Pain News Archive

American Headache Society Releases Position Statement on Novel Preventive and Acute Migraine Treatments

The American Headache Society has issued updated guidelines on the use of novel preventive and acute treatments for migraine in adults.

Treating Acute Migraine During Pregnancy: The Need for Guidelines

Pregnant women presenting with migraine to acute care settings were found to be treated with therapeutic agents ranging from safe and effective medications to others with unclear efficacy and potential teratogenicity.

Ultrarestrictive Opioid Prescription Protocol May Be Effective for Postoperative Pain Management

Implementation of an ultrarestrictive protocol for opioid prescriptions was found to be associated with reductions in the amount of opioids prescribed after abdominal and gynecologic surgery.

Vitamin D3 Associated With Reductions in Migraine Days Among Migraineurs

Vitamin D3 may reduce migraine days in patients who experience frequent migraines.

Migraine With Aura Linked to Increase in Incident A-Fib

Migraine with aura is associated with an elevated risk for incident atrial fibrillation.

Blunted Cardiovascular Stress Reactivity in Fibromyalgia With Comorbid PTSD

For women with fibromyalgia, comorbid posttraumatic stress disorder may contribute to blunted cardiovascular reactivity to stress.

Type 2 Diabetes Risk Lower in Women With Active Migraine

Prevalence of active migraine decreased linearly in the 24 years prior to diabetes diagnosis.

Early PT Linked to Less Opioid Use in Musculoskeletal Pain

For opioid-naive patients, early physical therapy tied to less opioid use in shoulder, neck, knee, back pain.

BMI May Mediate Inverse Link Between Fiber Intake, Knee Osteoarthritis

But link between fiber intake and knee osteoarthritis was significant in only 1of 2 studies.

Smoking Linked to Cognitive Dysfunction in Fibromyalgia

In adjusted analysis, smoking tied to worse symptom severity, sleep problems, anxiety, depression.

Functional Nasal Surgery Can Improve Headache Symptoms

Eighty-five percent of patients report partial or complete resolution of headaches postoperatively.

High Daily Stress Linked to Migraine Prevalence in Women

The investigators sought to evaluate the prevalence of migraines, as well as the effect of sex and stress on migraines.

Parental Chronic Spinal Pain May Affect Prognosis in Adult Offspring

Individuals with chronic spinal pain, particularly those who are overweight or obese, may be less likely to recover from this condition if both their parents also have chronic spinal pain.

Workplace, Clinical Factors Linked to Employment Outcomes in Axial Spondyloarthritis

Data identified both clinical and employment factors that may predict poor work outcomes in patients with axial spondyloarthritis.

Opioid Misuse Varies With Sexual Orientation

Prescription opioid misuse more likely for female respondents identifying as bisexual.

Drug Overdose Mortality Rates Highest in United States

Highest average annual percentage of change from 2001 to 2015 seen for Estonia, then US.

Central Sensitization in Greater Trochanteric Pain Syndrome

Patients with greater trochanteric pain syndrome may have altered conditioned pain modulation, as well as a high number of pain locations associated with negative conditioned pain modulation.

Two Screening Tools May Accurately Predict Transition From Acute to Chronic Low Back Pain

Two screening tools, the STarT Back Screening Tool and the Örebro Musculoskeletal Pain Questionnaire, may be useful in predicting the transition from subacute and acute to chronic low back pain.

Long Wait Times Between Referral and Interdisciplinary Pediatric Chronic Pain Evaluation

For adolescents with chronic pain, wait times to evaluation at an interdisciplinary pain clinic after referral were long and were associated with anxious anticipation and frustration from families.

Guidelines on the Use of OnabotulinumtoxinA for Chronic Migraine

Researchers and pain experts formulated guidelines for the use of onabotulinumtoxinA for the management of chronic migraine.

Stepped-Care Model Beneficial in Pain Management Practices in Primary Care

A stepped-care model of pain management implemented in primary care was successful in increasing the proportion of veteran patients reporting moderate to severe pain, as well as decreasing the use of opioids for pain management.

Naloxone Products Stay Effective Long After Expiration Date

Narcan, Evzio chemically stable for at least 10 to 12 months after listed expiration dates.

New Guidelines Issued for Patellofemoral Pain Management

The National Athletic Trainers' Association has issued recommendations for identifying and managing patients with patellofemoral pain.

Opioid Use Often Persists in Workers' Compensation Claimants

Many patients in a workers' compensation cohort have persistent opioid use.

OTC Analgesic Use High, Associated With Worse-Than-Expected Clinical Profiles

The clinical profiles of patients taking over-the-counter pain medications were found to be poorer than expected, with a high prevalence of migraine headache and many reporting frequent and disabling pain for extended durations.

