Clovers trial seeks to determine which IV fluids, vasopressors combo works best to curb sepsis.
The use of corticosteroids in sepsis appears to modestly reduce the risk for death and modestly increase neuromuscular weakness but the evidence is not definitive.
Completion of a care bundle for pediatric patients within 1 hour of sepsis recognition, which includes blood cultures, broad-spectrum antibiotics, and a 20-mL/kg intravenous fluid bolus, was associated with lower in-hospital mortality among children with sepsis and septic shock
However, completing individual bundle elements in that timeframe does not reduce pediatric mortality.
No moderate- or high-level evidence was found that SEP-1 or its hemodynamic interventions increase survival in septic adults.
Hydrocortisone treatment does not effectively reduce mortality in sepsis.
Patients with septic shock taking phenylephrine during the 2011 norepinephrine shortage experienced higher in-hospital mortality rates.
Short-term oral corticosteroid use associated with increased risk for sepsis, venous thromboembolismApril 27, 2017
Approximately 1 in 5 American adults use corticosteroids in the short term, which is associated with an increased risk for sepsis, venous thromboembolism, and fracture.
Early, goal-directed therapy did not result in better outcomes for mortality for patients with septic shock.
Data presented at NAPNAP show that an early-onset sepsis calculator can decrease the number of infants who received a sepsis work-up and prophylactic antibiotics.
Sepsis should be defined as life-threatening organ dysfunction as a response to infection.