Benzodiazepine Use in Early Pregnancy Linked to Spontaneous Abortion
According to the results of a recently published nested case-control study, exposure to any benzodiazepine in early pregnancy may increase the risk of spontaneous abortion (SA).
Obstetrics and Gynecology
Relugolix Combination Therapy Effective in Phase 3 Uterine Fibroids Trial
A phase 3 study evaluating the safety and efficacy of relugolix (Myovant Sciences), an investigational oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in combination with estradiol 1.0mg and norethindrone 0.5mg in women with uterine fibroids, met its primary endpoint.
Oral Contraceptive Pill May Protect Against ACL Tears
Risk for acute cruciate ligament reconstruction reduced while on OCP, especially for 15- to 19-year-olds.
Radiotherapy Tied to Lower Recurrence of Early, Hormone-Driven Breast Cancer
Antihormone treatment also recommended in conjunction with radiotherapy.
Rare Variants Identified in DENND1A Gene in PCOS
Variants are associated with reproductive and metabolic traits in PCOS families.
USPSTF Urges Asymptomatic Bacteriuria Screen in Pregnancy
No evidence seen for benefits of screening nonpregnant women or men for asymptomatic bacteriuria.
Metformin May Cut Risk for Prematurity, Miscarriage in PCOS
But no significant differences seen in gestational DM risk between metformin users, nonusers
FDA Orders Manufacturers to Stop Selling Surgical Mesh for Transvaginal Repair of Pelvic Organ Prolapse
Manufacturers of surgical mesh products indicated for the transvaginal repair of pelvic organ prolapse (POP) have been ordered by the Food and Drug Administration (FDA) to stop selling and distributing these devices.
Review Links Adverse Events to Use of Herbal Meds in Pregnancy
Increased odds of preterm birth with almond oil; oral raspberry leaf linked to cesarean delivery.
Genetic Testing Underused in Breast, Ovarian Cancer
Pathogenic variants identified in 7.8% of patients with breast cancer, 14.5% with ovarian cancer.
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