Treatments

Olaparib Treatment May Improve Health-Related Quality of Life in Germline <I>BRCA1/2</I>-Mutated Ovarian Cancer

Olaparib Treatment May Improve Health-Related Quality of Life in Germline BRCA1/2-Mutated Ovarian Cancer

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Olaparib, may help to improve duration of good quality of life and quality-adjusted progression-free survival in germline BRCA1/2-mutated ovarian cancer.

Fostamatinib Seems Effective for Immune Thrombocytopenia

Fostamatinib Seems Effective for Immune Thrombocytopenia

Overall response of platelet count 50,000/L seen in 43% of patients.

TMS Device Cleared to Treat Obsessive Compulsive Disorder

TMS Device Cleared to Treat Obsessive Compulsive Disorder

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Transcranial magnetic stimulation (TMS) uses magnetic fields to stimulate nerve cells in the brain.

Ibalizumab Active in Multidrug Resistant HIV-1 Infection

Ibalizumab Active in Multidrug Resistant HIV-1 Infection

Lower degree of susceptibility to ibalizumab for 9 of 10 patients with virology failure, rebound.

Antibiotics Often Unnecessary for Sacral Pressure Ulcers Complicated by Osteomyelitis

Antibiotics Often Unnecessary for Sacral Pressure Ulcers Complicated by Osteomyelitis

A systematic literature review, published in Clinical Infectious Diseases, found no evidence supporting a benefit to antibacterial therapy for osteomyelitis in patients with stage IV sacral pressure ulcers.

Daily BCX7353 Cuts Rate of Hereditary Angioedema Attacks

Daily BCX7353 Cuts Rate of Hereditary Angioedema Attacks

Oral administration of BCX7353 at dose of 125 mg results in lower rate of attacks vs placebo.

Rifampin Similar to Isoniazid for Preventing Active Tuberculosis

Rifampin Similar to Isoniazid for Preventing Active Tuberculosis

Rifampin has significantly higher rate of treatment completion, fewer drug-related adverse events.

Gut Microbiota Alterations May Not Be Enough to Relieve Irritable Bowel Syndrome

Gut Microbiota Alterations May Not Be Enough to Relieve Irritable Bowel Syndrome

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As fecal microbiota transplantation has been found to be effective in treating a number of gastrointestinal diseases, such as Clostridium difficile infection, researchers are now assessing whether it may also be effective for patients with irritable bowel syndrome.

Nemolizumab Effective for Moderate, Severe Atopic Dermatitis Inadequately Controlled With Topical Therapy

Nemolizumab Effective for Moderate, Severe Atopic Dermatitis Inadequately Controlled With Topical Therapy

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For patients with moderate to severe atopic dermatitis inadequately controlled with topical therapies, the anti-IL-31 receptor A humanized monoclonal antibody nemolizumab may provide benefit.

Guidelines for ART Updated for Those With or at Risk for HIV

Guidelines for ART Updated for Those With or at Risk for HIV

ART recommended for almost all HIV-infected; should be initiated as soon as possible post diagnosis.

Basal Insulin Analogs vs NPH Insulin to Reduce Hypoglycemia-Linked ED Visits in T2D

Basal Insulin Analogs vs NPH Insulin to Reduce Hypoglycemia-Linked ED Visits in T2D

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Compared with human neutral protamine Hagedorn insulin, basal insulin analogs do not reduce risk of hypoglycemia-linked ED visits or hospital admissions in T2D.

L-Glutamine Oral Therapy Reduces Sickle Cell-Related Pain Better Than Placebo

L-Glutamine Oral Therapy Reduces Sickle Cell-Related Pain Better Than Placebo

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L-Glutamine oral treatment with or without hydroxyurea reduces pain crises better than placebo in individuals with sickle cell disease.

Single High-Dose Liposomal Amphotericin B Effectively Treats HIV-Associated Cryptococcal Meningitis

Single High-Dose Liposomal Amphotericin B Effectively Treats HIV-Associated Cryptococcal Meningitis

Single high-dose liposomal amphotericin B (L-AmB) is non-inferior to daily dosed L-AmB at the standard dose in treatment of fungal clearance in HIV-associated cryptococcal meningitis.

Is New Surveillance Monitoring Required for Enterococcal Oxazolidinone Resistance?

Is New Surveillance Monitoring Required for Enterococcal Oxazolidinone Resistance?

A study was conducted to evaluate the oxazolidinone resistance mechanisms of enterococci bacteria.

Chemotherapy With Bevacizumab May Improve Some Ovarian Cancer Outcomes, Worsen Others

Chemotherapy With Bevacizumab May Improve Some Ovarian Cancer Outcomes, Worsen Others

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First-line chemotherapy in combination with bevacizumab, compared with chemotherapy alone, may benefit patients with ovarian cancer and elevated neutrophil-to-lymphocyte ratios.

