Ob/Gyn Information Center News Archive

No Impact on Carotid Artery Intima-Media Thickness Following Cessation of Menopausal Hormone Therapy

A follow-up study from KEEPS found that cessation of menopausal hormone therapy did not change the expected trajectory of carotid artery intima-media thickness over a 3-year period.

Neurodevelopmental Anomalies, Birth Defects Linked to Zika Identified

Many children born to mothers with Zika infection do not undergo all recommended assessments.

FDA: Improper Use of Rupture of Membranes Tests Linked to Fetal Deaths

ROM tests are used to aid in diagnosing ruptured membranes in pregnant women through analysis of vaginal secretions.

Vitamin D Supplementation Does Not Improve Fetal, Infant Growth

Findings based on study of Bangladeshi women and infants, a population with known deficiency.

Thyroid Dysfunction Linked to Gestational Diabetes

fT3 and fT3-to-fT4 ratio correlated positively with gestational diabetes at the first and second trimester.

Ectopic Lipid Deposition and Insulin Resistance Higher in Postmenopausal Women

The insulin sensitivity in post- and premenopausal women along with lipid deposition in the liver and skeletal muscle was examined.

International PCOS Network Issues New Guidelines for Management and Diagnosis of PCOS

International evidence-based guidelines include 166 recommendations and practice points to improve health outcomes of women with PCOS.

'Good' Cholesterol May Not Be So in Postmenopausal Women

High total HDL cholesterol in postmenopausal women may mask heart disease risk.

Effect of Esomeprazole on Prolonging Gestation in Preterm Preeclampsia

As there is currently no treatment option available to slow the progression of preeclampsia, clinicians assess esomeprazole, a proton pump inhibitor, as a therapeutic candidate for this challenging condition.

TGFB1 Mutation Ups Radiation-Induced Breast Fibrosis Risk

C-509T allele and postoperative cosmetic surgery significantly linked to breast fibrosis risk.

Heat-Stable Carbetocin Safe Alternative to Oxytocin for Postpartum Hemorrhage Prevention

Heat-stable carbetocin — an analog of oxytocin — was found to be noninferior to oxytocin in preventing hemorrhage associated with vaginal birth and may be beneficial in low- and middle-income countries.

FDA Warns of the Dangers of 'Vaginal Rejuvenation'

Numerous cases of vaginal burns or scarring have been linked to the procedures.

Higher Risk of In Situ Breast CA, Ovarian Tumors With Fertility Treatment

No increased risk of corpus uteri, invasive breast cancer for women undergoing assisted reproduction.

2002 to 2014 Saw Hike in AMI Rate in Pregnancy, Puerperium

Rate of acute myocardial infarction one per 12,400 for those hospitalized during pregnancy, puerperium.

Postpartum Pain Management Recommendations From the American College of Obstetricians and Gynecologists

A committee from the American College of Obstetricians and Gynecologists formulated several recommendations for safely managing pain and fatigue in women during the early postpartum period.

Inactivated Influenza Vaccine Preferred for Nursing Mothers

Women receiving the inactivated influenza vaccine demonstrated superior antibody response compared with those receiving the live attenuated influenza vaccine.

FDA Grants First Approval for CA Drug Under New Pilot Programs

Ribociclib approved in combo with AI as endocrine tx for HR-positive, HER2-negative advanced breast CA.

HPV Vaccine Failure Rates May Be Higher in Women, Girls With HIV

Vaccinated women and girls living with HIV may be at greater risk for HPV vaccine failure compared with women and girls without HIV.

Lithium Use During Pregnancy Linked to Infant, Maternal Health Risks

Maternal lithium use in the first trimester of pregnancy may increase the risk for infant malformations.

Increased Maternal Mortality Risk Associated With Recurrent Preeclampsia

Recurrent hypertensive disease of pregnancy is associated with increased risk for early all-cause and some cause-specific mortality.

New Poll Offers Women's Perspective on Women's Health Issues

The Kaiser Family Foundation recently released results from a new poll examining the public's view on women's issues.

Congenital Anomalies Not Linked to Metformin Use After First Trimester

Metformin use during the first trimester of pregnancy is not correlated with an increased risk of congenital anomalies.

Prenatal Depression More Common in Young Moms Today

Depressed mood more common in young pregnant women today than in their mothers' generation.

Preeclampsia With Severe Features Increases Risk for Cardiac Abnormalities

Women with preeclampsia with severe features had increased right ventricular systolic pressure and decreased global right ventricular longitudinal systolic strain.

