WHO named vaccine hesitancy a top 10 threat to global health in 2019. Hysteresis may describe persistent skepticism.
Between 2016 and 2017, the mean paid childbearing leave for faculty physicians at 12 top United States medical schools was just 8.6 weeks.
Despite research suggesting that there may be increased cardiovascular risk from off-label prescription testosterone use, usage in men with coronary artery disease remains higher than in men without coronary artery disease.
The investigational drug is currently in Phase 1 development, with completion expected in the second quarter of 2019.
The number of enteric infection symptom reports was found to decrease with age, although older adults tend to have more severe illness and require hospitalization.
For patients with both physical and mental health-related long-term conditions, missing healthcare appointments is associated with an increased risk of multimorbidity.
The Company has already completed a Phase 1 trial of this synthetic glucagon-like peptide (GLP-2) analog.
Chronic infection with Giardia was associated with prolonged alterations in duodenal mucosa lymphocytes.
The prevalence of anogenital warts has decreased, with significant declines observed in specific populations.
A task force of the International Association for the Study of Pain proposes a classification of chronic pain as either chronic primary or chronic secondary pain, when chronic pain represents the major complaint and when chronic pain is secondary to a chronic disorder, respectively.
Data on adherence to the 2013 ACA/AHA cholesterol guidelines suggest significant underuse of appropriate-intensity statin therapy; however, data for statin use in primary prevention have been limited.
Eliminating routine oral opioid prescription following cesarean delivery may reduce opioid consumption without jeopardizing pain control or patient satisfaction.
The combined use of mometasone furoate and formoterol in adults and adolescents with persistent asthma may not increase asthma-related adverse events and may reduce the risk of worsening asthma outcomes.
Fatigue and depressive symptoms had a negative effect on work stability in patients with ankylosing spondylitis.
Tuberculosis screening results may differ depending on blood draw methods.
A review of the 2016 American Heart Association and American College of Cardiology guidelines for management and diagnosis of peripheral arterial disease.
Pulsed ultrasound treatment may represent an effective option for the treatment of stable rib fractures.
Releasing report cards on Fridays may increase the rate of child physical abuse on the following Saturday.
Researchers evaluated the efficacy and safety of anakinra for the treatment of acute gout flares.
The Psoriatic Arthritis Impact of Disease questionnaire was endorsed as a core outcome measure for psoriatic arthritis-specific health-related quality of life.
Children with croup who were given glucocorticoids had reduced symptoms at 2 through 24 hours.
Short-term pasteurization of breast milk may reduce the incidence of postnatally acquired cytomegalovirus infection through breast milk.
The need for effective osteoporosis screening tools and treatment strategies is high, as the current methods have a low sensitivity for determining postmenopausal women at risk for a major osteoporotic fracture.
Patients with Crohn disease were enrolled in a comparative cohort study that analyzed the outcomes of reference product infliximab vs biosimilar treatment.
Weighted and combined multi-gene pharmacogenomic testing significantly increased clinical response and remission rates for patients with major depressive disorder.
Minimum inhibitory concentration levels of resistance to either clarithromycin or metronidazole may play a role in Helicobacter pylori therapy outcome.
Regular and prolonged walking was found to be associated with a reduced the risk for low back pain in Koreans age >50.
Adults hospitalized for pneumonia who received an influenza vaccination during their stay were less likely to seroconvert if they had diabetes, bacterial detection, baseline seropositive titers for influenza B, or influenza vaccination in the previous season.
American Headache Society Releases Position Statement on Novel Preventive and Acute Migraine Treatments
The American Headache Society has issued updated guidelines on the use of novel preventive and acute treatments for migraine in adults.
HeartGuide is designed as a wrist watch that uses the oscillometric cuff method, the standard for medical-grade personal blood pressure measurement.
An informational intervention — including weight management and regular self-weighing — can help curb weight gain during the holiday season.
Researchers assessed risk factors for cytomegalovirus antigenemia in pediatric patients.
Although treatment as usual for psychosis is guideline-congruent and well implemented, there appears to be no added value for adjunct cognitive behavioral therapy for social activation, according to the results of a study from the Netherlands.
While evidence-based guidelines exist for the determination of brain death in infants, children, and adults, Nevada is currently the only state to adopt laws that require adherence to these guidelines.