Avastin Plus ChemoTx Approved for Advanced Ovarian Cancer After Resection

Avastin Plus ChemoTx Approved for Advanced Ovarian Cancer After Resection

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Study patients who received Avastin plus chemotherapy followed by Avastin alone, had a greater median PFS vs patients who received chemotherapy alone (18.2 months vs 12 months; hazard ratio [HR] 0.62, 95% CI, 0.52-0.75; P<.0001).

FDA: Zephyr Endobronchial Valve Approved for Severe Emphysema

FDA: Zephyr Endobronchial Valve Approved for Severe Emphysema

Valve has been approved after review of data from trial involving 190 patients with emphysema

Mirvetuximab Gets Fast Track Status for Platinum-Resistant Ovarian Cancer

Mirvetuximab Gets Fast Track Status for Platinum-Resistant Ovarian Cancer

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Mirvetuximuab soravtansine uses a humanized FRα-binding antibody to target antibody-drug conjugates specifically to FRα-expressing cancer cells and a potent anti-tumor agent, DM4, to kill the targeted cancer cells.

Weighing the Risks of Deep Brain Stimulation

Weighing the Risks of Deep Brain Stimulation

DBS has been known to generate other movement-related disorders such as dyskinesias, blepharospasm, and hypokinesia.

Psoriasis Treatment With Biologics Often Requires Multiple Courses, Treatment Changes

Psoriasis Treatment With Biologics Often Requires Multiple Courses, Treatment Changes

The final analysis set comprised biologic-naïve individuals — individuals who had filled an initial prescription for etanercept, infliximab, adalimumab, or ustekinumab after 2 years without using any biologic agent during the study period.

Diagnosis, Treatments Affected by Amyloid Results in Dementia, Nondementia Patients

Diagnosis, Treatments Affected by Amyloid Results in Dementia, Nondementia Patients

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In patients with and without dementia, amyloid-positive and negative results were significantly linked to diagnoses and treatment changes.

Mortality Risk Compared Among Men Receiving Drug Therapy for BPH/LUTS

Mortality Risk Compared Among Men Receiving Drug Therapy for BPH/LUTS

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Researchers conducted a retrospective matched cohort study to compare the risk of death among BPH patients treated with 5ARIs, as monotherapy or in combination with alpha-blockers, and those treated with alpha-blockers alone.

A History of Race and the Emerging Role of Genetics in Primary Care

A History of Race and the Emerging Role of Genetics in Primary Care

In 2003, the Human Genome Project became the culmination of the history of genetics research, allowing us to understand the role of genetics in human health and disease. As part of The Clinical Advisor's 20th Anniversary, this article explores the influence of race and genetics in clinical practice.

Sofosbuvir Improves Renal Safety in Patients With Chronic Hepatitis C

Sofosbuvir Improves Renal Safety in Patients With Chronic Hepatitis C

Patients with mild, moderate renal impairment showed improvement in renal biomarkers over one year

Microneedling Plus Bleomycin Spraying Superior for Plantar Wart Treatment

Microneedling Plus Bleomycin Spraying Superior for Plantar Wart Treatment

Microneedling combined with bleomycin was associated with higher clearance rates and was less painful than the use of intralesional bleomycin injections.

Budesonide-formoterol as needed superior to terbutaline in mild asthma: The SYGMA trial

In patients with mild asthma, use of the inhaled combined corticosteroid and beta agonist budesonide-formoterol as needed was superior to terbutaline as needed with respect to electronically recorded weeks of well-controlled asthma.

Patients with Frontal Chronic Headaches May Benefit from Endoscopic Decompression Surgery

Patients with Frontal Chronic Headaches May Benefit from Endoscopic Decompression Surgery

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Oral medication, botulinum toxin type A injections, and endoscopic decompression surgery were all compared in the treatment of patients with frontal secondary headaches due to STN and SON configuration.

Pharmaceutical Marketing Associated With Increased Opioid Prescription Rates

Pharmaceutical Marketing Associated With Increased Opioid Prescription Rates

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Payments correlated with prescribing opioids in 2014 may have influenced the increased prescription rates of 2015.

Psychological Interventions Beneficial for Chronic Pain in Older Adults

Psychological Interventions Beneficial for Chronic Pain in Older Adults

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Researchers found a positive but weak correlation between psychological interventions and chronic pain treatment in older adults.

Many Oncologists Discuss, Recommend Medical Marijuana

Many Oncologists Discuss, Recommend Medical Marijuana

But majority of oncologists don't feel knowledgeable enough to make these recommendations

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