HealthDay News — Risks associated with routine vaccinations for children are rare, according to a review published in Pediatrics.

“Despite their effectiveness in preventing and eradicating disease, routine childhood vaccine uptake remains suboptimal, ” wrote Margaret A. Maglione, MPP, of the RAND Corporation in Santa Monica, Calif., and colleagues. 

“Parental refusal of vaccines has contributed to the outbreaks of vaccine-preventable diseases such as measles and pertussis.”

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In July 2014, we asked the readers to gauge their experience with vaccinations for children. Here’s what you had to say:

Clinical Advisor Poll Results

Investigators conducted a systemic review of the literature on the safety of routine vaccines recommended for children in the United States. They abstracted adverse events and patient and vaccine characteristics, and evaluated adverse event collection and reporting using the McHarm scale in 67 studies, but results could not be pooled.

There was high-strength evidence for an association between the MMR vaccine and febrile seizures, and high-strength evidence to indicate that MMR vaccine was not associated with autism. Strong evidence also supported the association between the varicella vaccine and complications in immunodeficient individuals. Moderate evidence indicated that rotavirus vaccines correlate with intussusception.

Most studies did not investigate or identify risk factors for adverse events, and there were inconsistent reports on the severity of adverse events.

“We found evidence that some vaccines are associated with serious adverse events; however, these events are extremely rare and must be weighed against the protective benefits that vaccines provide,” wrote the researchers.


  1. Pediatrics. 2014; doi: 10.1542/peds.2014-1079