An expert panel assessed 41 diets to come up with their final results, examining the evidence behind each diet's claims, the short-term and long-term weight loss associated with the diet, how easy the diet is to follow, how well each diet conforms to current nutrition standards, and its effect on diabetes and cardiovascular disease prevention.
Racial disparities may be widening within safety-net hospitals for non-HRRP-targeted conditions.
A study was conducted to assess the safety, tolerability, and efficacy of methyl estradiolpropanoate, a topical soft estrogen cosmeceutical for the treatment of estrogen-deficient skin.
Patients with type 2 diabetes treated with liraglutide experience a greater reduction in systolic BP if they have lower baseline continuous glucose monitoring values and higher diastolic BP.
Compared with unscreened individuals, a colonoscopy with normal findings may be linked to lower risk of colorectal cancer deaths for more than 12 years.
Pregnant women presenting with migraine to acute care settings were found to be treated with therapeutic agents ranging from safe and effective medications to others with unclear efficacy and potential teratogenicity.
Decreases in abundance of several taxa may be linked to increased risk for carbapenem-resistant P aeruginosa colonization-acquisition ICU patients.
Implementation of an ultrarestrictive protocol for opioid prescriptions was found to be associated with reductions in the amount of opioids prescribed after abdominal and gynecologic surgery.
Researchers sought to determine if the complementary practice could prevent CIPN in patients receiving adjuvant chemotherapy for breast cancer.
Vitamin D3 may reduce migraine days in patients who experience frequent migraines.
Requip and Requip XL are non-ergot dopamine agonists indicated for the treatment of Parkinson disease.
The omega-3 polyunsaturated fatty acid eicosapentaenoic acid and aspirin were compared alone and in combination against placebo for the prevention of colorectal cancer.
Lynparza, a poly (ADP-ribose) polymerase (PARP) inhibitor is already approved to treat certain breast, epithelial ovarian, fallopian tube or primary peritoneal cancers based on an FDA-approved companion diagnostic.
Inhaling a 25 mg dose of vaporized cannabis with 10 mg of THC produced pronounced drug effects in healthy adults who were infrequent users of cannabis.
The clinical effectiveness of incremental periprocedural antibiotics for patients receiving cardiac implantable electronic devices was examined.
Women who used a self-screening assay for high-risk human papillomavirus had similar test results to those who were screened by a clinician.
New research may help identify new candidate targets and stratify patients eligible for innovative therapies.
IVUS-guided DES implantation resulted in a lower incidence of target-vessel failure at 12 months for patients undergoing PCI.
The ADA published its 2019 Standards of Medical Care in Diabetes, an evidence-based document intended to provide clinicians, patients, and other stakeholders in the diabetes treatment landscape with up-to-date recommendations.
The prevalence of food allergy in US children has increased, including the number of emergency department visits as well as severe allergic reaction responses, reflecting a growing public health concern.
Black women with the most common type of breast cancer had worse clinical outcomes compared with white women, despite receiving similar systemic therapy.
In the Phase 3 JET8 study (N=318), patients underwent a circadian challenge of 8 hours in advance to their usual bedtime.
It's easy for patients to seek out information that backs up their beliefs and dismiss other sources as "fake news."
Elective cesarean delivery may influence the risk of early childhood overweight.
Researchers find that surgical decision making is often driven by factors beyond extent of disease.
Investigators examined whether excessive food allergy testing in patients with atopic dermatitis might lead to food intolerance when certain foods are removed from the diet.
For women with fibromyalgia, comorbid posttraumatic stress disorder may contribute to blunted cardiovascular reactivity to stress.
The transition from the workforce into retirement is always challenging, but for physicians accustomed to working long or odd hours, it can be especially difficult.
Pilot study sought to determine risk of breast cancer among African American women veterans.
Researchers sought to determine how subjective measures of CIPN correlated with objective measures of CIPN.
Primary care consultation patterns for a prespecified set of symptoms may be used to identify patients who later develop a psychotic illness.
Study findings measure quality of life for pregnant patients with breast cancer and reveals the effectiveness of disease-specific assessment tools.
A levonorgestrel 52-mg intrauterine system was found to be safe and effective for pregnancy prevention.
Patients with voriconazole-resistant invasive aspergillosis have a higher mortality rate compared with patients with voriconazole-susceptible infection.
The comorbid presence of central apnea has been identified by multiple researchers as predictive of SUDEP.
Placental malaria has a profound effect on the fetal immune system, and prenatal malaria exposure categories may drive heterogeneity to malaria susceptibility.
