More primary care practices have been making medical records, including clinical notes, available to patients via secure electronic portals.
Talzenna, a poly (ADP-ribose) polymerase (PARP) inhibitor, was evaluated in EMBRACA, an open-label trial that randomized patients with gBRCAm HER2-negative locally advanced or metastatic breast cancer (N=431) to receive talazoparib 1mg or physician's choice of chemotherapy (capecitabine, eribulin, gemcitabine, or vinorelbine).
The expanded approval was supposed by safety and efficacy data from the Phase 3 ACCESS IUS trial (N=1751) in women receiving Liletta. In the trial, Liletta demonstrated >99% efficacy in preventing pregnancy for up to 5 years in a broad patient population.
The job market for new nephrologists is continuing to improve, and most fellows would recommend nephrology to medical students or residents.
Of TTS survivors, 11.9% readmitted within 30 days, with associated mortality of 3.5%.
Similar weight, liver enzyme improvements seen with group- and web-based programs for NAFLD patients.
Postmenopausal women with weight loss have a reduced risk for breast cancer.
The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.
The effect of high-intensity interval training with a bout of moderate-intensity continuous training on glucose levels was examined in T1D.
Decline in episodic memory scores seen with older age slower after vs before cataract surgery.
Higher postoperative pain score, worse quality of life for post-op pain management with opioids.
Larger cities with higher base transmission potentials have more diffuse influenza epidemics.
Assay can be used to determine blood donor and patient non-ABO red blood cell types.
Investigators examine the effect of a low-fat, plant-based diet on insulin resistance and body composition.
The use of β-blockers in the first trimester of pregnancy may not greatly increase the risk for major congenital malformations in offspring.
A 7-item pain intensity measure for persons with dementia has shown initial validity and reliability.
The burden of childhood and infant pneumonia can be effectively reduced through the use of the pneumococcal Haemophilus influenzae protein D conjugate vaccine.
The consumption of dietary gluten was not associated with microscopic colitis risk in patients without celiac disease.
But drinking 1.5 drinks/day linked to increased mortality after adjustment for multiple confounders.
No benefit regarding quality of life or thyroid-related symptoms found for thyroid hormone therapy.
Findings among individuals with a genetic mutation known to cause Alzheimer's.
Five possible cases reported in Washington state; 14 confirmed cases reported in Colorado.
One in 77 US children reportedly had heart conditions in 2016, with special needs in 60%.
Higher Levels of Anti-CA15.3 and Anti-CA125 Linked to Increased Risk for Mucinous Epithelial Ovarian Cancer
Researchers used the EPIC Cohort to identify whether anti-CA125 and anti-CA15.3 antibodies alone or in combination with antigens may determine epithelial ovarian cancer risk.
Higher risk for problems seen among black women, women with other health conditions.
Among cancer survivors, illness perception may affect patient health-related quality of life and mortality.
Although ovarian cancer risk may be reduced with regular use of low-dose aspirin, the use of nonaspirin analgesics may increase the risk of ovarian cancer among long-term, high-quantity users.
AAPA and NCCPA partner in a national advertising campaign to raise awareness of the PA profession.
Researchers analyze the dietary habits of 260 patients in the early stages of multiple sclerosis from baseline to 5 years after initial onset of symptoms.
For this analysis, the authors used follow-up data from all 7020 patients included in the EMPA-REG OUTCOME trial to estimate the effect of empagliflozin on all-cause mortality vs placebo over the duration of a patient's lifetime.
The study authors searched MEDLINE from inception through July 2018 to obtain relevant cohort studies and randomized trials assessing HBVr incidence secondary to pharmaceutical agents.
Common carotid artery wall thickness measured using magnetic resonance imaging is more consistently associated with incident cardiovascular disease outcomes than intima-media thickness measured by ultrasound.
A $69 billion merger between health insurer Aetna and pharmacy manager CVS Health has been approved, according to the US.Justice Department.
Diet explains little of the variation in serum urate levels in the general population, while genetic factors make a greater contribution.
