Neurocognitive Disorders

Critical Illness and the Brain: Managing Risk for Cognitive Adverse Effects

Critical Illness and the Brain: Managing Risk for Cognitive Adverse Effects

The results highlight the importance of evaluating and monitoring cognitive function in individuals with recent critical illness or major infections, especially if they are already at risk for dementia.

New Diagnostic Criteria for Neurosarcoidosis: What You Need to Know

New Diagnostic Criteria for Neurosarcoidosis: What You Need to Know

The new guidelines will facilitate the design and development of clinical trials to test new therapies to minimize the burden of neurologic disability produced by neurosarcoidosis.

Alzheimer Disease Biomarkers Expose Individuals to Long-Term Care Insurance Denial

Alzheimer Disease Biomarkers Expose Individuals to Long-Term Care Insurance Denial

Approximately 5.5 million Americans have Alzheimer disease or dementia.

Multiple System Atrophy: A Common Form of Atypical Parkinsonism

Multiple System Atrophy: A Common Form of Atypical Parkinsonism

Multiple system atrophy is a rare, progressive neurodegenerative condition for which there is currently no cure.

Cataract Surgery Tied to Drop in Cognitive Decline in Seniors

Cataract Surgery Tied to Drop in Cognitive Decline in Seniors

Decline in episodic memory scores seen with older age slower after vs before cataract surgery.

Exercise May Delay Symptoms of Alzheimer's in Those at Risk

Exercise May Delay Symptoms of Alzheimer's in Those at Risk

Findings among individuals with a genetic mutation known to cause Alzheimer's.

New AAN Guidelines for the Management of Disorders of Consciousness

New AAN Guidelines for the Management of Disorders of Consciousness

The new guidelines place a substantial emphasis on the importance of introducing high-quality rehabilitation early in these patients.

Combo Physical, Mental Activity Prevents Cognitive Decline

Combo Physical, Mental Activity Prevents Cognitive Decline

Benefits seen were greater than for social interaction alone in older black population.

Sensor Array May Detect De Novo Parkinson Disease in Breath

Sensor Array May Detect De Novo Parkinson Disease in Breath

Sensitivity, specificity, accuracy values of 79, 84, and 81% for detecting PD from controls.

Cognitive Impairment Profiles Differ Between Parkinson's, Alzheimer's

Cognitive Impairment Profiles Differ Between Parkinson's, Alzheimer's

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As the neurodegenerative processes of Alzheimer disease and Parkinson disease are different, early cognitive impairment also present differently in these diseases.

New Clinical Guideline for Evaluating Alzheimer's, Related Dementias

New Clinical Guideline for Evaluating Alzheimer's, Related Dementias

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Currently, there are no US consensus on best clinical practice guidelines that incorporate multispecialty recommendations for evaluating cognitive impairment that are thought to be due to Alzheimer's disease and Related Dementias (ADRD) for use by physicians and nurse practitioners.

Visual Function Deficits Up in Developmental Dyslexia

Visual Function Deficits Up in Developmental Dyslexia

Increased prevalence of deficits in visual function vs typically developing school-age children.

Retinal Nerve Fiber Layer Thickness May Be Associated With Cognitive Function

Retinal Nerve Fiber Layer Thickness May Be Associated With Cognitive Function

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Thinning of the retinal nerve fiber layer has been linked to worsening cognitive function and may be valuable in identifying individuals who may be at risk for cognitive decline.

Menopausal Hormone Therapy Slows Cognitive Decline in Postmenopausal Women

Menopausal Hormone Therapy Slows Cognitive Decline in Postmenopausal Women

Hormone therapy in postmenopausal women with mild cognitive impairment was examined.

Metabolic Health Predicative of Cognitive Development in Children

Metabolic Health Predicative of Cognitive Development in Children

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Researchers assessed whether current metabolic parameters are inversely associated with cognitive functioning.

