 35 days, although symptoms were not reduced, anxiety was lessened.


  1. a href=”” target=”_new”>Wade J et al. J Clin Onc. 2013; doi:10.1200/JCO.2012.45.4801.