May 01, 2009 Archives - Clinical Advisor

Print Issue: May 01, 2009

Routine immediate imaging may yield no benefit for acute low back pain

Level 2: Mid-level evidenceAlthough lumbar imaging for acute low back pain is generally indicated only if there is concern for serious underlying disease (e.g., infection, malignancy), many physicians continue to order imaging studies on a routine basis for these patients. In support of previous research, a recent systematic review of six randomized trials evaluating immediate…

Why the prostate grows with age

Absent malignancy, most tissues in the body shrink as we age. Why does the prostate expand as men grow old?—Kishan Agarwal, MD, Edison, N.J. What a great question. The size of any organ will be dependent on the equilibrium between cell division and cell death. It turns out that androgens not only are required for…

Antipsychotic meds associated with reduced survival in patients with Alzheimer’s disease

Level 2: Mid-level evidenceIn April 2008, the Dementia Antipsychotic Withdrawal Trial (DART-AD) showed that stopping antipsychotic treatment did not worsen cognitive, functional, or behavioral status in most elderly patients with Alzheimer’s disease (PLoS Med. 2008;5:e76; accessed April 8, 2009). Based on results of short-term trials that indicated an increased mortality risk, the FDA has previously…

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