Frigid weather conditions in many parts of the world are causing an increase in cold-weather injuries like frostbite. These three images show the progression of frostbite over a period of 96 hours.
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Frostbite begins with cold-induced cell death and tissue ischemia, and can lead to thrombosis and eventual necrosis and gangrene. The key interventions for frostbite are rapid rewarming using water immersion, sterile wound care, and orthopedic consultation.
To see more cases like this, visit Figure 1.