Vaccine Information Center Archive

Pregnant Women Commonly Refuse Vaccines

Providers believe stressing fetal protection is most effective strategy against refusal.

Does Gestational Age at Birth Impact Seizure Risk Following Receipt of Measles Vaccine?

The study utilized the Vaccine Safety Datalink and included children who received the first dose of a measles-containing vaccine between 12 and 23 months old during the study period of January 1, 2003 to September 20, 2015.

Herpes Zoster Recombinant Vaccine Seems Most Effective

However, adjuvant recombinant subunit vaccine tied to more injection site adverse events.

Influenza Vaccines May Protect Against Lab-Confirmed Influenza-Linked Hospitalization During Pregnancy

For women who are pregnant, influenza vaccines may moderately protect against laboratory-confirmed influenza-associated hospitalization.

Tdap Vaccine Can Be Administered as a Decennial Booster Dose

A second dose of Tdap, a reduced-antigen-content tetanus-diphtheria-acellular pertussis vaccine, 9 years after initial vaccination was well tolerated and immunogenic.

Prior-Season Vaccination Not Associated With Flu Shot Effectiveness

Prior-season vaccination is not associated with reduced vaccine effectiveness among children aged 2 to 17 years.

Health Officers Express Concerns About Vaccine Exemptions

Health officers and immunization staff reported concerns including an increase in medical exemptions.

Influenza Vaccination Rates Vary as Clinic Day Progress

Research results indicated vaccination rates declined as clinic day progressed and that active choice intervention was linked with increased vaccinations.

Gap Found in Pneumoccal Vaccine Recommendations Among Primary Care Clinicians

While primary care physicians overwhelmingly recommend pneumococcal vaccines, there is a gap in their knowledge of how to implement related vaccine recommendations.

Postnatal Education Increases Pain Relief Interventions at Vaccinations

In-hospital postnatal education about infant pain management at vaccinations leads to more frequent use of pain relief interventions

Third Trimester Immunization With Tdap Vaccine Optimal for Pertussis Toxin Antibody Concentrations in Newborns

Immunization with Tdap vaccine during the third trimester of pregnancy resulted in higher concentrations of pertussis toxin antibodies in newborns.

Pneumococcal H Influenzae Protein D Conjugate Vaccine Effective in Children

The burden of childhood and infant pneumonia can be effectively reduced through the use of the pneumococcal Haemophilus influenzae protein D conjugate vaccine.

Gardasil 9 Approved for Use in Women and Men 27 Through 45 Years Old

The approval of the expanded age range was based on data from a clinical trial which evaluated the efficacy of Gardasil (quadrivalent human papillomavirus recombinant vaccine) in 3253 women 27-45 years of age with a median duration of follow-up of 3.5 years post-dose 3.

More Than 14 Million Preteens Need to Receive HPV Vaccine

14 million need to receive two doses of vaccine to reach goal of 80% vaccination by 2026.

Variations in Influenza Vaccination Coverage Among Healthcare Employees Reported

Wide variations in influenza vaccine coverage have been noted across healthcare personnel based on occupation and worksite.

Active Choice Intervention Effective in Increasing Influenza Vaccination Rates at Primary Care Practices

Influenza vaccination rates decline as the clinic day progresses.

Monovalent Acellular Pertussis Vaccine Safe and Effective for Neonates With Mothers Unvaccinated for Tdap

The monovalent acellular pertussis vaccine may be beneficial to neonates whose mothers did not receive Tdap vaccine during pregnancy.

HPV Vaccination Decreases High-Grade Cervical Lesions in Women

From 2008 to 2015, both cervical intraepithelial neoplasia grades 2, 3 and adenocarcinoma in situ rates and cervical cancer screening declined in women age 18 to 24 years.

High Population Immunity Aids in Global Elimination of Sabin-2 Poliovirus

High population immunity is an indicator of the decline in serotype 2 Sabin vaccine poliovirus after serotype 2 oral poliovirus vaccine withdrawal.

Prenatal Tdap Vaccination Not Associated With an Increased Risk of Autism

No association was observed between prenatal vaccination of Tdap vaccination and an increased risk of autism spectrum disorder risk in children.

AAP Updates Recommendations for Pediatric Flu Vaccination

All children age 6 months and older, including teens, advised to undergo annual immunization.

China Withholding H7N9 Bird Flu Virus Samples From US

Specimens of the rapidly evolving virus are needed to develop vaccines and treatments.

