Medications

Folic Acid Supplementation May Protect Against Language Delay in AED-Exposed Children

Folic Acid Supplementation May Protect Against Language Delay in AED-Exposed Children

The odds of language delay were lower at 18 months and 36 months in children exposed to AEDs in utero whose mothers took folic acid.

Single, Fixed-Dose Combo Pills Improve Hypertension Outcomes

Single, Fixed-Dose Combo Pills Improve Hypertension Outcomes

Findings show improved outcomes may be due to better medication adherence.

Benefits of NSAIDs as Part of Multimodal Analgesia Regimen in Children

Benefits of NSAIDs as Part of Multimodal Analgesia Regimen in Children

Perioperative and emergency department use of non-steroidal anti-inflammatory drugs as part of a multimodal analgesia regimen may improve pain control in pediatric populations and avoid opioid-related adverse events.

Emicizumab Prophylaxis Cuts Bleeding in Hemophilia A

Emicizumab Prophylaxis Cuts Bleeding in Hemophilia A

Lower bleeding rate with administration once weekly, every 2 weeks vs no prophylaxis.

Hydrocodone Schedule Change Affected Post-Op Opioid Rx

Hydrocodone Schedule Change Affected Post-Op Opioid Rx

Increase in mean OMEs filled in initial opioid rx after hydrocodone's change from schedule III to II.

Testing the Current Guidelines for Antidepressant Treatment of New Onset Depression

Testing the Current Guidelines for Antidepressant Treatment of New Onset Depression

Investigators determined that titrating sertraline to 100 mg/day vs 50 mg/day for initial antidepressant therapy for a new MDD episode has no added benefit and increases cost.

Prevalence of Antimicrobial-Contraindicated Drug Combo Prescribing Examined

Prevalence of Antimicrobial-Contraindicated Drug Combo Prescribing Examined

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Researchers performed a cross-sectional study that included multiple year pooled data (2003 to 2011) from the National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Medical Care Survey (NHAMCS Outpatient Department).

Triple Combo Blood Pressure Pill Can Improve BP Control

Triple Combo Blood Pressure Pill Can Improve BP Control

Proportion achieving target BP increased with use of triple combo pill vs usual care at 6 months.

Daily BCX7353 Cuts Rate of Hereditary Angioedema Attacks

Daily BCX7353 Cuts Rate of Hereditary Angioedema Attacks

Oral administration of BCX7353 at dose of 125 mg results in lower rate of attacks vs placebo.

Aspirin, Non-Aspirin NSAID Use May Improve Survival Outcomes in Ovarian Cancer

Aspirin, Non-Aspirin NSAID Use May Improve Survival Outcomes in Ovarian Cancer

Previous studies have suggested that analgesic medicine use may have a protective effect for patients with ovarian cancer.

Chemotherapy With Bevacizumab May Improve Some Ovarian Cancer Outcomes, Worsen Others

Chemotherapy With Bevacizumab May Improve Some Ovarian Cancer Outcomes, Worsen Others

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First-line chemotherapy in combination with bevacizumab, compared with chemotherapy alone, may benefit patients with ovarian cancer and elevated neutrophil-to-lymphocyte ratios.

Blister Packs for Several Meds Recalled Due to Risk of Harm to Children

Blister Packs for Several Meds Recalled Due to Risk of Harm to Children

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The recall affects approximately 470,000 units that include drugs packaged with 3 to 10 tablets per blister card. The blister packs were developed for use in hospitals, however some were sent to retail pharmacies and were likely dispensed for in-home use.

Beta-Blockers Show Varied Effects on Hypoglycemic Mortality Risk in Diabetes

Beta-Blockers Show Varied Effects on Hypoglycemic Mortality Risk in Diabetes

Investigators examined the relationship between the use of β-blockers and incidence of hypoglycemia and risk for mortality in hospitalized patients with diabetes.

AMA: Docs Declare Drug Shortages Public Health Emergency

AMA: Docs Declare Drug Shortages Public Health Emergency

AMA calls for greater manufacturer transparency in order to prepare for disasters, mitigate shortages.

Post-Op Pain Treatment Gets Breakthrough Therapy Designation

Post-Op Pain Treatment Gets Breakthrough Therapy Designation

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The Company indicated that they will work towards an New Drug Application submission for the treatment in the second half of 2018.