Decrease in Mean Platelet Counts Seen During Pregnancy

Platelet counts of 150,000/mm at time of delivery more common with pregnancy-related complications

Menopause Transition Often Prompts Changes in Migraine Pattern, Characteristics

This retrospective study sought to assess migraine patterns in 69 menopausal women between ages 40 and 60 who were treated at Partners Healthcare Hospitals for concurrent migraine headache.

Reproductive Dysfunction Risk in Women Taking Long-Term Opioids for Musculoskeletal Pain

Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.

Vitamin D and Gestational Hypertension, Preeclampsia Risk: Is There a Connection?

Researchers from the University of Bristol found no association between 25-hydroxyvitamin D level and pregnancy-related hypertensive disorders.

Follow-up Lacking for Women With Severe Maternal Morbidity

In New Zealand, large proportion did not receive event debrief, referral to social support or specialist

Menopausal Hormone Therapy Slows Cognitive Decline in Postmenopausal Women

Hormone therapy in postmenopausal women with mild cognitive impairment was examined.

Prenatal Pediatric Visit Recommended for Expectant Families

Visit provides unique opportunity to address relationship between family and pediatric practice.

Assessing a Comprehensive Long-Acting Reversible Contraceptive Program

An evaluation assessed the nonhealthcare-related influences that have led to misconceptions about long-acting reversible contraceptives.

Ribociclib Prolongs Progression-Free Survival in Premenopausal Breast Cancer

Investigators report results from the MONALEESA-7 trial, which assessed ribociclib plus endocrine therapy in premenopausal women with advanced breast cancer.

Early Preterm Birth Linked to Increased ADHD Symptoms

Association holds after adjustment for unmeasured genetic, environmental factors

Sex Hormone Levels May Affect Postmenopausal Heart Disease Risk

Researchers assessed the effect of testosterone, estradiol, dehydroepiandrosterone, and sex hormone-binding globulin levels on coronary heart disease, heart failure, and cardiovascular disease in postmenopausal women.

Exposure to Maternal HTN May Up Risk of ASD, ADHD in Child

Hypertensive disorders of pregnancy linked to risk of poorer neurodevelopmental outcomes in offspring

No Additional Benefits With Vaginal Estradiol Tablets, Moisturizers for Postmenopausal Vulvovaginal Symptoms

Prescribed vaginal estradiol tablets and over-the-counter vaginal moisturizers may not be more effective than placebos for postmenopausal vulvovaginal symptoms.

Nutraceuticals Containing Equol May Be Effective for Postmenopausal Symptoms

Equol-containing nutraceuticals may be beneficial for postmenopausal women with vaginal symptoms.

Many Breast Cancer Survivors Do Not Undergo Annual Surveillance

In year 1, 13% did not undergo MRI or mammography; up to 19% by year 5.

Imvexxy Approved for Moderate to Severe Dyspareunia Due to Menopause

The FDA approval was supported by findings from a Phase 3, randomized, double-blind, placebo-controlled study that evaluated Imvexxy (4mcg and 10mcg) vs placebo from baseline to week 12.

Hepatitis C-Exposed Infants Not Adequately Screened

Low screening rate seen at same time as increase in hepatitis C virus prevalence among pregnant women

Oral Contraceptive Taytulla Recalled Due to Packaging Error

A physician report indicates that 4 placebo (non-hormonal) capsules were placed in the first 4 days of therapy instead of active capsules.

Consensus Statement: Managing Bipolar Disorder During and After Pregnancy

Investigators summarize data regarding the management of bipolar disorder during pregnancy and in the postpartum period.

Major Depression in Males May Lower Chances of Conception

Active major depression in women not associated with negative fertility outcomes.

Effects of the Two Types of Anorexia Nervosa on Bone Metabolism

Investigators sought to determine whether both restrictive and purging types of anorexia nervosa effect bone metabolism.

Recommendations Developed for Managing Postpartum Pain

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

Diethylstilbestrol Use in Pregnancy Linked to Multigenerational Neurodevelopmental Deficits

Diethylstilbestrol exposure during pregnancy is associated with multigenerational neurodevelopmental deficits in childhood, including ADHD.

