HealthDay News — An association between teenage acne and melanoma has been found, results of a study published in Cancer indicate.
“Acne reflects hormone imbalance and is a key component of several systemic diseases,” noted Mingfeng Zhang, MD, PhD, of the Brigham and Women’s Hospital in Boston, and colleagues.
To test if a diagnosis of acne as a teenager might predict subsequent risk of hormone-related cancers, the investigators followed 99,128 female nurses enrolled in the Nurses’ Health Study II cohort for 20 years.
Among women with a history of severe teenage acne, the relative risk increased for melanoma after adjustment for previously known risk factors for each cancer, with a multivariable-adjusted hazard ratio of 1.44.
In an independent melanoma case-control study involving 930 cases and 1,027 controls, the association was replicated (multivariable-adjusted odds ratio, 1.27). In both studies, those with teenage acne were more likely to have moles (52.7% versus 50.1% in the cohort study; 55.2% versus 45.1% in the case-control study).
“Our findings suggest that a history of teenage acne might be a novel risk factor for melanoma independent from the known factors, which supports a need for continued investigation of these relationships,” concluded the study authors.