Two cases of male patients with a worsening rash are presented; can you diagnose the conditions?
Be aware of the risk for Stevens-Johnson syndrome, toxic epidermal necrolysis and acute generalized exanthematous pustulosis with acetaminophen.
OVERVIEW: What every practitioner needs to know# Are you sure your patient has Stevens–Johnson syndrome/toxic epidermal necrolysis? What should you expect to find? Stevens–Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe reactive blistering diseases along a continuum of disease severity. They are uncommon to rare conditions in the general population with increased incidence…
Are You Confident of the Diagnosis? What you should be alert for in the history Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe and sometimes life-threatening dermatoses that are caused by medication. They are characterized by sometimes extensive detachment of the epidermis and mucosal epithelia. The time to onset of the eruption is…
Dangerous or even fatal skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis) with carbamazepine (Tegretol, Carbatrol) are significantly more common in patients with the HLA allele B*1502, based on an FDA MedWatch notice and FDA Press Release (FDA MedWatch 2007 December 12; full-text available online at: www.fda.gov/medwatch/safety/2007/safety07.htm#carbamazepine, FDA Press Release 2007 Dec 12; full-text available…
The FDA's Antiviral Drugs Advisory Committee unanimously voted that a second protease inhibitor, telaprevir, is safe and effective for treating patients with hepatitis C virus genotype 1.
One clinician misdiagnoses an adverse effect of a drug prescribed by another.
A Bronx jury awarded close to $120 million to a woman who suffered brain damage after being treated at three New York area hospitals.
The FDA has approved telaprevir (Incivek, Vertex), the second direct acting protease inhibitor to be granted agency approval this month to treat adults with chronic hepatitis C infections.
A 26-year-old man presents with asymptomatic blisters on his hands, arms, and feet that have been present for 4 days.