Your search for opioid-induced constipation returned 10 results

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Drug Update

PAMORA for opioid-induced constipation

Naloxegol functions as a peripherally acting mu-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby decreasing the constipating effects of opioids.
Evidence-Based Medicine

Methylnaltrexone may relieve opioid-induced constipation

Compared with placebo, methylnaltrexone yielded a higher rate of bowel movement without laxative within four hours of first dose, within four hours after two or more of the first four doses, within four hours after four or more of the first seven doses, and after one or more of seven doses.
Drug Update

Injection for opioid-induced constipation

Product: Relistor Company: Wyeth  Pharmacologic class: Opioid antagonist (peripheral) Active ingredient: Methylnaltrexone bromide 12 mg/0.6 mL; solution for subcutaneous (SC) injection Continue Reading Indication: Opioid-induced constipation Pharmacology: The use of opioid analgesics can lead to constipation due to their effect on intestinal smooth muscle and their interference with the bowel’s normal elimination function. Methylnaltrexone bro-mide…
Web Exclusives

Constipation: Diagnosis and treatment overview

Strong evidence for efficacy has been established for stimulant and osmotic laxatives, new intestinal secretagogues, and peripherally restricted μ-opiate receptor antagonists, according to a review in JAMA.
Gastroenterology Information Center

Irritable Bowel Syndrome and Vitamin D: Is There a Connection?

Low vitamin D levels have been linked to multiple diseases including some cancers, neurologic disorders, decrease in bone density, and cognitive decline in the elderly, and research suggests that a possible inflammatory response in the gut when vitamin D levels are low may cause irritable bowel syndrome.
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