Increase in Proportion of Births at Gestational Age 39 to 40 Weeks

From 2007 to 2015 there was a decrease in perinatal mortality at gestational ages 39 to 40 weeks

Long-Term Cardiovascular Risk for Endometrial Cancer Survivors

Elevated risk of various cardiovascular outcomes, including pulmonary heart disease, atrial fibrillation

ACOG: Updated Recommendations for Influenza Vaccination During Pregnancy

This updated Committee Opinion includes more recent data on the safety and efficacy of influenza vaccination during pregnancy, as well as recommendations for treatment and postexposure chemoprophylaxis.

USPSTF Recommends Screening for Partner Violence in Reproductive-Aged Women

The USPSTF has found that screening for intimate partner violence is beneficial for reproductive-aged women, although there is inadequate evidence to weigh the balance of benefits and harms of screening for abuse in elderly and vulnerable adults.

Autism Linked to Prenatal Ultrasonography Depth

No statistically significant difference was observed in the number or duration of prenatal ultrasonographic scans across the entire pregnancy in children with later autism compared with controls with non-ASD developmental delay or typical development.

Number of IUD Insertions Increases After ACA Contraceptive Mandate

Increase in use depends on the amount of reduction in out-of-pocket costs

In Utero Exposure to Multiple AEDs, Sodium Valproate Linked to Poor Educational Attainment in Childhood

In utero exposure to AEDs in combination, or sodium valproate alone, is associated with a significant decrease in attainment in national educational tests for 7-year-old children.

Pap Tests May Help Diagnose Endometrial, Ovarian Cancers

Genetic mutations assays using PapSEEK may facilitate the detection of certain cancers using fluids from Pap tests.

Fatigue, muscle aches more common in women with HIV than men

The two most prevalent HIV symptoms, fatigue and muscle aches, are more common in women than men and can worsen with menopause.

Postpartum Depression Screening Effective in the Pediatric Setting

Standardizing postpartum depression screening in the ambulatory pediatric setting coupled with implementing a referral algorithm and referral guide can help more PPD cases be identified, further evaluated, and treated.

Childhood bullying, abuse may increase teen pregnancy risk

Bullying and maltreatment may be factors that explain the high pregnancy levels in teenage sexual minorities.

Metformin, statins not associated with ovarian cancer

The incidence of ovarian cancer was not related to metformin or statin usage among women with type 2 diabetes.

Medical schools on childbearing, family leave policies

Many medical schools provide paternity and maternity leaves, though the duration may among schools.

Over 7% of pregnant women smoked in 2016

Of the women who gave birth in 2016, over 7% smoked cigarettes while pregnant.

Cesarean delivery linked to long-term pregnancy complications

Cesarean delivery is associated with a reduced rate of urinary incontinence and pelvic organ prolapse, but this should be weighed against the association with increased risks for fertility, future pregnancy, and long-term childhood outcome.

USPSTF: Syphilis screenings recommended for pregnant women

The USPSTF reports that pregnant women can benefit from screening for syphilis infection.

Ovarian cancer screening: updated recommendations from the USPSTF

The USPSTF has issued an updated recommendation statement on ovarian cancer screening.

Laparoscopic hysterectomies increased in popularity from 2010 to 2013

Laparoscopy became the most common surgical approach for hysterectomy between 2010 and 2013, with associated changes in payments statistics for hysterectomy.

Multi-analyte blood test detects 8 common cancers

A multi-analyte blood test, CancerSEEK, can detect 8 common cancer types, with high sensitivity and specificity.

Early menarche, menopause linked to increased CVD risk

Several reproductive variables were independently linked to increased CVD risks.

BRCA might not affect young-onset breast cancer survival rates

Both patients with and without BRCA mutations have comparable survival rates.

Cancer risk in women who work night shifts long-term

For women who work night shifts, breast cancer risks increase by 3.3% for every 5 years of work.

Maternal folic acid, multivitamin use linked to reduced autism risk

Use of folic acid or multivitamins during pregnancy is associated with a significantly reduced risk of ASD in offspring.

Some infants are prematurely exposed to complementary foods

About 16% of infants under 4 months were fed foods other than breast milk or formula.

Early treatment of nausea, vomiting in pregnancy may prevent complications

Early treatment of nausea and vomiting of pregnancy can prevent complications.

Prenatal marijuana use increased from 2009 to 2016

Prenatal marijuana use increased from 2009 to 2016 for pregnant women of all ages.

Hormonal contraception use linked to an increased risk of breast cancer

Breast cancer diagnosis is higher among women who currently use or recently used contemporary hormonal contraceptives than among women who have never used hormonal contraceptives.

