Level 2: Mid-level evidence Advice to use a topical nonsteroidal anti-inflammatory drug (NSAID) and advice to use an oral NSAID appear to have similar effects on chronic knee pain at one year, based on a non-placebo-controlled randomized trial (BMJ. 2008;336: 138-142). Patients older than 50 years with knee pain (N=282) were randomized to advice to…
Nonsteroidal anti-inflammatory drugs have been linked with increased risk for atrial fibrillation and adverse events in patients with hypertension and coronary artery disease.
Regular use of NSAIDs resulted in no significant reduction in squamous cell carcinoma risk
A number of my older patients who take a daily aspirin have been told in the past that they could not take a nonsteroidal anti-inflammatory drug (NSAID) as well. Is there any evidence that NSAIDs will reduce the effectiveness of aspirin? Similarly, is there any evidence that warfarin (Coumadin) therapy will be affected by NSAID…
Although aspirin and other NSAIDS are thought to protect against some types of cancer, new data suggests that non-aspirin NSAIDs may increase the risk for renal cell carcinoma.
Allergy and Immunology Information Center
Patients with low back pain or osteoarthritis who reported adverse drug reactions to nonsteroidal anti-inflammatory drugs have significantly higher odds of receiving prescriptions for opioids and developing opioid use disorder.
Readers provide more suggestions for treating musculoskeletal pain.
Clinicians should be aware of cardiovascular risks with NSAIDs and COX-2 inhibitors.
A large, ethnically diverse study has linked the regular use of nonsteroidal anti-inflammatory drugs with erectile dysfunction beyond what would be expected due to age and comorbidity.
Level 1: Likely reliable evidence Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used for the treatment of acute gout. The efficacy of NSAIDs compared with prednisolone was evaluated in a randomized trial of 90 patients older than 17 years with a clinical diagnosis of goutlike arthritis (Ann Emerg Med. 2007;49:670-677). Patients were randomized within three days…