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Evidence-Based Medicine


Dangerous or even fatal skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis) with carbamazepine (Tegretol, Carbatrol) are significantly more common in patients with the HLA allele B*1502, based on an FDA MedWatch notice and FDA Press Release (FDA MedWatch 2007 December 12; full-text available online at:, FDA Press Release 2007 Dec 12; full-text available…
Web Exclusives

FDA panel gives second hepatitis C drug green light

The FDA's Antiviral Drugs Advisory Committee unanimously voted that a second protease inhibitor, telaprevir, is safe and effective for treating patients with hepatitis C virus genotype 1.
Web Exclusives

Telaprevir gets FDA nod for hepatitis C

The FDA has approved telaprevir (Incivek, Vertex), the second direct acting protease inhibitor to be granted agency approval this month to treat adults with chronic hepatitis C infections.
Drug Update

Flector Patch- Patch relieves pain of sprains, contusions

Product: Flector Patch Company: Alpharma Pharmacologic class: Topical analgesic (nonsteroidal anti-inflammatory drug [NSAID]) Continue Reading Active ingredient: Diclofenac epolamine 180 mg; per patch. Indication: Topical treatment of acute pain due to minor strains, sprains, and contusions. Pharmacology: Flector is a topical patch that contains 1.3% of diclofenac epolamine, an NSAID. It measures approximately 10 x14…
Clinical Challenge

Case Study: A gradually progressive rash after a URI

A 33-year-old man presents to the emergency department for 6 small spots on his chest, arms, and legs that gradually grew in diameter after using a topical cream and cephalexin.
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