Print Issue: January 10, 2007

DIPHENHYDRAMINE MORE EFFECTIVE THAN desloratadine OR PLACEBO FOR SEASONAL ALLERGIC RHINITIS

Level 1: Likely reliable evidence Diphenhydramine (Benadryl) and desloratadine (Clarinex) were evaluated in a double-blind trial of 610 patients ages 12-65 years with moderate-to-severe seasonal allergic rhinitis (Ann Allergy Asthma Immunol. 2006;96:606-614). Participants were randomized to diphenhydramine 50 mg three times daily, desloratadine 5 mg once daily, or placebo for one week. A total of…

VITAMIN K APPEARS TO REDUCE POSTMENOPAUSAL FRACTURE RATES

Level 2: Mid-level evidence All women who are at risk for osteoporosis should receive counseling regarding universal preventive measures related to fracture risk, including calcium and vitamin D intake, weight-bearing exercise, smoking cessation, and avoidance of excess alcohol intake. Additional options for preventing osteoporosis continue to be an important research topic, including treatment with estrogen,…

NUMERICAL SCORING SYSTEM MAY HELP DIAGNOSE HEART FAILURE IN COPD PATIENTS

Level 2: Mid-level evidence A numerical scoring system may be useful for diagnosing heart failure in elderly patients with stable chronic obstructive pulmonary disease (COPD) (BMJ. 2005;331:1379; full text available free of charge athttp://bmj.bmjjournals.com/cgi/content/full/331/7529/1379, accessed December 7, 2006). The system was derived from a study of 405 participants at least 65 years of age who…

Depression torpedoes asthma therapy

Frustrated with your adult asthma patients’ poor adherence to their treatment regimens? They may suffer clinical depression, and if you treat it, their asthma might improve. This conclusion comes from two related but separate studies. In the first, investigators at The Johns Hopkins School of Medicine in Baltimore studied 59 middle-aged, inner-city adults hospitalized for…

Combo therapy reduces COPD death

Using two asthma drugs as combined therapy reduces mortality among patients with chronic obstructive pulmonary disease (COPD) more than one drug alone, according to the largest COPD trial ever done. Researchers in the United States and several European countries randomized 6,112 patients (aged 40-80 years) with moderate-to-severe COPD to placebo, the long-acting bronchodilator salmeterol (50…

Statins benefit heart failure patients

Heart failure patients treated with statins experience a reduced risk of death and hospitalization, even if they also suffer from coronary heart disease (CHD), new data show. A team of researchers in California studied 24,598 patients diagnosed with heart failure who had not previously used statin drugs. At a median 2.4 years’ follow-up — and…

Too many colonoscopies?

Evidence shows that clinicians recommend post-polypectomy colonoscopies more often than necessary.

Predicting a 2nd stroke

Measuring two key inflammatory markers in the blood may help clinicians determine patients’ post-stroke prognosis more accurately than using either marker alone, say investigators at Columbia University in New York City. Levels of high-sensitivity C-reactive protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) were measured in 467 patients (mean age 69) who were admitted with their…

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