HealthDay News — Extremely obese adolescents in an intensive 10-month residential treatment program lost more weight compared with their counterparts, and appeared to reverse endothelial dysfunction that could lead to atherosclerosis, results of a study in Pediatrics indicate.

To investigate the influence of a multicomponent treatment on microvascular function, Luc Bruyndonckx, MD, PhD, of the University of Antwerp/Antwerp University Hospital, and colleagues tracked 24 girls and nine boys, aged an average of 15 years, for 10 months while they lived in a residential weight-loss facility. The researchers also tracked 28 similarly obese adolescents who were encouraged to reduce calories and exercise at home.

By the end of the 10-month study, six children dropped out of the residential intervention and seven dropped out of the usual-care group. The children in the program were only allowed to eat 1,500 to 1,800 calories a day. They also had to participate in physical activity every day and get mental health support.

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The obese children in the intervention program lost about 60 pounds. Meanwhile, children who received standard diet and exercise counseling gained more than 16 pounds. Weight, body fat levels, cholesterol levels, and blood pressure all improved in the children who took part in the residential program. Microvascular endothelial function also improved in the intervention group at 10 months.

“A treatment regimen consisting of supervised diet and exercise training was effective in improving multiple adolescent obesity-related end points,” concluded the investigators.


  1. Bruyndonckx L et al. Pediatrics. 2015; doi: 10.1542/peds.2014-1577