Ob/Gyn Information Center News Archive

β-Blockers in Early Pregnancy Not Linked to Significant Risk for Overall, Cardiac Malformations

The use of β-blockers in the first trimester of pregnancy may not greatly increase the risk for major congenital malformations in offspring.

Minority Women at Higher Risk for Severe Maternal Morbidity

Higher risk for problems seen among black women, women with other health conditions.

Timing of Pushing Does Not Impact Spontaneous Vaginal Delivery

Rate of spontaneous vaginal delivery similar for immediate pushing or waiting for 60 minutes.

Need for Adequate Screening for Infants With HCV Infected Mothers During Pregnancy

One of the goals of the US Department of Health and Human Services National Viral Hepatitis Action Plan is to eliminate mother-to-infant transmission of HCV infection.

Genomic Screening Can ID Undetected BRCA1/2 Cancer Risk

82 percent of variant carriers identified in exome sequencing had not undergone prior testing.

Monovalent Acellular Pertussis Vaccine Safe and Effective for Neonates With Mothers Unvaccinated for Tdap

The monovalent acellular pertussis vaccine may be beneficial to neonates whose mothers did not receive Tdap vaccine during pregnancy.

Disorders in Pregnancy May Increase Risk for Hot Flashes During Menopause

Hypertensive disorders of pregnancy and gestational diabetes may increase the risk for hot flashes during menopause.

Celecoxib Offers Pain Relief Comparable to Ketorolac After Robotic Hysterectomy

Patients undergoing robotic hysterectomy were found to report comparable pain scores when receiving celecoxib perioperatively or ketorolac postoperatively.

Second Opinion at NCI Center Valuable for Breast CA Patients

Almost 43% of those presenting to NCI center for second opinion have change in diagnosis.

Ondansetron in Pregnancy Not Linked to Most Birth Defects

Use of ondansetron for the treatment of nausea and vomiting in pregnancy does not appear to be associated with birth defects.

Light Therapy Offers Nonpharmacologic Treatment for Perimenopausal Depression

Light treatments successfully corrected abnormal timing of melatonin circadian rhythms in perimenopausal women with depression and improved mood and sleep within 2 weeks.

Uncertain Future for Health Laws After Supreme Court Crisis Pregnancy Center Ruling

The recent Supreme Court decision on crisis pregnancy centers is expected to complicate the future of some health laws.

Talazoparib Shows Antitumor Activity in Advanced Breast Cancer, Germline BRCA Mutation

Talazoparib, a poly(adenosine diphosphate-ribose) inhibitor, may significantly enhance progression-free survival in patients with advanced breast cancer and a germline BRCA1/2 mutation.

Gestational Diabetes Associated With Increased Risk for Postpartum Depression

These findings suggest an increased risk for postpartum depressive symptoms in mothers with gestational diabetes, independent of depressive symptomatology during pregnancy.

Newer Hormonal Contraception May Cut Ovarian Cancer Risk

Combined hormonal contraception use tied to lower risk; risk down with increasing duration of use.

The Ethics of Forced Cesareans: An Unthinkable Practice, Examined

"Moral norms" in the medical domain must be applied to pregnant women and their physicians.

Cesarean Delivery, Early Childhood Antibiotic Use Not Associated With Risk for ADHD

This research rejects any association between increased risk for ADHD and changes in children's microbiota related to cesarean delivery or antibiotic use.

Ribociclib FDA-Approved For Additional Indications in HR+, HER2- Advanced Breast Cancer

The FDA based its approval on the results of a triplet of phase 3 studies, the MONALEESA-2, MONALEESA-3, and MONALEESA-7.

AAP Report Addresses Managing Fetal Alcohol Spectrum Disorder

Recommendations developed to support pediatric providers in managing patients with FASD diagnosis.

Tucatinib May Be A Safe, Novel Treatment for ERBB2/HER2-Positive Breast Cancer

For this phase 1b study, researchers enrolled 57 patients with ERBB2/HER2-positive metastatic breast cancer previously treated with trastuzumab and a taxane.

Knowledge, Confidence Barriers Hinder Effective Management of Vulvovaginal Atrophy

Researchers created a 3-part online survey to assess the knowledge, attitudes, and barriers of primary care providers and gynecologists regarding vulvovaginal atrophy.

Selective Serotonin Reuptake Inhibitors May Increase Risk for Suboptimal Fetal Growth

Use of serotonin reuptake inhibitors for maternal depression may increase the risk for low birth weight in children.

Effect of Folic Acid Supplementation on Pre-Eclampsia Prevention in High-Risk Patients

High-dose folic acid supplementation beyond the first trimester does not prevent pre-eclampsia in high-risk women.

Lifestyle Interventions Cut Excess Gestational Weight Gain

Findings among diverse population of overweight, obese women.