Dementia, Alzheimer Disease Risk Increased With Lower Branched-Chain Amino Acid Levels

Dementia, Alzheimer Disease Risk Increased With Lower Branched-Chain Amino Acid Levels

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Lower BCAA levels may be associated with an increased risk of incident dementia.

Child Neuroblastoma Survivors at Risk for Psychological Impairment

Child Neuroblastoma Survivors at Risk for Psychological Impairment

Psychological impairment seen particularly in those with chronic health conditions

Long-Term Type 1 Diabetes Associated With Cognitive Decline

Long-Term Type 1 Diabetes Associated With Cognitive Decline

Deficits similar for long-term type 1 diabetes and age-matched patients with type 2 diabetes

Visual Test Improves Prediction of Dementia in Primary Care

Visual Test Improves Prediction of Dementia in Primary Care

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Administering a visual association test in patients with a small decline on the Mini-Mental State Examination during a 2-year period has substantial incremental value for identifying those at elevated risk for developing dementia.

Cannabis Use, Cognitive Functioning Link Small in Adolescents, Young Adults

Cannabis Use, Cognitive Functioning Link Small in Adolescents, Young Adults

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Associations between cannabis use and cognitive functioning in adolescents and young adults are small.

Multiple Sclerosis Guidelines: AAN's Recommendations for Initiating, Switching, Stopping Disease-Modifying Therapy

Multiple Sclerosis Guidelines: AAN's Recommendations for Initiating, Switching, Stopping Disease-Modifying Therapy

The new guidelines focus on helping clinicians decide when to initiate, switch, or discontinue disease-modifying therapies for multiple sclerosis.

Siponimod Reduces Risk for Disability Progression in Secondary Progressive MS

Siponimod Reduces Risk for Disability Progression in Secondary Progressive MS

Investigators believe the siponimod EXPAND study is the first trial of disease-modifying therapy to show superiority over a placebo for disability progression in SPMS.

Newly Proposed Definition of Alzheimer's Disease Focuses on Biologic Criteria

Newly Proposed Definition of Alzheimer's Disease Focuses on Biologic Criteria

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The NIA-AA has proposed updates to the 2011 guidelines for symptomatic stages of Alzheimer's disease to include the idea that certain imaging and cerebrospinal fluid biomarkers are valid proxies for neuropathologic changes of AD.

Cannabinoids May Decrease Seizure Frequency in Refractory Epilepsy

Cannabinoids May Decrease Seizure Frequency in Refractory Epilepsy

A reasonable proportion of patients with epilepsy who have received treatment with pharmaceutical-grade cannabidiol products along with antiepileptic drugs have experienced a decrease in seizure frequency.

High total cholesterol linked to lower risk of cognitive decline in elderly

High total cholesterol linked to lower risk of cognitive decline in elderly

Cognitive decline risk is lowered in individuals aged 85 and older with high cholesterol.

Cerebral palsy, epilepsy risk associated with lower Apgar score

Cerebral palsy, epilepsy risk associated with lower Apgar score

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An inverse relation was observed between epilepsy and cerebral palsy and 5-minute and 10-minute Apgar scores.

Long-term memory enhanced by electrical stimulation of the amygdala

Long-term memory enhanced by electrical stimulation of the amygdala

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Modulate electrical stimulation of the amygdala may improve declarative memory without provoking any emotional reaction.

NFL players do not have significantly increased mortality risk

NFL players do not have significantly increased mortality risk

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Among NFL football players who began their careers between 1982 and 1992, career participation in the NFL, compared with limited NFL exposure obtained primarily as an NFL replacement player during a league-wide strike, was not associated with a statistically significant difference in long-term all-cause mortality.

Solanezumab does not change cognitive decline in mild Alzheimer’s disease

In patients with mild Alzheimer's disease solanezumab, an antibody designed to facilitate clearance of amyloid-beta plaques, did not significantly reduce cognitive decline over time.

Green leafy vegetable consumption linked to slower cognitive decline

Green leafy vegetable consumption linked to slower cognitive decline

Intake of primary nutrients and bioactives in green leafy vegetables is associated with slower cognitive decline.

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