Serogroup B Meningococcal Vaccine, Disease Knowledge Gaps Apparent in Primary Care

Due to a gap in knowledge regarding serogroup B meningococcal (MenB) disease and vaccination, the majority of clinicians are not discussing MenB vaccines with their adolescent patients during routine visits.

CDC: Updated Influenza Vaccination Recommendations for 2018-2019

In general, routine annual vaccination is recommended for all patients ≥6 months of age who have no contraindications.

Novel Malaria Vaccine Shows Activity Only at Peak Titers

A malaria transmission-blocking vaccine, Pfs25H-EPA in Alhydrogel®, was well tolerated and safe and induced significant blockage of parasite transmission, but this activity was only seen at peak titers after 4 vaccine doses.

How to Tell Your Anti-Vaccine Patients the Truth About Vaccines

What's the best way to tell your anti-vaccine patients the truth about vaccines?

Parental Influences on HPV Vaccination Among Low-Income Hispanic Adolescent Girls

Researchers sought to identify parental predictors of HIV vaccination in low-income adolescent Hispanic girls.

Safety and Immunogenicity of Tdap Vaccine Immunization During Pregnancy

Immunization with Tdap vaccine during pregnancy results in higher levels of antibodies early in infancy but lower levels after the primary vaccine series.

Vaccinations Begin in Congo Ebola Outbreak

First to be vaccinated will be health workers, contacts of confirmed Ebola patients.

Combined Meningococcal-Tdap Vaccine May Increase Adolescent Vaccination Coverage

For adolescents and young adults, the co-administration of quadrivalent meningococcal conjugate vaccine with incorporated tetanus toxoid with diphtheria-tetanus-acellular pertussis vaccine is noninferior to isolated vaccination and does not compromise immunity.

Rotavirus Vaccination Linked to Decrease in Hospitalizations

A significant decline in rotavirus disease-associated hospitalization, emergency department visits, and physician office visits was demonstrated in children younger than 5 years following implementation of the rotavirus vaccine.

Inactivated Influenza Vaccine Preferred for Nursing Mothers

Women receiving the inactivated influenza vaccine demonstrated superior antibody response compared with those receiving the live attenuated influenza vaccine.

HPV Vaccine Eliminates Advanced Skin Cancer in 97-Year-Old

Less than a year following the initial direct-to-tumor vaccine injection, all treated tumors disappeared.

HPV Vaccine Failure Rates May Be Higher in Women, Girls With HIV

Vaccinated women and girls living with HIV may be at greater risk for HPV vaccine failure compared with women and girls without HIV.

Lack of Vaccination in High-Exempt Areas Linked to Medical Distrust

Exemption from vaccination is common in Arizona school districts due to lack of trust in medical establishments.

Public Health Vaccine Opposition Growing in the United States

Inverse association identified between NME rate and MMR vaccine coverage of kindergarteners.

Otitis Media-Related Ambulatory Visits Declined After Pneumococcal Conjugate Vaccine

The administration of PCV7 and PCV13 reduced the number of ambulatory visits for otitis media in pediatric patients.

Universal Purchase Programs in the United States May Not Effectively Increase Vaccination Rates

Using state- and individual-level data from the 1995-2014 National Immunization Survey, the effect of a state's Universal Purchase adoption on vaccination rates was estimated.

New AAP Policy on Patient Dismissal for Vaccine Refusal May "Erode Solidarity" Among Pediatricians

Others have argued that dismissal is ethically problematic because it can deprive children of comprehensive pediatric care and undermine public health.

Poor Adherence Contributes to Inadequate Uptake of Multidose Hepatitis Vaccine Schedules

Adherence and completion to multidose vaccine schedules for hepatitis A, B, and A-B are low, thereby rendering vaccination ineffective.

Demographic Insights Into Hepatitis Vaccination Practices

From 2007 to 2015, the majority of initial hepatitis A, B, and A/B vaccinations were administered by primary care providers.

CDC Surveillance Information for the 2017-2018 Influenza Season in the United States

The 2017-2018 influenza season in the United States (October 1, 2017-May 19, 2018) was a high-severity season.

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

Systemic shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis.

No Association Between Rotavirus Vaccination and Intussusception in New Study

The risk of intussusception within 1 to 7 days and 8 to 21 days after rotavirus vaccination was assessed in infants age 28 to 245 days.

Vaccination of Auto-HSCT Patients May Reduce the Risk of Herpes Zoster Diagnosis

Early vaccination of autologous hemopoietic stem-cell transplant (auto-HSCT) recipients during the peri-transplant period can be effective for the prevention of infections such as herpes zoster.