Including Hypertensive Disorders of Pregnancy in CVD Risk Score Does Not Improve CVD Risk Prediction

Adding history of hypertensive disorders of pregnancy to the current cardiovascular disease (CVD) risk score does not improve CVD prediction in low-risk women.

Physical Activity as a Lifestyle Factor Influencing Early Menopause

Researchers concluded that physical activity was not associated with risk for early menopause.

Gestational Diabetes Tied to Subsequent Glucose Disorders

Long-term effects seen in mothers, but offspring not significantly overweight, obese.

NAMS: Breast Cancer Diagnosis May Indicate Lower Vitamin D Levels, Obesity in Postmenopausal Women

The North American Menopause Society has found that postmenopausal women with a breast cancer diagnosis may have vitamin D deficiency as well as higher rates of obesity.

Beyond BRCA: New Predisposition Genes Linked to Breast, Ovarian Cancers

Whole-exome sequencing revealed that PALB2, ATM, CHEK2, and MSH6 genes were significantly associated with an increased risk of breast cancer; MSH6, RAD51C, TP53, and ATM were found to be linked to an increased risk of ovarian cancer.

Imvexxy Now Available in 4mcg Dosage Strength for Dyspareunia Due to Menopause

According to the Imvexxy prescribing information, women should generally be started at the 4mcg dosage strength with dosage adjustment guided by clinical response.

Depression or Psychosis Predicts Perinatal Recurrence of Bipolar Disorder

Investigators sought to determine clinical predictors to identify risk for perinatal recurrence in women with bipolar disorder.

Adverse Effects of Marijuana Use in Pregnancy: Current Research Is Questionable at Best

Many women are unconvinced of the potential harmful effects of marijuana use in pregnancy due to the lack of available evidence.

Prenatal Tdap Vaccination Not Associated With an Increased Risk of Autism

No association was observed between prenatal vaccination of Tdap vaccination and an increased risk of autism spectrum disorder risk in children.

Perinatal Photoperiod May Influence Lifetime Depression in Offspring

Extreme differences in daily photoperiod during pregnancy may be related to risk for lifetime depression in offspring.

Adding Fish Oil in Pregnancy May Lead to Higher Child BMI

Supplementation linked to higher BMI z score at age 6 years but no higher proportion of obese children.

Recent Increase in Contraception Use Noted Among US Teenagers

Increases in use of 1 or more contraceptive methods, dual-method use, long-acting reversibles.

Labor Induction Linked to Hypertensive Complication Prevention in Women With Chronic Hypertension

For expectant mothers with chronic hypertension, labor induction after 38 weeks of gestation may prevent hypertensive complications without increasing the risk of cesarean delivery.

Guidelines for Managing Perimenopausal Depression Now Available

The 5 topics addressed by the 11-member expert panel include epidemiology, clinical presentation, therapeutic effects of antidepressants, effects of hormone therapy, and the effectiveness of other therapies (eg, psychotherapy, exercise, natural health products).

Cell-Free DNA vs Invasive Fetal Karyotyping for High-Risk Pregnancies

For women with pregnancies at high risk for trisomy 21, performing cell-free DNA tests over direct invasive karyotyping procedures did not reduce the risk for miscarriage.

USPSTF Reaffirms Screening for Syphilis in Pregnancy

Screening results in decrease in incidence of congenital syphilis; no harms identified for penicillin.

Dexamethasone Improves Outcomes for Patients Undergoing In Vitro Fertilization

Investigators assessed whether adrenal suppression with low-dose dexamethasone improved IVF outcomes.

Vitamin D Deficiency Associated With Lower Success Rates of Fertility Treatment in PCOS

Investigators sought to determine the effect of vitamin D deficiency on the success of ovarian stimulation in women with PCOS or unexplained infertility.

CDC: Most Babies Born in 2015 Started Out Breastfeeding

But less than one-half and one-quarter are exclusively breastfeeding through 3 and 6 months.

Examining the Ethics of Deceased vs Living Uterus Donors

The first live birth after a uterus transplant was achieved in Sweden in 2014, followed by 4 more births, all from uteri provided by living donors.

Skin Microbiota Differ for Obese, Non-Obese Undergoing C-Section

Obese women have significantly higher bacterial biomass of lower diversity at the incision site.

Reproductive Management in Multiple Sclerosis: Quick Takeaways for Your Practice

While it is now well-established that having MS should not limit patients' reproductive choices, this was not always the case.

Breastfeeding Linked to Lower Risk of Stroke Post-Menopause

Stroke risk 19% lower with breastfeeding for 1 to 6 months; stronger link for longer duration.

FDA Rejects Treatment for Uterine Fibroids Based on Safety Concerns

The NDA included data from two Phase 3 clinical trials (VENUS I and VENUS II), all four Phase 3 European Union registration studies, and real-world data of >700,000 women with uterine fibroids across 80 countries.