BMI may not indicate obesity in postmenopausal women

Body mass index BMI at a cut-point of 30 kg/m2 may not be an appropriate indicator of obesity in postmenopausal women.

Menopausal hormone therapy for chronic conditions: USPSTF's final recommendation

The USPSTF has updated its recommendations on the use of menopausal hormone therapy for the primary prevention of chronic conditions.

ADHD medication in pregnancy linked to few absolute increased risks

Women with significant attention-deficit/hyperactivity disorder do not need to stop treatment during pregnancy.

Prenatal ADHD treatment linked to neonatal morbidity

Treatment with ADHD medication during pregnancy was associated with a higher risk for neonatal morbidity, especially central nervous system-related disorders such as seizures.

CDC updates contraception recommendations for women at risk for HIV

The CDC revised its US Medical Eligibility Criteria for Contraceptive Use categorization for DMPA injection in women at high risk for HIV infection from US MEC category 1 to US MEC category 2.

Underweight women have high risk of early menopause

Early menopause risk is highest in weight-cycling and severely underweight women.

Delayed vs immediate cord clamping: comparing the impact on preterm infant health

Delayed and immediate umbilical cord clamping show no major differences in health of preterm infants.

ACOG issues recommendations for long-acting reversible contraception

The practice bulletin provides information for appropriate patient selection and evidence-based recommendations for intrauterine devices and contraceptive implants.

Diminished ovarian reserve not associated with infertility

Among women who are attempting to conceive naturally, diminished ovarian reserve is not associated with infertility.

Cervical cancer screening: recommendations from the USPSTF

The major change includes screening with hrHPV testing alone as an alternative to cytology screening alone starting at age 30 years.

Clinical practice guideline for antiretroviral therapy in pregnant women with HIV

Alternative treatments should be offered to pregnant women with HIV instead of tenofovir or emtricitabine.

Risk of premature birth, SGA with antiepileptic drugs

Women on AEDs during pregnancy are at a higher risk of delivering prematurely and giving birth to SGA newborns.

Pain during IUD insertion reduced with lidocaine nerve block

A 1% paracervical nerve block may be useful for reducing patient-reported pain during IUD insertion.

Hormone replacement therapy for menopause not associated with increased mortality risk

The researchers found no long-term increase in either all-cause or cause-specific mortality among women who received hormone therapy for up to 5.6 years or 7.2 years, depending on the type of therapy.

Breastfeeding associated with a lower risk of endometriosis

Duration of total and exclusive breastfeeding was significantly associated with a decreased risk of endometriosis.

Non-hormone options available for estrogen depletion after breast cancer

A variety of non-hormone options and therapies are available for treatment of estrogen-depletion symptoms and clinical problems after a diagnosis of breast cancer.

Annual mammography from age 40 decreases breast cancer mortality

Thousands of US lives would be saved each year if women received annual mammograms starting at age 40.

Anti-vaccine information during pregnancy could delay infant immunization

Information about vaccines received during pregnancy could influence infant immunization.

Previous cesarean delivery increases risk of complications after hysterectomy

Women with at least 1 previous cesarean delivery have an increased risk of complications when undergoing a hysterectomy.

Less than 10% of women present to the ER after hysterectomy for benign disease

Risk factors for emergency department visits include younger age, higher parity, Medicare or self-pay insurance, and postoperative pain.

Contraception and adolescents: ACOG releases counseling recommendations for clinicians

The ACOG released recommendations to help clinicians counsel adolescents about using contraception.

Telbivudine prevents hepatitis B transmission during early pregnancy

Telbivudine administered during early and middle pregnancy prevented hepatitis B transmission from mother to infants in all participants receiving antiviral treatment.

Maternal lifestyle interventions reduce the odds of cesarean section

Lifestyle interventions reduce gestational weight gain across various subgroups of women and lower the odds of cesarean section without affecting offspring outcomes.

Earlier menopause may increase risk of type 2 diabetes

Women who experienced early menopause were 2.4 times more likely to develop diabetes.

Aspirin effective in preventing preterm preeclampsia in women at high risk

Preterm preeclampsia occurred in 13 participants (1.6%) in the aspirin group, as compared with 35 (4.3%) in the placebo group.

Breast, ovarian cancer risks estimated for BRCA1/BRCA2 mutation carriers

Breast cancer risk is increased with a larger number of first- and second-degree relatives diagnosed as having breast cancer for both BRCA1/BRCA2 carriers.

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