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Injection for opioid-induced constipation

Product: Relistor Company: Wyeth  Pharmacologic class: Opioid antagonist (peripheral) Active ingredient: Methylnaltrexone bromide 12 mg/0.6 mL; solution for subcutaneous (SC) injection Indication: Opioid-induced constipation Pharmacology: The use of opioid analgesics can lead to constipation due to their effect on intestinal smooth muscle and their interference with the bowel’s normal elimination function. Methylnaltrexone bro-mide is a…

Weight gain raises CKD risk even in lean folks

A study to be published in the September issue of Journal of the American Society of Nephrology suggests that weight gain, even an amount that does not propel a person into the overweight range, still increases the risk for chronic kidney disease (CKD)—a disease already prevalent enough to be considered a major public-health issue by…

Race-specific hypertension treatment

An obese 48-year-old African American woman was sent from the emergency department for follow-up of newly diagnosed asymptomatic hypertension (BP 226/130 mm Hg). She was started on lisinopril/hydrochlorothiazide (Zestoretic) 40/25 mg daily and clonidine 0.2 mg b.i.d. The patient has Wolff-Parkinson-White syndrome and…

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