Onset of Musculoskeletal Adverse Events Varies Between Statins
Significantly faster onset with atorvastatin, rosuvastatin vs simvastatin during monotherapy.
Diagnosis & Disease Information
FDA: Cases of Rare Gangrene of Genital Area Tied to Diabetes Drug Class
The infection developed within several months of the patients starting SGLT2 therapy and the drug was discontinued in most cases. All patients required surgery and there was 1 reported death.
FDA Rejects Treatment for Uterine Fibroids Based on Safety Concerns
The NDA included data from two Phase 3 clinical trials (VENUS I and VENUS II), all four Phase 3 European Union registration studies, and real-world data of >700,000 women with uterine fibroids across 80 countries.
Long-Term PPI Use Linked to Pneumonia Risk in Older Adults
Rate of incident pneumonia increased in second year after initiating treatment with proton pump inhibitors.
Antidepressants and Bleeding Risk: What’s the Link?
Results showed an increased risk of bleeding with SRIs by 1.16-2.36 times with an even higher 3.17- to 10.9-fold risk with concomitant NSAIDs.
Stat Consult: Cleft Lip and Palate
Cleft lip and palate is defined as congenital malformation of the upper lip and/or oral cavity disrupting normal facial structure and oromotor function.
Heat-Stable Carbetocin Safe Alternative to Oxytocin for Postpartum Hemorrhage Prevention
Heat-stable carbetocin — an analog of oxytocin — was found to be noninferior to oxytocin in preventing hemorrhage associated with vaginal birth and may be beneficial in low- and middle-income countries.
Congenital Anomalies Not Linked to Metformin Use After First Trimester
Metformin use during the first trimester of pregnancy is not correlated with an increased risk of congenital anomalies.
Efavirenz Does Not Increase Depression, Suicidal Ideation in HIV-Infected
No increased risk of depression or suicidal ideation among persons living with HIV in Uganda.
Long-Term Antidepressant Use Linked to Weight Gain
The broad use of antidepressants among the general population may be linked to weight gain.
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