Overall, 36.6% of US adults consumed fast food on a given day during 2013 to 2016.
Study authors at the American College of Gastroenterology (ACG) Scientific Meeting 2018 presented late-breaking data from the induction phase of the Phase 3 UNIFI study.
The quality of patient monitoring may improve if the clinical practice guidelines are improved, as many healthcare professionals use the guidelines in their monitoring of patients taking lithium.
The Get With the Guidelines-Stroke program includes measures such as neurologist assessment, rehabilitation evaluation, and education on stroke risk factors.
Rate of spontaneous vaginal delivery similar for immediate pushing or waiting for 60 minutes.
Greater weight gain in early childhood often carries over to overweight and obesity in adolescence.
An outbreak of flea-borne typhus in Los Angeles County has so far resulted in 57 cases, including 20 in Pasadena and 9 in downtown Los Angeles.
Recommendations for the management of type 2 diabetes have been updated, according to a consensus report by the American Diabetes Association and the European Association for the Study of Diabetes.
The test works by measuring levels of anti-cytolethal distending toxin B (CdtB) and anti-vinculin, 2 biomarkers of post-infectious IBS-D and IBS-M.
Safety data for Fycompa was consistent with the safety profile in adult populations without the need for weight-based dosing.
The new guidelines place a substantial emphasis on the importance of introducing high-quality rehabilitation early in these patients.
The approval of the expanded age range was based on data from a clinical trial which evaluated the efficacy of Gardasil (quadrivalent human papillomavirus recombinant vaccine) in 3253 women 27-45 years of age with a median duration of follow-up of 3.5 years post-dose 3.
Bose Hearing Aid is user-fitted device for people 18 and older with mild-to-moderate hearing loss.
For children, infants with febrile seizure, recurrence down with acetaminophen vs no antipyretic.
Implementing ACC/AHA guideline would direct antihypertensive meds to adults at high CVD risk.
One of the goals of the US Department of Health and Human Services National Viral Hepatitis Action Plan is to eliminate mother-to-infant transmission of HCV infection.
The petition was submitted by a number of non-profit organizations including the Center for Science in the Public Interest and the Breast Cancer Fund.
Comprehensive bipartisan package earmarks billions of dollars to fight opioid abuse in the United States.
Children with congenital heart disease presenting to ED at increased risk for morbidity, mortality.
14 million need to receive two doses of vaccine to reach goal of 80% vaccination by 2026.
Benefits include better functional health, sleep-related quality of life, psychological well-being.
Investigators examined treatment response of sofosbuvir-based DAA in patients with chronic hepatitis C with compensated liver cirrhosis in a community care setting.
The Company states that the NDA is supported by robust clinical trial data, including patients studies where more than 1600 seizures were treated with Valtoco nasal spray.
Wide variations in influenza vaccine coverage have been noted across healthcare personnel based on occupation and worksite.
Lixisenatide reduces progression of urinary albumin-creatinine ratio in patients with macroalbuminuria.
Twenty-four percent of adults aged 65 years who undergo intubation in ED are discharged home.
The odds of language delay were lower at 18 months and 36 months in children exposed to AEDs in utero whose mothers took folic acid.
The risk for late-onset epilepsy was lower in patients with higher physical activity levels and moderate alcohol intake.
Recurrence of seizures was reported in 28.2% of patients who attempted withdrawal.
Weight loss may indicate a cancer diagnosis in patients presenting in primary care, specifically when weight loss correlates to another cancer-related clinical feature.
Day-and-night hybrid closed-loop insulin delivery improves glucose control compared with sensor-augmented pump therapy.
Analysis of 2 phase 3 clinical trials evaluating the safety/efficacy of glecaprevir/pibrentasvir in people with HCV coinfected with HIV-1 found an overall sustained virologic response of 98% at week 12 of treatment in those with or without cirrhosis.
Probands of African or Hispanic/Latino descent with early-onset atrial fibrillation are more likely than European Americans to have a first-degree relative with AF.
