Major Depression in Males May Lower Chances of Conception

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Active major depression in women not associated with negative fertility outcomes.
Active major depression in women not associated with negative fertility outcomes.

HealthDay News — Active major depression in the male partner may lower the likelihood of pregnancy, according to a study published in the May issue of Fertility & Sterility.

Emily A. Evans-Hoeker, MD, from Virginia Tech Carilion in Roanoke, and colleagues assessed whether maternal major depression, antidepressant use, or paternal major depression are associated with pregnancy outcomes after non-IVF fertility treatments among 1650 women and 1608 men.

The researchers found that among women not using an antidepressant, having currently active major depression was not associated with poorer fertility outcomes (live birth, miscarriage), but rather there was a slightly increased likelihood of pregnancy. Among the 90 women using antidepressants, there was an increased risk of miscarriage. Male partners with currently active major depression were less likely to achieve conception.

"Currently active major depression in the female partner does not negatively affect non-in vitro fertilization treatment outcomes; however, currently active major depression in the male partner may lower the likelihood of pregnancy," write the authors.

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