Generic Name and Formulations:
Quinupristin/dalfopristin 500mg per vial (as 150mg quinupristin and 350mg dalfopristin); pwd for IV infusion after reconstitution; preservative-free.
Indications for SYNERCID:
Treatment of complicated skin and skin structure infections due to S. aureus (methicillin-susceptible) or S. pyogenes.
Give by IV infusion over 60mins. ≥16yrs: 7.5mg/kg every 12hrs for at least 7 days.
<16yrs: not established; doses of 7.5 mg/kg every 8hrs or 12hrs have been used in a limited number of children under emergency-use conditions (see full labeling).
Hepatic insufficiency. Pregnancy. Nursing mothers.
Avoid concomitant drugs known to prolong the QT interval. Potentiates CYP3A4 substrates (eg, midazolam, nifedipine, cisapride, carbamazepine, vinca alkaloids, taxanes, steroids, NNRTIs, protease inhibitors, statins); monitor esp. those with narrow therapeutic window (eg, cyclosporine, tacrolimus). May affect digoxin.
Inj site reactions, arthralgia, myalgia, GI upset, thrombophlebitis, rash, headache, pruritus; C. difficile-associated diarrhea.