Labor Induction Reduces Cesarean Delivery Frequency for Low-Risk Women

Cesarean delivery frequency may be significantly reduced with induction of labor at 39 weeks in low-risk nulliparous expectant mothers.

WPSI Recommends Annual Urinary Incontinence Screening

Due to limited evidence, other experts urge caution in implementing guideline for women.

Genitourinary Syndrome of Menopause: A Consensus Statement From the ISSWSH

The International Society for the Study of Women's Sexual Health convened an expert consensus panel to discuss the use of androgens in the management of genitourinary syndrome of menopause.

Lumpectomy + Radiation May Cut Breast Cancer Mortality in DCIS

Lumpectomy, radiotherapy tied to reduction in breast cancer mortality vs lumpectomy, mastectomy.

In Shocking Opposition, Trump Administration Denies Decades of Breastfeeding Research

In a move that shocked world health officials, the Trump administration indicated its opposition to a resolution intended to encourage breastfeeding among new mothers

Characteristics of Menstrual Cycle Associated With Early Natural Menopause

Investigators examined the relationship between menstrual cycle characteristics in adolescence and early adulthood and the risk for early natural menopause.

Sufficient Preconception Vitamin D Tied to Lower Miscarriage Risk

However, increased vitamin D levels in early pregnancy not correlated with reduced pregnancy loss.

No Impact on Carotid Artery Intima-Media Thickness Following Cessation of Menopausal Hormone Therapy

A follow-up study from KEEPS found that cessation of menopausal hormone therapy did not change the expected trajectory of carotid artery intima-media thickness over a 3-year period.

Neurodevelopmental Anomalies, Birth Defects Linked to Zika Identified

Many children born to mothers with Zika infection do not undergo all recommended assessments.

FDA: Improper Use of Rupture of Membranes Tests Linked to Fetal Deaths

ROM tests are used to aid in diagnosing ruptured membranes in pregnant women through analysis of vaginal secretions.

Vitamin D Supplementation Does Not Improve Fetal, Infant Growth

Findings based on study of Bangladeshi women and infants, a population with known deficiency.

Thyroid Dysfunction Linked to Gestational Diabetes

fT3 and fT3-to-fT4 ratio correlated positively with gestational diabetes at the first and second trimester.

Ectopic Lipid Deposition and Insulin Resistance Higher in Postmenopausal Women

The insulin sensitivity in post- and premenopausal women along with lipid deposition in the liver and skeletal muscle was examined.

International PCOS Network Issues New Guidelines for Management and Diagnosis of PCOS

International evidence-based guidelines include 166 recommendations and practice points to improve health outcomes of women with PCOS.

'Good' Cholesterol May Not Be So in Postmenopausal Women

High total HDL cholesterol in postmenopausal women may mask heart disease risk.

Effect of Esomeprazole on Prolonging Gestation in Preterm Preeclampsia

As there is currently no treatment option available to slow the progression of preeclampsia, clinicians assess esomeprazole, a proton pump inhibitor, as a therapeutic candidate for this challenging condition.

TGFB1 Mutation Ups Radiation-Induced Breast Fibrosis Risk

C-509T allele and postoperative cosmetic surgery significantly linked to breast fibrosis risk.

Heat-Stable Carbetocin Safe Alternative to Oxytocin for Postpartum Hemorrhage Prevention

Heat-stable carbetocin — an analog of oxytocin — was found to be noninferior to oxytocin in preventing hemorrhage associated with vaginal birth and may be beneficial in low- and middle-income countries.

FDA Warns of the Dangers of 'Vaginal Rejuvenation'

Numerous cases of vaginal burns or scarring have been linked to the procedures.

Higher Risk of In Situ Breast CA, Ovarian Tumors With Fertility Treatment

No increased risk of corpus uteri, invasive breast cancer for women undergoing assisted reproduction.

2002 to 2014 Saw Hike in AMI Rate in Pregnancy, Puerperium

Rate of acute myocardial infarction one per 12,400 for those hospitalized during pregnancy, puerperium.

Postpartum Pain Management Recommendations From the American College of Obstetricians and Gynecologists

A committee from the American College of Obstetricians and Gynecologists formulated several recommendations for safely managing pain and fatigue in women during the early postpartum period.

Inactivated Influenza Vaccine Preferred for Nursing Mothers

Women receiving the inactivated influenza vaccine demonstrated superior antibody response compared with those receiving the live attenuated influenza vaccine.

FDA Grants First Approval for CA Drug Under New Pilot Programs

Ribociclib approved in combo with AI as endocrine tx for HR-positive, HER2-negative advanced breast CA.

HPV Vaccine Failure Rates May Be Higher in Women, Girls With HIV

Vaccinated women and girls living with HIV may be at greater risk for HPV vaccine failure compared with women and girls without HIV.

