Neurology

Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

Causes of death in patients with epilepsy were assessed to determine the presence of cardiac pathology.

Overuse of Neuroimaging in the Emergency Department Reported for Pediatric Headache

Overuse of Neuroimaging in the Emergency Department Reported for Pediatric Headache

Investigators examined rates, predictors, and outcomes of neuroimaging in pediatric and adolescent patients who presented to the ED with a headache.

Retinal Nerve Fiber Layer Thickness May Be Associated With Cognitive Function

Retinal Nerve Fiber Layer Thickness May Be Associated With Cognitive Function

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Thinning of the retinal nerve fiber layer has been linked to worsening cognitive function and may be valuable in identifying individuals who may be at risk for cognitive decline.

Menopause Transition Often Prompts Changes in Migraine Pattern, Characteristics

Menopause Transition Often Prompts Changes in Migraine Pattern, Characteristics

This retrospective study sought to assess migraine patterns in 69 menopausal women between ages 40 and 60 who were treated at Partners Healthcare Hospitals for concurrent migraine headache.

Weighing the Risks of Deep Brain Stimulation

Weighing the Risks of Deep Brain Stimulation

DBS has been known to generate other movement-related disorders such as dyskinesias, blepharospasm, and hypokinesia.

Menopausal Hormone Therapy Slows Cognitive Decline in Postmenopausal Women

Menopausal Hormone Therapy Slows Cognitive Decline in Postmenopausal Women

Hormone therapy in postmenopausal women with mild cognitive impairment was examined.

First Marijuana-Based Drug Approved to Treat LGS, Dravet Syndrome

First Marijuana-Based Drug Approved to Treat LGS, Dravet Syndrome

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This marks the first approved drug that contains an active ingredient derived from marijuana as well as the first treatment approved for patients with Dravet syndrome.

NEURO Study: Neonatal neuroimaging with strong negative predictive value for developmental outcomes

In multivariate analyses, adverse late cranial ultrasound findings were an independent risk factor for full scale IQ scores 70.

Prenatal antidepressant exposure may increase risk of poor motor development

A meta-analysis of 18 studies examining the association of prenatal antidepressant exposure with motor development in children showed a small overall effect of worse motor development outcomes among children exposed to antidepressants in pregnancy.

Hearing Loss Linked to CVD Risks in Elderly

Hearing Loss Linked to CVD Risks in Elderly

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Elderly patients aged 80 years and older have an increased risk of developing cardiovascular disease (CVD) with worse hearing as well as hearing deterioration.

Higher Blood Pressure at Mid-Life Increases Dementia Risk

Higher Blood Pressure at Mid-Life Increases Dementia Risk

Findings for those with systolic BP 130 mm Hg at age 50 years

Genetic Risk Score Better Than APOE Alone for Assessing Risk for Alzheimer's Dementia

Genetic Risk Score Better Than APOE Alone for Assessing Risk for Alzheimer's Dementia

The genetic risk score primarily modified the risk for and onset of dementia and AD among homozygous carriers for APOE ε4.

Dementia, Alzheimer Disease Risk Increased With Lower Branched-Chain Amino Acid Levels

Dementia, Alzheimer Disease Risk Increased With Lower Branched-Chain Amino Acid Levels

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Lower BCAA levels may be associated with an increased risk of incident dementia.

Child Neuroblastoma Survivors at Risk for Psychological Impairment

Child Neuroblastoma Survivors at Risk for Psychological Impairment

Psychological impairment seen particularly in those with chronic health conditions

Excessive Daytime Sleepiness Linked to Elevated β-Amyloid Accumulation in Elderly Persons

Excessive Daytime Sleepiness Linked to Elevated β-Amyloid Accumulation in Elderly Persons

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Elderly individuals without dementia who have elevated daytime sleepiness may be at greater risk for β-amyloid accumulation.