NSAID Use May Increase CVD Risk in Osteoarthritis

NSAID Use May Increase CVD Risk in Osteoarthritis

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Nonsteroidal anti-inflammatory drug use mediated a substantial amount of cardiovascular disease risk in osteoarthritis.

Depression an Adverse Effect in One-Third of Prescription Medications

Depression an Adverse Effect in One-Third of Prescription Medications

Prevalence of depression higher for adults reporting use of multiple meds with depression as side effect

No Additional Benefits With Vaginal Estradiol Tablets, Moisturizers for Postmenopausal Vulvovaginal Symptoms

No Additional Benefits With Vaginal Estradiol Tablets, Moisturizers for Postmenopausal Vulvovaginal Symptoms

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Prescribed vaginal estradiol tablets and over-the-counter vaginal moisturizers may not be more effective than placebos for postmenopausal vulvovaginal symptoms.

Long-Term Antidepressant Use Linked to Weight Gain

Long-Term Antidepressant Use Linked to Weight Gain

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The broad use of antidepressants among the general population may be linked to weight gain.

Naloxone Recalled Due to Potential Health Risks

Naloxone Recalled Due to Potential Health Risks

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Two lots of naloxone hydrochloride injections, USP have been recalled by Hospira, Inc., due to concerns regarding the presence of particulates on the syringe plunger.

Studies ID Impact of US Opioid-Related Mortality, Prescription Patterns

Studies ID Impact of US Opioid-Related Mortality, Prescription Patterns

Burden of deaths up; most patients receiving opioid analgesics use immediate-release formulations

When Antidepressants Fail, Dose Increase May Be a Less Effective Response

When Antidepressants Fail, Dose Increase May Be a Less Effective Response

As this and previous research on dose increase strategies have produced inconsistent findings, the researchers recommended clinicians consider other responses to antidepressant treatment failure, at least for selective serotonin reuptake inhibitors.

Prescription Medication Use Decreasing in Children, Adolescents

Prescription Medication Use Decreasing in Children, Adolescents

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Estimates of prescription medication use in children and adolescents showed an overall decrease in use of any medication from 1999 to 2014.

Managing Pediatric Migraine: Current Therapies and Future Directions

Managing Pediatric Migraine: Current Therapies and Future Directions

Migraine is highly prevalent in children and adolescents, affecting almost 10% of children between 5 and 15 years old and 30% of adolescents between 15 and 19 years old.

Pharmaceutical Marketing Associated With Increased Opioid Prescription Rates

Pharmaceutical Marketing Associated With Increased Opioid Prescription Rates

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Payments correlated with prescribing opioids in 2014 may have influenced the increased prescription rates of 2015.

Some Anticholinergic Drugs May Be Linked to Dementia

Some Anticholinergic Drugs May Be Linked to Dementia

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Anticholinergic drugs for depression, urologic conditions, or Parkinson disease are associated with potential dementia occurrences up to 20 years after drug exposure.

Unit-Dose Packaging Cuts Accidental Peds Opioid Exposures

Unit-Dose Packaging Cuts Accidental Peds Opioid Exposures

Relative decrease in buprenorphine-naloxone exposure after transition to unit-dose packaging

Intrathecal Drug Delivery and Spinal Cord Stimulation for Cancer Pain: A Review

Intrathecal Drug Delivery and Spinal Cord Stimulation for Cancer Pain: A Review

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Intrathecal drug delivery systems and spinal cord stimulation have shown promise for the treatment of cancer pain in initial studies.

Study Finds 31% Use No Opioids After Surgery

Study Finds 31% Use No Opioids After Surgery

At discharge, 92.2% of patients received an opioid prescription; nearly 63% unused

Diabetes and Mortality: Comparing SGLT-2 Inhibitors, GLP-1 Agonists, and DPP-4 Inhibitors

Diabetes and Mortality: Comparing SGLT-2 Inhibitors, GLP-1 Agonists, and DPP-4 Inhibitors

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For patients with type 2 diabetes, sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 agonists significantly reduce mortality rates compared with dipeptidyl peptidase 4 inhibitors.

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