More than three-quarters of physicians believe that violence in the ED has harmed patient care.
Adults with high vs low MeDi score have lower risk for advanced age-related macular degeneration.
82 percent of variant carriers identified in exome sequencing had not undergone prior testing.
Documentation of advance directives more common in Northeast, among small adult day services centers.
Approximately 28% of stroke patients have diabetes, and the presence of diabetes can increase the risk for poor stroke outcome.
Active Choice Intervention Effective in Increasing Influenza Vaccination Rates at Primary Care Practices
Influenza vaccination rates decline as the clinic day progresses.
Screening of adult patients with significant depressive symptoms is often inadequate in the primary care setting, especially among those with hazardous alcohol consumption.
New data suggest an association between general practitioners' prescribing habits for urinary tract infections and UTI-related E coli bacteremia incidence.
Short sleep duration linked to reduced risk for black men; risk up for white men with long sleep duration.
For patients with CAP, antibiotic regimens including a fluoroquinolone may reduce mortality risk by 1-2% compared to beta-lactams and cephalosporins alone.
In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection
A combination single tablet once-a-day regimen of doravirine/lamivudine/tenofovir disoproxil fumarate demonstrated non-inferiority and no significant adverse events when compared with continuation of established antiretroviral therapy in adults infected with HIV-1.
Women with ovarian or endometrial cancer who adhere to a ketogenic diet may benefit from a selective loss of fat mass and a reduction in fasting serum insulin, while still retaining lean mass.
Changes in allergy records were suggested by the allergy service consult for 62% of the patients.
Both doses will be supplied in single-dose, prefilled syringes for manual injection.
For women at high risk for cystitis recurrence who drink low volumes of fluid daily, increasing water intake prevents recurrence.
For both men and women, Southern dietary pattern is largest mediating factor for difference in hypertension.
Despite dietary recommendations, soft drinks make up about one-fifth of total beverage consumption by US youth.
A documented β -lactam allergy was found in more than one-third of patients receiving broad-spectrum antibiotics, however, only 10% of patients were found to be truly allergic.
The use of a moderate to low susceptibility antibiotic to treat a urinary tract infection [UTI] may result in a 1.74-fold increase in the odds of an emergency department readmission within 30 days for another UTI.
Breastfeeding is inversely associated with body mass index z scores measured at 12 months, and the association is attenuated with formula supplementation by 6 months.
Monovalent Acellular Pertussis Vaccine Safe and Effective for Neonates With Mothers Unvaccinated for Tdap
The monovalent acellular pertussis vaccine may be beneficial to neonates whose mothers did not receive Tdap vaccine during pregnancy.
Hypertensive disorders of pregnancy and gestational diabetes may increase the risk for hot flashes during menopause.
Women who were exposed to sexual harassment and/or assault were found to experience higher blood pressure, poorer sleep, and mood changed that can affect mental health.
Patients undergoing robotic hysterectomy were found to report comparable pain scores when receiving celecoxib perioperatively or ketorolac postoperatively.
A case and commentary published in the AMA Journal of Ethics discusses the ethics of primary care physician response to direct-to-consumer genetic testing results of concerned patients.
Almost 43% of those presenting to NCI center for second opinion have change in diagnosis.
Most studies evaluated fish oil, acupuncture, indigo naturalis, curcumin, meditation.
Use of ondansetron for the treatment of nausea and vomiting in pregnancy does not appear to be associated with birth defects.
The first human case of a strain of hepatitis E previously found only in rats was diagnosed in a Hong Kong man who received a liver transplant in May 2017.
Light treatments successfully corrected abnormal timing of melatonin circadian rhythms in perimenopausal women with depression and improved mood and sleep within 2 weeks.
For certain patients with endocarditis on the left side of the heart under stable condition, switching from intravenous (IV) antibiotics to orally administered antibiotics is noninferior to staying on IV treatment.
The recent Supreme Court decision on crisis pregnancy centers is expected to complicate the future of some health laws.