Prevention of prostate cancer
The 5-ARI agents reduce the level of dihydrotestosterone, a hormone that can contribute to the growth of prostate cancer. ASCO and AUA suggest that men without any signs of prostate cancer who have a prostate-specific antigen (PSA) level <3.0 and are screened regularly or plan to get yearly PSA tests speak to their clinician about the preventive therapy. Men who are already taking a 5-ARI for other conditions should consider continuing the treatment as a means of preventing the development of prostate cancer.
ASCO and AUA based their recommendations in part on results from the Prostate Cancer Prevention Trial, in which participants took a 5-ARI for one to seven years. Most of the men who took the drug to prevent the disease showed an overall relative risk reduction of approximately 25%.
The guideline was published online ahead of print in the Journal of Clinical Oncology (accessed April 17, 2009) and The Journal of Urology.