Little Evidence of Gabapentin Efficacy for Off-Label Uses

Clinicians who prescribe gabapentin for off-label uses should assess available evidence for a given indication.

Clinician Characteristics Associated With Outpatient Postoperative Opioid Prescribing

Advanced practice providers were found to prescribe more opioids and in larger quantities compared with other physicians.

Encouraging Emotional Awareness, Expression of Life Stress in Women With Chronic Urogenital Pain

Researchers developed a 4-phase life stress interview to determine whether women with chronic urogenital pain could derive benefits from disclosing stressors and gaining awareness of links between stress, emotions, and symptoms.

Gabapentin Superior to Pregabalin for Chronic Sciatica

For patients with chronic sciatica, gabapentin is superior to pregabalin, with fewer and less severe adverse events.

ASA: Review Links Opioids With Complications Post-Spine Surgery

Higher postoperative pain score, worse quality of life for post-op pain management with opioids.

Seven-Item Pain Intensity Measure Reliable in Individuals With Dementia

A 7-item pain intensity measure for persons with dementia has shown initial validity and reliability.

MRI Indicates Sacroiliitis in Some Healthy Individuals

Considerable proportion of healthy individuals without back pain have MRI positive for sacroiliitis.

CDC: About One in 5 US Adults Has Chronic Pain

Higher prevalence of chronic pain, high-impact chronic pain for women, older adults, rural residents.

US Senate Passes Opioids Bill

Comprehensive bipartisan package earmarks billions of dollars to fight opioid abuse in the United States.

Cassipa Approved as Maintenance Treatment for Opioid Dependence

Cassipa combines buprenorphine, an opioid (partial agonist-antagonist), and naloxone, an opioid antagonist.

Internet-Delivered Exposure Therapy Cost-Effective for Patients With Fibromyalgia

In a randomized control trial, researchers found that internet-delivered exposure therapy was more cost-effective for patients with fibromyalgia than a waitlist control, which did not involve any treatment during the experimental phase of the study.

Call to Better Investigate the Associations Between Sleep Disturbances and Chronic Pain

Although literature indicates bidirectional associations between sleep disturbances and pain, few longitudinal studies have examined the role of sleep disturbances in contributing to chronic pain.

Graded In Vivo Exposure Elements May Benefit Chronic Lower Back Pain Management

Integrating graded in vivo exposure into the management of chronic lower back pain may result in improved treatment efficacy and reduced pain-related fear.

Hydrocodone Schedule Change Affected Post-Op Opioid Rx

Increase in mean OMEs filled in initial opioid rx after hydrocodone's change from schedule III to II.

Opioid-Related Emergency Department Visits, Hospitalization Rates Decrease From 2009 to 2015

The number of patients prescribed opioids and visiting an emergency department or requiring hospitalization decreased from 2009 to 2015.

Spinal Manipulation Plus Exercise Effective for Teen Low Back Pain

Spinal manipulative therapy plus exercise more effective than exercise alone over 1-year period.

Odds of Death Up With Exposure to Pregabalin, Opioids

Dose-response association with highest odds of opioid-related death with high-dose pregabalin.

Psych Screening Beneficial in Pediatric Abdominal Pain

Children with abdominal pain commonly had clinically significant anxiety, moderate disability, pain.

Low Literacy Self-Management Program for Chronic Pain May Be Effective

A low-literacy, pain self-management program delivered one-on-one by a health educator or in groups with lectures from experts over a period of 6 months may improve chronic pain outcomes.

Chronic Low Back Pain Levels Vary Between Sex and Race

Differences exist in race and gender in patients with chronic lower back pain, especially in pain sensitivity and severity due to aftersensations from mechanical punctuate pain and deep muscle hyperalgesia.

Fewer Cervical Spine Injuries Seen With Motorcycle Helmet Use

Findings based on analysis of motorcycle accident victims by helmet use.

Combination Therapies for Low Back Pain, Sciatica May Not Have Added Benefit

There is a lack of evidence supporting the benefits of combination drug therapy over monotherapy for the management of low back pain and sciatica.

Wide Variations in Opioid Prescribing Practices for Surgical Procedures

Variation exists in opioid prescribing practices among clinicians in single-hospital systems, which prompts concern about the potential for opioid overprescribing.

Outpatient Opioid Prescriptions for Children Often Filled

Cumulative incidence of opioid-related adverse events was 38.3 per 100,000 prescriptions.

FDA to Review Novel Opioid Analgesic for Chronic Low Back Pain

This novel agent has low permeability across the blood-brain barrier, which slows its rate of entry into the brain and reduces dopamine release.

Preoperative Opioids Used by Nearly One-Quarter of Surgical Patients

Odds of pre-op opioid use up with age 31 to 40 years, tobacco use, illicit drug use, depression.

