Pain News Archive
American Headache Society Releases Position Statement on Novel Preventive and Acute Migraine Treatments
The American Headache Society has issued updated guidelines on the use of novel preventive and acute treatments for migraine in adults.
Pregnant women presenting with migraine to acute care settings were found to be treated with therapeutic agents ranging from safe and effective medications to others with unclear efficacy and potential teratogenicity.
Implementation of an ultrarestrictive protocol for opioid prescriptions was found to be associated with reductions in the amount of opioids prescribed after abdominal and gynecologic surgery.
Vitamin D3 may reduce migraine days in patients who experience frequent migraines.
Migraine with aura is associated with an elevated risk for incident atrial fibrillation.
For women with fibromyalgia, comorbid posttraumatic stress disorder may contribute to blunted cardiovascular reactivity to stress.
Prevalence of active migraine decreased linearly in the 24 years prior to diabetes diagnosis.
For opioid-naive patients, early physical therapy tied to less opioid use in shoulder, neck, knee, back pain.
But link between fiber intake and knee osteoarthritis was significant in only 1of 2 studies.
In adjusted analysis, smoking tied to worse symptom severity, sleep problems, anxiety, depression.
Eighty-five percent of patients report partial or complete resolution of headaches postoperatively.
The investigators sought to evaluate the prevalence of migraines, as well as the effect of sex and stress on migraines.
Individuals with chronic spinal pain, particularly those who are overweight or obese, may be less likely to recover from this condition if both their parents also have chronic spinal pain.
Data identified both clinical and employment factors that may predict poor work outcomes in patients with axial spondyloarthritis.
Prescription opioid misuse more likely for female respondents identifying as bisexual.
Highest average annual percentage of change from 2001 to 2015 seen for Estonia, then US.
Patients with greater trochanteric pain syndrome may have altered conditioned pain modulation, as well as a high number of pain locations associated with negative conditioned pain modulation.
Two screening tools, the STarT Back Screening Tool and the Örebro Musculoskeletal Pain Questionnaire, may be useful in predicting the transition from subacute and acute to chronic low back pain.
For adolescents with chronic pain, wait times to evaluation at an interdisciplinary pain clinic after referral were long and were associated with anxious anticipation and frustration from families.
Researchers and pain experts formulated guidelines for the use of onabotulinumtoxinA for the management of chronic migraine.
A stepped-care model of pain management implemented in primary care was successful in increasing the proportion of veteran patients reporting moderate to severe pain, as well as decreasing the use of opioids for pain management.
Narcan, Evzio chemically stable for at least 10 to 12 months after listed expiration dates.
The National Athletic Trainers' Association has issued recommendations for identifying and managing patients with patellofemoral pain.
Many patients in a workers' compensation cohort have persistent opioid use.
The clinical profiles of patients taking over-the-counter pain medications were found to be poorer than expected, with a high prevalence of migraine headache and many reporting frequent and disabling pain for extended durations.
Clinicians who prescribe gabapentin for off-label uses should assess available evidence for a given indication.
Advanced practice providers were found to prescribe more opioids and in larger quantities compared with other physicians.
Researchers developed a 4-phase life stress interview to determine whether women with chronic urogenital pain could derive benefits from disclosing stressors and gaining awareness of links between stress, emotions, and symptoms.
For patients with chronic sciatica, gabapentin is superior to pregabalin, with fewer and less severe adverse events.
Higher postoperative pain score, worse quality of life for post-op pain management with opioids.
A 7-item pain intensity measure for persons with dementia has shown initial validity and reliability.
Considerable proportion of healthy individuals without back pain have MRI positive for sacroiliitis.
Higher prevalence of chronic pain, high-impact chronic pain for women, older adults, rural residents.
Comprehensive bipartisan package earmarks billions of dollars to fight opioid abuse in the United States.
Cassipa combines buprenorphine, an opioid (partial agonist-antagonist), and naloxone, an opioid antagonist.
In a randomized control trial, researchers found that internet-delivered exposure therapy was more cost-effective for patients with fibromyalgia than a waitlist control, which did not involve any treatment during the experimental phase of the study.
Although literature indicates bidirectional associations between sleep disturbances and pain, few longitudinal studies have examined the role of sleep disturbances in contributing to chronic pain.
Integrating graded in vivo exposure into the management of chronic lower back pain may result in improved treatment efficacy and reduced pain-related fear.
Increase in mean OMEs filled in initial opioid rx after hydrocodone's change from schedule III to II.
The number of patients prescribed opioids and visiting an emergency department or requiring hospitalization decreased from 2009 to 2015.
Spinal manipulative therapy plus exercise more effective than exercise alone over 1-year period.
Dose-response association with highest odds of opioid-related death with high-dose pregabalin.
Children with abdominal pain commonly had clinically significant anxiety, moderate disability, pain.
A low-literacy, pain self-management program delivered one-on-one by a health educator or in groups with lectures from experts over a period of 6 months may improve chronic pain outcomes.
Differences exist in race and gender in patients with chronic lower back pain, especially in pain sensitivity and severity due to aftersensations from mechanical punctuate pain and deep muscle hyperalgesia.
Findings based on analysis of motorcycle accident victims by helmet use.
There is a lack of evidence supporting the benefits of combination drug therapy over monotherapy for the management of low back pain and sciatica.
Variation exists in opioid prescribing practices among clinicians in single-hospital systems, which prompts concern about the potential for opioid overprescribing.
Cumulative incidence of opioid-related adverse events was 38.3 per 100,000 prescriptions.
This novel agent has low permeability across the blood-brain barrier, which slows its rate of entry into the brain and reduces dopamine release.
Odds of pre-op opioid use up with age 31 to 40 years, tobacco use, illicit drug use, depression.