Trials for Investigational Alzheimer's Treatment Lanabecestat Discontinued

Trials for Investigational Alzheimer's Treatment Lanabecestat Discontinued

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The independent data monitoring committee (IDMC) concluded that the 2 trials (AMARANTH and DAYBREAK-ALZ) investigating the treatment in mild Alzheimer's disease dementia, were not likely to meet their primary endpoints of change from baseline on the 13-item Alzheimer's Disease Assessment Scale - Cognitive Subscale.

Long-Term Type 1 Diabetes Associated With Cognitive Decline

Long-Term Type 1 Diabetes Associated With Cognitive Decline

Deficits similar for long-term type 1 diabetes and age-matched patients with type 2 diabetes

Accumulation of Brain Pathologies Linked to Reduced Activity in Older Adults

Accumulation of Brain Pathologies Linked to Reduced Activity in Older Adults

Brain autopsies of participants of the Rush Memory Aging project (n=428) were studied to identify the association between brain pathologies and total daily physical activity and mortality.

CDC: Outpatient Rehab Rates Suboptimal for Stroke Survivors

CDC: Outpatient Rehab Rates Suboptimal for Stroke Survivors

Based on data from four states, in 2015, 35.5% of adult stroke survivors used outpatient rehab.

Diethylstilbestrol Use in Pregnancy Linked to Multigenerational Neurodevelopmental Deficits

Diethylstilbestrol Use in Pregnancy Linked to Multigenerational Neurodevelopmental Deficits

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Diethylstilbestrol exposure during pregnancy is associated with multigenerational neurodevelopmental deficits in childhood, including ADHD.

Patients with Frontal Chronic Headaches May Benefit from Endoscopic Decompression Surgery

Patients with Frontal Chronic Headaches May Benefit from Endoscopic Decompression Surgery

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Oral medication, botulinum toxin type A injections, and endoscopic decompression surgery were all compared in the treatment of patients with frontal secondary headaches due to STN and SON configuration.

Visual Test Improves Prediction of Dementia in Primary Care

Visual Test Improves Prediction of Dementia in Primary Care

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Administering a visual association test in patients with a small decline on the Mini-Mental State Examination during a 2-year period has substantial incremental value for identifying those at elevated risk for developing dementia.

FDA Expands Use of MS Drug to Include Children

FDA Expands Use of MS Drug to Include Children

Gilenya is the first multiple sclerosis drug approved for children

Resistance Exercise May Reduce Depressive Symptoms in Adults

Resistance Exercise May Reduce Depressive Symptoms in Adults

Meta-analysis shows reduction in depressive symptoms with RET, with considerable heterogeneity

Amyotrophic Lateral Sclerosis: Update for the Primary Care Clinician

Amyotrophic Lateral Sclerosis: Update for the Primary Care Clinician

Patients with ALS require multidisciplinary care and rehabilitative interventions; maximizing independent function and quality of life are the goals.

Some Anticholinergic Drugs May Be Linked to Dementia

Some Anticholinergic Drugs May Be Linked to Dementia

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Anticholinergic drugs for depression, urologic conditions, or Parkinson disease are associated with potential dementia occurrences up to 20 years after drug exposure.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Review of 4 studies shows positive link for clinically significant anxiety in midlife, future dementia

Will a New Cooling Device Benefit Patients With Insomnia?

Will a New Cooling Device Benefit Patients With Insomnia?

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Therapeutics to cool the brain may someday be a safer alternative to hypnotics.

Cannabis Use, Cognitive Functioning Link Small in Adolescents, Young Adults

Cannabis Use, Cognitive Functioning Link Small in Adolescents, Young Adults

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Associations between cannabis use and cognitive functioning in adolescents and young adults are small.

Hans Asperger, Leading Autism Researcher, Tied to Nazi Child Euthanasia Program

Hans Asperger, Leading Autism Researcher, Tied to Nazi Child Euthanasia Program

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Medical records of 48 children examined by Asperger show that he specifically called for 12 of the children to be transferred to the Am Spiegelgrund facility, the 'euthanasia' institution founded in 1940.

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