Image of the Week: Headache, Nausea, and Skin Discoloration - Clinical Advisor

Image of the Week: Headache, Nausea, and Skin Discoloration

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A 50-year-old man presents to the emergency department with a severe headache, nausea, and a 3-month history of diffuse gray-blue discoloration of the skin. Physical examination reveals a protuberant abdomen with a palpable liver edge that lies 4 cm below the right costal margin. Gray-blue hyperpigmentation of the face and neck is noted. Imaging demonstrates the findings seen here.

Which molecule is responsible for this patient’s skin discoloration?

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