HealthDay News — Although there is some evidence to suggest that maternal influenza, prolonged febrile episodes and antibiotic use during pregnancy may be associated with an increased risk of autism spectrum disorder (ASD)/infantile autism, further research is required to elucidate these associations, a recent study suggests.

Hjördis Ósk Atladóttir, MD, PhD, of the University of Aarhus in Denmark, and colleagues conducted a population-based cohort study of 96,736 children aged 8 to 14 years to examine whether common infections, febrile episodes, and antibiotic use during pregnancy affected the risk of ASD and infantile autism.

The researchers found little evidence that mild common infectious diseases or febrile episodes during pregnancy correlated with ASD or infantile autism, they reported in Pediatrics.

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However, the risk of infantile autism was increased two-fold with maternal influenza infection, and three-fold with prolonged episodes of fever. In addition, use of various antibiotics was suggested as a risk factor for ASD/infantile autism.

“Our results do not suggest that mild infections, febrile episodes, or use of antibiotics during pregnancy are strong risk factors for ASD and infantile autism. Due to multiple testing, the few statistically significant findings were possible chance findings,” the researchers wrote. “We experienced several methodologic limitations, and the results of this study thus cannot solely negate a possible association. We emphasize the need for further research on this important topic.”


  1. Atladóttir HO et al. Pediatrics. 2012; doi: 10.1542/peds. 2012-1107.