Lithium Use During Pregnancy Linked to Infant, Maternal Health Risks

Maternal lithium use in the first trimester of pregnancy may increase the risk for infant malformations.

Increased Maternal Mortality Risk Associated With Recurrent Preeclampsia

Recurrent hypertensive disease of pregnancy is associated with increased risk for early all-cause and some cause-specific mortality.

New Poll Offers Women's Perspective on Women's Health Issues

The Kaiser Family Foundation recently released results from a new poll examining the public's view on women's issues.

Congenital Anomalies Not Linked to Metformin Use After First Trimester

Metformin use during the first trimester of pregnancy is not correlated with an increased risk of congenital anomalies.

Prenatal Depression More Common in Young Moms Today

Depressed mood more common in young pregnant women today than in their mothers' generation.

Preeclampsia With Severe Features Increases Risk for Cardiac Abnormalities

Women with preeclampsia with severe features had increased right ventricular systolic pressure and decreased global right ventricular longitudinal systolic strain.

Decrease in Mean Platelet Counts Seen During Pregnancy

Platelet counts of 150,000/mm at time of delivery more common with pregnancy-related complications

Menopause Transition Often Prompts Changes in Migraine Pattern, Characteristics

This retrospective study sought to assess migraine patterns in 69 menopausal women between ages 40 and 60 who were treated at Partners Healthcare Hospitals for concurrent migraine headache.

Reproductive Dysfunction Risk in Women Taking Long-Term Opioids for Musculoskeletal Pain

Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.

Vitamin D and Gestational Hypertension, Preeclampsia Risk: Is There a Connection?

Researchers from the University of Bristol found no association between 25-hydroxyvitamin D level and pregnancy-related hypertensive disorders.

Follow-up Lacking for Women With Severe Maternal Morbidity

In New Zealand, large proportion did not receive event debrief, referral to social support or specialist

Menopausal Hormone Therapy Slows Cognitive Decline in Postmenopausal Women

Hormone therapy in postmenopausal women with mild cognitive impairment was examined.

Prenatal Pediatric Visit Recommended for Expectant Families

Visit provides unique opportunity to address relationship between family and pediatric practice.

Assessing a Comprehensive Long-Acting Reversible Contraceptive Program

An evaluation assessed the nonhealthcare-related influences that have led to misconceptions about long-acting reversible contraceptives.

Ribociclib Prolongs Progression-Free Survival in Premenopausal Breast Cancer

Investigators report results from the MONALEESA-7 trial, which assessed ribociclib plus endocrine therapy in premenopausal women with advanced breast cancer.

Early Preterm Birth Linked to Increased ADHD Symptoms

Association holds after adjustment for unmeasured genetic, environmental factors

Sex Hormone Levels May Affect Postmenopausal Heart Disease Risk

Researchers assessed the effect of testosterone, estradiol, dehydroepiandrosterone, and sex hormone-binding globulin levels on coronary heart disease, heart failure, and cardiovascular disease in postmenopausal women.

Exposure to Maternal HTN May Up Risk of ASD, ADHD in Child

Hypertensive disorders of pregnancy linked to risk of poorer neurodevelopmental outcomes in offspring

No Additional Benefits With Vaginal Estradiol Tablets, Moisturizers for Postmenopausal Vulvovaginal Symptoms

Prescribed vaginal estradiol tablets and over-the-counter vaginal moisturizers may not be more effective than placebos for postmenopausal vulvovaginal symptoms.

Nutraceuticals Containing Equol May Be Effective for Postmenopausal Symptoms

Equol-containing nutraceuticals may be beneficial for postmenopausal women with vaginal symptoms.

Many Breast Cancer Survivors Do Not Undergo Annual Surveillance

In year 1, 13% did not undergo MRI or mammography; up to 19% by year 5.

Imvexxy Approved for Moderate to Severe Dyspareunia Due to Menopause

The FDA approval was supported by findings from a Phase 3, randomized, double-blind, placebo-controlled study that evaluated Imvexxy (4mcg and 10mcg) vs placebo from baseline to week 12.

Hepatitis C-Exposed Infants Not Adequately Screened

Low screening rate seen at same time as increase in hepatitis C virus prevalence among pregnant women

Oral Contraceptive Taytulla Recalled Due to Packaging Error

A physician report indicates that 4 placebo (non-hormonal) capsules were placed in the first 4 days of therapy instead of active capsules.

Consensus Statement: Managing Bipolar Disorder During and After Pregnancy

Investigators summarize data regarding the management of bipolar disorder during pregnancy and in the postpartum period.

Major Depression in Males May Lower Chances of Conception

Active major depression in women not associated with negative fertility outcomes.

Effects of the Two Types of Anorexia Nervosa on Bone Metabolism

Investigators sought to determine whether both restrictive and purging types of anorexia nervosa effect bone metabolism.

Sign Up for Free e-newsletters