American emergency medicine physicians have been taking measures to address the ongoing opioid crisis, which affects emergency departments throughout the country.
Radiofrequency denervation, typically used to treat lumbar and cervical zygapophyseal joint pain, has shown efficacy in treating thoracic zygapophyseal joint pain.
Only 44 of parents would definitely go to ER if their child had headache that didn't improve with medication.
Investigators examined rates, predictors, and outcomes of neuroimaging in pediatric and adolescent patients who presented to the ED with a headache.
This retrospective study sought to assess migraine patterns in 69 menopausal women between ages 40 and 60 who were treated at Partners Healthcare Hospitals for concurrent migraine headache.
Surgeon General Jerome M. Adams, M.D., M.P.H., has urged more Americans to carry naloxone, an FDA-approved medication that can be delivered via nasal mist or injection and can temporarily suspend the effects of opioid overdose.
A panel discussion event held at the US Food and Drug Administration gathered patients with chronic pain and FDA officials, to reconcile concerns around prescriptions of opioid medications with the needs of these patient populations.
Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.
Commission makes 6 recommendations to meet 2030 goals for non-communicable diseases
In adults with sickle cell disease, higher daily opioid use may be associated with poorer health-related quality of life.
A study assessing the impact of upscheduling of hydrocodone combined medications on APRN practices in Oklahoma revealed significant barriers to effective pain management.
Researchers deployed a survey to individuals who had received treatment for opioid use disorder to assess their use of buprenorphine.
The phase 3 SUMMIT-07 trial assessed the safety, efficacy, and tolerability of a new mu-opioid receptor agonist analgesic in adults with moderate to severe chronic lower back pain.
Investigators assessed the potential for abuse associated with NKTR-181, a new mu-opioid receptor agonist analgesic.
A combination of naltrexone induction and psychoeducational counseling was found to facilitate transition from active opioid use and buprenorphine maintenance in individuals with opioid use disorder.
The budesonide extended-release formulation was found to be safe and well tolerated for the remission of ulcerative colitis, regardless of age or gender.
The Company indicated that they will work towards an New Drug Application submission for the treatment in the second half of 2018.
Pediatric exposure to buprenorphine can result in serious adverse outcomes, especially among children aged younger than 6 years.
Belief in a long recovery, many symptoms attributed to pain negatively tied to improvement
Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality
In patients receiving opioid substitution treatment for opioid use disorder (mainly involving heroin), those exhibiting a rapid decline in heroin use were found to be more likely to have successful treatment outcomes.
Electrical pulses are sent through small needles that are inserted in the ear to combat the early stages of detoxification, leading to stabilization.
Patients with migraine may exhibit higher prevalence of restless leg syndrome, fibromyalgia, and depressive symptoms compared with individuals not experiencing migraines.
Adding corticosteroids to epidural lidocaine injections does not improve patient-reported pain or function at 12 months.
The U.S. Food and Drug Administration has issued warnings to 9 online companies selling illegal opioid medications on 53 websites, in direct violation of the Federal Food, Drug, and Cosmetic Act.
Cryoablation also cuts the need for opioids at 24 hours post-treatment and at three months
Burden of deaths up; most patients receiving opioid analgesics use immediate-release formulations
Posttraumatic stress disorder symptoms may be associated with higher levels of acute pain and pain interference in low-income inner city women.
Lucemyra is an oral selective alpha 2-adrenergic receptor agonist
The efficacy of Aimovig was evaluated as a preventive treatment of episodic or chronic migraine in 3 randomized, double-blind, placebo-controlled studies: 2 studies in patients with episodic migraine (4-14 migraine days per month) and 1 study in patients with chronic migraine (≥15 headache days per month with ≥8 migraine days per month).
Improvements in low back pain intensity and disability among active-duty military personnel
Oral medication, botulinum toxin type A injections, and endoscopic decompression surgery were all compared in the treatment of patients with frontal secondary headaches due to STN and SON configuration.
Investigators examined presenting features of migraine vs arterial ischemic stroke in children presenting to the emergency department.
Many patients reported unsafe storage and failure to dispose of opioids at one- and 6-month follow-up
Individuals with chronic vs episodic migraine may be more likely to experience chronic back pain, chronic pain, neck pain, anxiety, and depression.
From 2010 to 2016, synthetic opioid involvement up from 14.3 to 45.9% of opioid-related deaths
Intrathecal drug delivery systems and spinal cord stimulation have shown promise for the treatment of cancer pain in initial studies.
Based on data from multiple sources, many opioid-overdose deaths seem to be suicides
The use of high doses of opioids — particularly long-acting opioids — during surgery may increase the risk for 30-day readmission.
At discharge, 92.2% of patients received an opioid prescription; nearly 63% unused
Post-op pain strongly linked to number of classes of non-opioid analgesics used, remifentanil use
It is important for clinicians to quickly and accurately determine potential underlying causes and to prescribe treatments that take into account comorbidities and medications that older patients may be taking for them.
Lower numeric rating scale pain scores on ambulation on postoperative days zero, one, and two
Heavy use in Crohn's, heavy or moderate use in ulcerative colitis tied to increased risk of death
Group cognitive behavioral therapy and pain education may be more effective than usual care for improving pain and physical function in patients presenting with chronic pain at low-income clinics.
Tai chi interventions may be more effective at treating fibromyalgia than aerobic exercise.
FDA has called on social media companies and internet service providers to take a proactive approach in curbing online selling of opioids through their platforms.
The two most prevalent HIV symptoms, fatigue and muscle aches, are more common in women than men and can worsen with menopause.
The rate of ER visits for suspected opioid-related overdoses has increased by a mean of 5.6% per quarter.