Emergency Physicians Offer Recommendations for Identifying and Managing Opioid Use Disorder

American emergency medicine physicians have been taking measures to address the ongoing opioid crisis, which affects emergency departments throughout the country.

Radiofrequency Denervation Efficacious in Treating Thoracic Zygapophyseal Joint Pain

Radiofrequency denervation, typically used to treat lumbar and cervical zygapophyseal joint pain, has shown efficacy in treating thoracic zygapophyseal joint pain.

Two-Thirds of Parents Report Their Child Has Had Headache

Only 44 of parents would definitely go to ER if their child had headache that didn't improve with medication.

Overuse of Neuroimaging in the Emergency Department Reported for Pediatric Headache

Investigators examined rates, predictors, and outcomes of neuroimaging in pediatric and adolescent patients who presented to the ED with a headache.

Menopause Transition Often Prompts Changes in Migraine Pattern, Characteristics

This retrospective study sought to assess migraine patterns in 69 menopausal women between ages 40 and 60 who were treated at Partners Healthcare Hospitals for concurrent migraine headache.

US Surgeon General Urges More Americans to Carry Naloxone

Surgeon General Jerome M. Adams, M.D., M.P.H., has urged more Americans to carry naloxone, an FDA-approved medication that can be delivered via nasal mist or injection and can temporarily suspend the effects of opioid overdose.

FDA Takes Steps to Reconcile Needs of Patients With Chronic Pain, Efforts to Curb Opioid Epidemic

A panel discussion event held at the US Food and Drug Administration gathered patients with chronic pain and FDA officials, to reconcile concerns around prescriptions of opioid medications with the needs of these patient populations.

Reproductive Dysfunction Risk in Women Taking Long-Term Opioids for Musculoskeletal Pain

Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.

WHO Calls for Renewed Effort to Combat Chronic Disease

Commission makes 6 recommendations to meet 2030 goals for non-communicable diseases

Chronic Pain Leads to Higher Opioid Doses and Lower QoL in Sickle Cell Patients

In adults with sickle cell disease, higher daily opioid use may be associated with poorer health-related quality of life.

FDA Upscheduling of Hydrocodone Places Burden on APRNs

A study assessing the impact of upscheduling of hydrocodone combined medications on APRN practices in Oklahoma revealed significant barriers to effective pain management.

Buprenorphine Diversion Driven by Withdrawal Prevention, Abstinence Maintenance

Researchers deployed a survey to individuals who had received treatment for opioid use disorder to assess their use of buprenorphine.

NKTR-181 for Chronic Lower Back Pain: SUMMIT-07 Results

The phase 3 SUMMIT-07 trial assessed the safety, efficacy, and tolerability of a new mu-opioid receptor agonist analgesic in adults with moderate to severe chronic lower back pain.

Oxycodone Substitute Shows Lower Abuse Potential

Investigators assessed the potential for abuse associated with NKTR-181, a new mu-opioid receptor agonist analgesic.

Transition to Naltrexone in Opioid Use Disorder Benefits from Psychosocial Assessment

A combination of naltrexone induction and psychoeducational counseling was found to facilitate transition from active opioid use and buprenorphine maintenance in individuals with opioid use disorder.

Budesonide ER for Ulcerative Colitis Safe Regardless of Gender, Age

The budesonide extended-release formulation was found to be safe and well tolerated for the remission of ulcerative colitis, regardless of age or gender.

Post-Op Pain Treatment Gets Breakthrough Therapy Designation

The Company indicated that they will work towards an New Drug Application submission for the treatment in the second half of 2018.

Poison Control Center Data Detail Pediatric Exposure to Buprenorphine

Pediatric exposure to buprenorphine can result in serious adverse outcomes, especially among children aged younger than 6 years.

Various Factors Affect Progress in Back-Related Leg Pain, Sciatica

Belief in a long recovery, many symptoms attributed to pain negatively tied to improvement

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

Rapid Decreasing Heroin Use During Opioid Substitution Treatment Associated With Treatment Success

In patients receiving opioid substitution treatment for opioid use disorder (mainly involving heroin), those exhibiting a rapid decline in heroin use were found to be more likely to have successful treatment outcomes.

Wearable Device Cleared for Use During Opioid Detoxification

Electrical pulses are sent through small needles that are inserted in the ear to combat the early stages of detoxification, leading to stabilization.

Restless Legs Syndrome, Fibromyalgia, and Depression Frequent in Migraine

Patients with migraine may exhibit higher prevalence of restless leg syndrome, fibromyalgia, and depressive symptoms compared with individuals not experiencing migraines.