No evidence for reduction in risk for late miscarriage or spontaneous preterm birth as a result of screening and treatment for bacterial vaginosis.
Study Finds Cottonseed Oil Better Than Olive Oil at Improving Cholesterol Profiles, Triglyceride Levels
A diet rich in cottonseed oil was found to improve cholesterol and triglyceride levels in healthy men.
Treatment of thyroid disease, severe infections, glucagon prescriptions, and diabetic retinopathy occur more frequently in individuals with type 1 diabetes who are subsequently diagnosed with Addison disease.
Some patients may not be comfortable discontinuing colorectal cancer screening despite minimal benefit associated with the testing.
Zoliflodacin was effective in treating gonococcal urogenital and rectal infections, but less effective in the treatment of pharyngeal gonorrhea.
Internationally, infertility is ranked as the fifth most serious disability among women.
Patients with stable type 2 diabetes may be unnecessarily self-monitoring blood glucose levels despite this practice being recognized as a low-value service.
The immunogenicity generated by 3 experimental Ebola vaccines appears to be long-lasting, as it has persisted for at least 2.5 years.
A simple intradermalanti-Ebola DNA vaccine may generate strong immunogenicity and induce long-term immune responses in nonhuman primates.
Choosing — or starting treatment with — manual therapy over opioid medications for the management of spine or shoulder may result in lower associated downstream costs.
By 2030, robots will likely replace 800 million workers. Will physicians make the cut?
Investigators sought to determine the association between liver fibrosis and hepatitis B virus genotype G in patients with comorbid HIV and HBV.
The researchers reported more than 75% of patients achieved complete response after 1 cycle of the intensive chemotherapy regimen.
Postmenopausal women with normal BMI and elevated body fat levels are at increased risk of breast cancer.
Certain chemicals used in personal care and household products were found to cause early puberty in adolescent girls.
Sexual minority youths have a significantly higher risk for life-threatening behavior compared with their heterosexual peers.
Oxybutynin, an anticholinergic used to treat urinary incontinence, may provide breast cancer survivors with an alternative treatment option for hot flashes, according to new research.
The "Christmas Effect" has been linked to increased risks in patients discharged from the hospital during the December holiday season.
Spices, herbal remedies, and ceremonial powders may contain lead and contribute to elevated blood lead levels among exposed children.
Women born during the Chinese famine period may be at increased risk for early natural menopause and premature ovarian failure.
Is there an association between breast cancer risk and recent childbirth?
A pair of new case-finding strategies may help general practitioners identify and refer patients and survivors of ovarian cancer to genetic counseling and DNA testing.
Omalizumab rescue therapy produced rapid results in a patient with refractory status asthmaticus.
An intervention by community pharmacists consisting of sending elderly patients educational information on deprescribing of inappropriate medications resulted in higher levels of discontinuation of inappropriate medications within 6 months compared with those in patients who received usual care.
The Advisory Committee on Immunization Practices Hepatitis Vaccines Work Group has updated recommendations for hepatitis A vaccination for PEP and PrEP.
Those with HCV genotype 1 with recent injection drug use and/or current opioid substitution therapy, paritaprevir/ritonavir, ombitasvir, and dasabuvir with/without ribavirin is effective.
Health information is widely available online, yet the quality of that information can be dubious at best.
Members of 2 remote Venezuelan tribes were found to have elevated blood pressure following exposure to Western culture.
The first successful case of a live birth following uterine transplantation from a deceased donor was reported at the São Paulo School of Medicine, Brazil.
Nurse staffing ratios and subjective workload were found to be directly associated with missed care in a NICU.
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Clinical Advisor Articles
- Epilepsy, Sleep Apnea, and SUDEP: A Closer Look
- Vitamin D3 Associated With Reductions in Migraine Days Among Migraineurs
- Study Finds Cottonseed Oil Better Than Olive Oil at Improving Cholesterol Profiles, Triglyceride Levels
- Actinic Keratoses: Field Cancerization and Photodynamic Therapy
- Health Experts Review 41 Diets, Rank Best Overall for 2019
- WHO Names Anti-Vax Top Health Threat: Hysteresis May Describe Movement
- Temporary Impairment in HRQOL After Teen Sports Concussion
- GI Illness, Hospitalization Increase, Symptom Reports Decrease Among Older Adults
- High Levels of Activity, Motor Ability Linked to Better Cognition
- Complications Higher Than Expected for Invasive Lung Tests