What Are the Most Common Hypothyroidism Comorbidities?
Researchers analyzed a hypothyroidism comorbidity network for positive and negative associations with other chronic conditions.
Schizophrenia
Treatment-Resistant Schizophrenia: Effects of Smoking on Clozapine and Health
Smoking increases the metabolism of clonidine through the CYP1A2, which may require the dose to be doubled to have the same plasma concentration as a non-smoker.
Schizophrenia Practice Guidelines Mostly Recommend Long-Acting Injectable Antipsychotics During First Episode
Recommendations for pharmacotherapy with antipsychotics as both acute and maintenance treatment of schizophrenia were made following a systematic literature review of current clinical practice guidelines.
Olanzapine, Samidorphan Dual Therapy Well Tolerated in Schizophrenia
Researchers report on the 52-week extension of the ENLIGHTEN-2 study that assessed the long-term safety and efficacy of treatment schizophrenia with olanzapine and samidorphan.
Weight Gain During Mental Health Treatment May Negatively Impact Hopefulness, Medication Attitudes, and Depression
Researchers conducted a study to investigate the bidirectional nature of the relationship between obesity and depression.
Extrapyramidal Symptoms in Schizophrenia Associated With Higher Healthcare Costs
Extrapyramidal symptoms that developed in patients with schizophrenia after initiation of treatment with atypical antipsychotic agents were associated with increased healthcare resources and costs.
Weight Gain, Treatment Interruptions Reported With Second-Generation Antipsychotics for Schizophrenia, Bipolar 1 Disorder
Research was conducted to assess the impact of initiation of treatment with second-generation antipsychotics and treatment interruptions on weight gain in patients with schizophrenia and bipolar 1 disorder.
Suicide Rate Up for Schizophrenia Spectrum Disorders
Overall, 1.71% of individuals with a first lifetime diagnosis of schizophrenia, schizoaffective disorder, or psychotic disorder not otherwise specified die by suicide.
Relapse More Likely With Antipsychotic Switch in Schizophrenia, Bipolar Disorder, or MDD
Patients with schizophrenia or a mood disorder who switched antipsychotic treatment had an increased likelihood for relapse, healthcare resource utilization, and extrapyramidal symptoms.
Some Nutritional Supplements May Aid Mental Health Conditions
Nutrient supplements had good safety profiles, no known contraindications with psychiatric medications.
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