Corticosteroid Plus Lidocaine Injections Do Not Alleviate Pain in Central Lumbar Spinal Stenosis

Adding corticosteroids to epidural lidocaine injections does not improve patient-reported pain or function at 12 months.

FDA Cracks Down on Illegal Online Sales of Opioids

The U.S. Food and Drug Administration has issued warnings to 9 online companies selling illegal opioid medications on 53 websites, in direct violation of the Federal Food, Drug, and Cosmetic Act.

Cryoablation Efficacious for Cancer Pain, Review Finds

Cryoablation also cuts the need for opioids at 24 hours post-treatment and at three months

Studies ID Impact of US Opioid-Related Mortality, Prescription Patterns

Burden of deaths up; most patients receiving opioid analgesics use immediate-release formulations

PTSD Symptoms and the Acute Pain Response in Low-Income Women

Posttraumatic stress disorder symptoms may be associated with higher levels of acute pain and pain interference in low-income inner city women.

FDA Approves Non-Opioid Treatment for Opioid Withdrawal

Lucemyra is an oral selective alpha 2-adrenergic receptor agonist

First-of-Its-Kind Migraine Drug Receives FDA Approval

The efficacy of Aimovig was evaluated as a preventive treatment of episodic or chronic migraine in 3 randomized, double-blind, placebo-controlled studies: 2 studies in patients with episodic migraine (4-14 migraine days per month) and 1 study in patients with chronic migraine (≥15 headache days per month with ≥8 migraine days per month).

Adding Chiropractic to Usual Care Beneficial for Low Back Pain

Improvements in low back pain intensity and disability among active-duty military personnel

Patients with Frontal Chronic Headaches May Benefit from Endoscopic Decompression Surgery

Oral medication, botulinum toxin type A injections, and endoscopic decompression surgery were all compared in the treatment of patients with frontal secondary headaches due to STN and SON configuration.

Discerning Arterial Ischemic Stroke From Migraine in Pediatric Emergency Departments

Investigators examined presenting features of migraine vs arterial ischemic stroke in children presenting to the emergency department.

Many Patients Have Unused Opioids After Spine, Joint Surgery

Many patients reported unsafe storage and failure to dispose of opioids at one- and 6-month follow-up

Pain, Psychiatric Comorbidities More Common in Chronic vs Episodic Migraine

Individuals with chronic vs episodic migraine may be more likely to experience chronic back pain, chronic pain, neck pain, anxiety, and depression.

Synthetic Opioid Involvement in Opioid-Related Deaths Increases

From 2010 to 2016, synthetic opioid involvement up from 14.3 to 45.9% of opioid-related deaths

Intrathecal Drug Delivery and Spinal Cord Stimulation for Cancer Pain: A Review

Intrathecal drug delivery systems and spinal cord stimulation have shown promise for the treatment of cancer pain in initial studies.

People With Opioid Use Disorder Have High Suicide Rate

Based on data from multiple sources, many opioid-overdose deaths seem to be suicides

Intraoperative Opioid Doses and Rates of Hospital Readmission

The use of high doses of opioids — particularly long-acting opioids — during surgery may increase the risk for 30-day readmission.

Study Finds 31% Use No Opioids After Surgery

At discharge, 92.2% of patients received an opioid prescription; nearly 63% unused

Eight Factors Predict Pain After Spine Surgery

Post-op pain strongly linked to number of classes of non-opioid analgesics used, remifentanil use

Headache in Older Adults: Unique Causes and Treatments

It is important for clinicians to quickly and accurately determine potential underlying causes and to prescribe treatments that take into account comorbidities and medications that older patients may be taking for them.

Addition of Peripheral Nerve Blocks Beneficial for TKA

Lower numeric rating scale pain scores on ambulation on postoperative days zero, one, and two

Opiate Use Linked to Early Mortality in IBD Patients

Heavy use in Crohn's, heavy or moderate use in ulcerative colitis tied to increased risk of death

CBT vs Pain Education for Chronic Pain in Low-Income Clinics

Group cognitive behavioral therapy and pain education may be more effective than usual care for improving pain and physical function in patients presenting with chronic pain at low-income clinics.

Tai Chi May Be Therapeutic Option for Fibromyalgia

Tai chi interventions may be more effective at treating fibromyalgia than aerobic exercise.

FDA: Social Media Companies Are Not Doing Enough to Stop Illegal Opioid Sales

FDA has called on social media companies and internet service providers to take a proactive approach in curbing online selling of opioids through their platforms.

Fatigue, muscle aches more common in women with HIV than men

The two most prevalent HIV symptoms, fatigue and muscle aches, are more common in women than men and can worsen with menopause.

CDC reports opioid-related overdoses have increased from July 2016 to Sept 2017

The rate of ER visits for suspected opioid-related overdoses has increased by a mean of 5.6% per quarter.

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