Medications

Depression an Adverse Effect in One-Third of Prescription Medications

Depression an Adverse Effect in One-Third of Prescription Medications

Prevalence of depression higher for adults reporting use of multiple meds with depression as side effect

No Additional Benefits in Vaginal Estradiol Tablets, Moisturizers for Postmenopausal Vulvovaginal Symptoms

No Additional Benefits in Vaginal Estradiol Tablets, Moisturizers for Postmenopausal Vulvovaginal Symptoms

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Prescribed vaginal estradiol tablets and over-the-counter vaginal moisturizers may not be more effective than placebos for postmenopausal vulvovaginal symptoms.

Long-Term Antidepressant Use Linked to Weight Gain

Long-Term Antidepressant Use Linked to Weight Gain

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The broad use of antidepressants among the general population may be linked to weight gain.

Naloxone Recalled Due to Potential Health Risks

Naloxone Recalled Due to Potential Health Risks

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Two lots of naloxone hydrochloride injections, USP have been recalled by Hospira, Inc., due to concerns regarding the presence of particulates on the syringe plunger.

Studies ID Impact of US Opioid-Related Mortality, Prescription Patterns

Studies ID Impact of US Opioid-Related Mortality, Prescription Patterns

Burden of deaths up; most patients receiving opioid analgesics use immediate-release formulations

When Antidepressants Fail, Dose Increase May Be a Less Effective Response

When Antidepressants Fail, Dose Increase May Be a Less Effective Response

As this and previous research on dose increase strategies have produced inconsistent findings, the researchers recommended clinicians consider other responses to antidepressant treatment failure, at least for selective serotonin reuptake inhibitors.

Prescription Medication Use Decreasing in Children, Adolescents

Prescription Medication Use Decreasing in Children, Adolescents

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Estimates of prescription medication use in children and adolescents showed an overall decrease in use of any medication from 1999 to 2014.

Managing Pediatric Migraine: Current Therapies and Future Directions

Managing Pediatric Migraine: Current Therapies and Future Directions

Migraine is highly prevalent in children and adolescents, affecting almost 10% of children between 5 and 15 years old and 30% of adolescents between 15 and 19 years old.

Pharmaceutical Marketing Associated With Increased Opioid Prescription Rates

Pharmaceutical Marketing Associated With Increased Opioid Prescription Rates

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Payments correlated with prescribing opioids in 2014 may have influenced the increased prescription rates of 2015.

Some Anticholinergic Drugs May Be Linked to Dementia

Some Anticholinergic Drugs May Be Linked to Dementia

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Anticholinergic drugs for depression, urologic conditions, or Parkinson disease are associated with potential dementia occurrences up to 20 years after drug exposure.

Unit-Dose Packaging Cuts Accidental Peds Opioid Exposures

Unit-Dose Packaging Cuts Accidental Peds Opioid Exposures

Relative decrease in buprenorphine-naloxone exposure after transition to unit-dose packaging

Intrathecal Drug Delivery and Spinal Cord Stimulation for Cancer Pain: A Review

Intrathecal Drug Delivery and Spinal Cord Stimulation for Cancer Pain: A Review

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Intrathecal drug delivery systems and spinal cord stimulation have shown promise for the treatment of cancer pain in initial studies.

Study Finds 31% Use No Opioids After Surgery

Study Finds 31% Use No Opioids After Surgery

At discharge, 92.2% of patients received an opioid prescription; nearly 63% unused

Diabetes and Mortality: Comparing SGLT-2 Inhibitors, GLP-1 Agonists, and DPP-4 Inhibitors

Diabetes and Mortality: Comparing SGLT-2 Inhibitors, GLP-1 Agonists, and DPP-4 Inhibitors

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For patients with type 2 diabetes, sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 agonists significantly reduce mortality rates compared with dipeptidyl peptidase 4 inhibitors.

Epilepsy Associated With Increased Risk of Unnatural Death

Epilepsy Associated With Increased Risk of Unnatural Death

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Patients with epilepsy have a greater risk of unnatural mortality than individuals without the disorder and should take greater precautions when taking certain medications.

Switching from Branded to Authorized Generic Drugs Linked to Lower Switchback Rate

Switching from Branded to Authorized Generic Drugs Linked to Lower Switchback Rate

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Switching back to branded drugs is more likely in generic drug than authorized generic drugs.

Infant Use of Acid-Suppressants, Antibiotics Tied to Allergic Disease Development

Infant Use of Acid-Suppressants, Antibiotics Tied to Allergic Disease Development

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Some allergic diseases associated with acid-suppressive, antibiotic intake in infants younger than 6 months old include food allergies, anaphylaxis, asthma, and allergic rhinitis.

Fycompa sNDA Submitted for Pediatric Seizure Indications

Fycompa sNDA Submitted for Pediatric Seizure Indications

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The proposed pediatric indications are based on a 2018 Draft Guidance that supports extrapolating efficacy data of approved drugs to treat POS in adults to pediatric patients aged ≥4 years.

Pediatric Asthma Unaffected by 5-fold Increased Inhaled Glucocorticoid Dose

Pediatric Asthma Unaffected by 5-fold Increased Inhaled Glucocorticoid Dose

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Increasing inhaled glucocorticoid doses at initial signs of exacerbating asthma may not be effective.

Daily dose of PrEP raises coverage, protective drug concentrations

Daily dose of PrEP raises coverage, protective drug concentrations

Recommendations for daily doses of emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) resulted in protective drug concentrations for men and transgender women.

Assessing lidocaine efficacy for chronic pain management

Assessing lidocaine efficacy for chronic pain management

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Intravenous, patch lidocaine might be effective in treating, preventing chronic pain.

Delayed treatment after epileptic seizure onset leads to higher mortality rate

Delayed treatment after epileptic seizure onset leads to higher mortality rate

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Ill-timed administration of benzodiazepine treatment in pediatric patients with refractory convulsive status epilepticus is associated with many short-term adverse events.

Walmart releases an opioid disposal solution

Walmart releases an opioid disposal solution

DisposeRx is a free method to safely and responsibly dispose of prescription opioids.

Postoperational opioid misuse linked to prescription longevity

Postoperational opioid misuse linked to prescription longevity

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Duration, more than dosage, may increase the risk of misuse in opioid naïve patients.

Shorter pediatric tuberculosis treatment linked to higher completion rates

Children with tuberculosis who received 3 months of directly observed preventative therapy were 25 times more likely to complete their treatment regimen than those who received 9 months of self-administered therapy.

Combination ART may prevent progressive brain injury in HIV patients

Combination ART may prevent progressive brain injury in HIV patients

Post-seroconversion brain morphology can occur in HIV patients, but aviremia maintenance via cART can slow of prevent brain injuries.

Oral capsule of fecal transplant may be effective for <i>C. difficile</i> infection

Oral capsule of fecal transplant may be effective for C. difficile infection

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Oral capsule FMT and colonoscopy delivery showed similar patient outcomes, low rate differences, and high success rates.

Certain medication use associated with dry mouth in older adults

Certain medication use associated with dry mouth in older adults

Medication use is significantly associated with xerostomia and salivary gland dysfunction in older adults.

An alarm clock can help patients remember to take their medication

An alarm clock can help patients remember to take their medication

Patients shouldn't turn off the alarm until their medication has been taken.

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