Varicella Zoster Vaccine Effective for Hematopoietic Stem Cell Transplant Recipients

In a phase 3 clinical trial, early vaccination effectively prevented herpes zoster in auto-HSCT recipients.

CDC: Administration Errors Reported With New Shingles Vaccine

Between October 20, 2017 and February 20, 2018, the Vaccine Adverse Event Reporting System (VAERS) received 155 reports involving RZV, with 13 (8%) involving an administrative error.

Is Current Hib Vaccine Effectiveness Decreasing in Children?

The hexavalent DTPa-HBV-IPV/Hib vaccine may not affect Hib vaccine efficacy.

CDC: Get Vaccinated for Measles Before Traveling

The CDC recommends 2 doses of the MMR vaccine, which provides 97% protection against measles, prior to international travel.

Robust Immune Responses for Herpes Zoster Subunit Vaccine

Humoral response seen for 97.8% of HZ/su vaccine recipients vs 2% of placebo

Good Evidence That HPV Vaccines Protect Against Cervical Precancer

High-certainty evidence for protection in adolescent girls and young women aged 15 to 26 years

ACOG: Updated Recommendations for Influenza Vaccination During Pregnancy

This updated Committee Opinion includes more recent data on the safety and efficacy of influenza vaccination during pregnancy, as well as recommendations for treatment and postexposure chemoprophylaxis.

Maternal TDF not effective in reducing hepatitis B transmission

TDF did not reduce mother-to-child HBV transmission in mothers taking hepatitis B Ig and HBV vaccine.

Clinician HPV interventions facilitate adolescent HPV vaccination

Clinicians using communication training and fact sheets to inform adolescents about HPV, significantly increased vaccination initiation and completion rates among their patients.

Newer HIV testing options underused in Black MSM and transgender women

Increasing awareness of and access to newer HIV testing options such as free or reduced price on home and self-tests and couples HIV testing and counseling can facilitate increased levels of consistent testing among young, Black MSM, and transgender women.

CDC: Influenza vaccine 25% effective against H3N2 in 2017-2018

The 2017 to 2018 influenza vaccine reduces the chance of getting the disease by about 33%, but is only 25% effective against H3N2, otherwise known as influenza A.

ACIP releases 2018 recommended immunization schedule for adults

The Advisory Committee on Immunization Practices updated its immunization recommendations for adults.

2018 Immunization schedule for children, adolescents: ACIP recommendations

The updates contain new or revised ACIP recommendations for poliovirus, influenza, and measles, mumps, and rubella vaccines, as well as a clarification of the recommendations for rotavirus and pneumococcal vaccines.

Herpes zoster subunit vaccine more effective, less expensive than live attenuated herpes zoster vaccine

The adjuvanted herpes zoster subunit vaccine is more effective and less expensive than the live attenuated herpes zoster vaccine at all ages.

Provider-demanded flu testing less likely in elderly patients

Younger adults are more likely to have provider-ordered flu testing than older adults.

Multiple flu vaccinations may prevent death, serious infection

Intensive care and death were greatly prevented in patients who were annually vaccinated.

Flu vaccine safe for individuals with egg allergy

Inactivated and live attenuated flu vaccines can be safely administered to people with egg allergies.

Healthcare system fires 50 employees for refusing influenza vaccination

A Minnesota-based hospital chain fires about 50 employees for refusal to receive the influenza vaccine.

FDA approves Heplisav-B vaccine for hepatitis B treatment

The Food and Drug Administration (FDA) has approved Heplisav-B for the prevention of infection caused by all known subtypes of hepatitis B virus.

Reduced effectiveness of last season's flu vaccine traced to mutation in chicken eggs

New virus mutations make antibody binding difficult as mismatches in vaccines and viruses emerge.

Proposed pneumonia vaccine provides universal pneumococcal disease prevention

A pneumonia vaccine under development provides the most comprehensive coverage to date and alleviates antimicrobial concerns.

Vaccination coverage remains above 90% for infants

Infants aged 19-35 months had vaccination rates above 90%.

CDC committee recommends new shingles vaccine

CDC voted for Shingrix over Zostavax as herpes zoster vaccine of choice

Module created to improve adult vaccination rates

The AMA STEPS Forward module helps health care professionals save time by creating a team-based approach for an adult immunization program.

No evidence that the influenza vaccine causes VTE

In the 1 to 10 days after flu vaccine administration, there was no increased risk for VTE.

Positive mood associated with enhanced responses to influenza vaccination

Greater positive mood significantly predicted greater antibody responses to the influenza vaccination.

Tdap vaccination during pregnancy protects infants from pertussis

With a continuing resurgence in pertussis, efforts should focus on maximizing Tdap uptake among pregnant women.

Half of adults with work-related asthma receive pneumococcal vaccination

The researchers found that 42% of the estimated 12 million ever-employed adults with current asthma had received a pneumococcal vaccine.

CDC releases updated influenza vaccine recommendations for 2017-2018

The Advisory Committee on Immunization Practices has released the guidelines for the 2017-2018 season.

AAP: Hepatitis B vaccine should be given within first 24 hours of life

The American Academy of Pediatrics recommends that the first dose of the hepatitis B vaccine should be given within the first 24 hours of life.

Anti-vaccine information during pregnancy could delay infant immunization

Information about vaccines received during pregnancy could influence infant immunization.

Live attenuated influenza vaccine ineffective in children during 2015-2016 season

The live attenuated vaccine was ineffective among children between 2 and 17 years of age during the 2015-2016 season.

Previous maternal influenza vaccine does not weaken newborn benefit

Researchers found that in a cohort of pregnant women, receipt of influenza vaccine the previous year predicts higher baseline antibody titers and decreased peak antibody responses against all influenza strains.

12.9 million infants worldwide not vaccinated in 2016: A WHO report

Nearly 1 in 10 infants did not receive any vaccinations in 2016, according to the World Health Organization.

CDC urges measles vaccine for European travelers

Most measles cases in the United States are the result of international travel.

Clinician communication affects parental decision-making with pediatric influenza vaccine

About half of patients accepted influenza vaccination for their child if the clinician used a presumptive vs participatory initiation format.

Injectable antiretroviral therapy for as HIV effective as oral medications

The investigators found that after 32 weeks, HIV remained suppressed in 91% percent of those taking the drugs orally, 94% of those receiving monthly injections, and 95% of patients receiving injections every two months.

CDC: 101 influenza deaths in children reported for 2016-17

A total of 101 influenza-related deaths occurred among children throughout the 2016-17 flu season.

Hepatitis B vaccine reduces risk of non-Hodgkin lymphoma in adolescents

The universal vaccination against hepatitis B virus infection prevented non-Hodgkin lymphoma in adolescents.

Maternal antibodies inhibit antigenic responses to vaccines in infants

Vaccines given shortly after birth demonstrated a strong inhibitory response to maternal antibodies.

Updated meningococcal vaccine guidelines reflect more dosing options

The Advisory Committee on Immunization Practices released updated guidelines to include recommendations for the 3-dose formulation of serogroup B meningococcal vaccine.

CDC finalizes cholera vaccine recommendation for international travelers

Cholera, an acute, diarrheal illness, is spread by drinking water or eating food that is contaminated with cholera bacteria.

HPV vaccine effective against genital warts in 2 doses

The researchers found that 2 doses of the HPV vaccine were just as protective as 3 doses.

HPV vaccine substantially reduces oral HPV risk

The data suggest that the vaccine may be reducing the prevalence of those infections by as high as 100%.

Almost half of men and women under 60 in the US infected with HPV

However, the HPV vaccine has the potential to reverse the epidemic and prevent thousands of cancers in the United States each year.

2017 Adult immunization schedule released by the CDC

The ACIP has released the 2017 recommended immunization schedule for adults.

2017 immunization schedule for children and adolescents released by CDC

The schedule includes new or revised recommendations for several vaccines for children and adolescents.

CDC: Influenza vaccine rate low this season

Forty percent of people have reported receiving the flu vaccine thus far, including 37% of children.

CDC approves HPV vaccine in 2 doses for preteens

Children younger than 15 may be given 2 HPV vaccine doses instead of 3, and the shots should be spaced at least 6 months apart.

Addressing parental vaccine concerns: AAP provides guidance for clinicians

The AAP has released a report to help clinicians address the concerns of parents who are hesitant about their children's vaccination.

Mumps outbreak controlled by third dose of MMR vaccine

A third dose of the MMR vaccine should be administered in cases of a mumps outbreak.

Concomitant vaccine administration may increase febrile seizure risk

Children who receive the influenza vaccine at the same time as PCV or a DTaP-containing vaccine have an increased risk for febrile seizure.

Predicting viral mutations may improve flu vaccine efficacy

Natural viral mutations ensure that the seasonal flu vaccine must be updated on a yearly basis.

Delayed immunizations, breastfeeding over age 1 may increase risk for caries

Researchers identify new risk factors for caries in young children.

Vaccines administered in the morning may be more effective

Vaccines administered between 9 and 11 AM showed a significant increase in patients' antibody concentration

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