More primary care practices have been making medical records, including clinical notes, available to patients via secure electronic portals.
Talzenna, a poly (ADP-ribose) polymerase (PARP) inhibitor, was evaluated in EMBRACA, an open-label trial that randomized patients with gBRCAm HER2-negative locally advanced or metastatic breast cancer (N=431) to receive talazoparib 1mg or physician's choice of chemotherapy (capecitabine, eribulin, gemcitabine, or vinorelbine).
The expanded approval was supposed by safety and efficacy data from the Phase 3 ACCESS IUS trial (N=1751) in women receiving Liletta. In the trial, Liletta demonstrated >99% efficacy in preventing pregnancy for up to 5 years in a broad patient population.
The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.
The effect of high-intensity interval training with a bout of moderate-intensity continuous training on glucose levels was examined in T1D.
Investigators examine the effect of a low-fat, plant-based diet on insulin resistance and body composition.
The use of β-blockers in the first trimester of pregnancy may not greatly increase the risk for major congenital malformations in offspring.
A 7-item pain intensity measure for persons with dementia has shown initial validity and reliability.
The burden of childhood and infant pneumonia can be effectively reduced through the use of the pneumococcal Haemophilus influenzae protein D conjugate vaccine.
The consumption of dietary gluten was not associated with microscopic colitis risk in patients without celiac disease.
Higher Levels of Anti-CA15.3 and Anti-CA125 Linked to Increased Risk for Mucinous Epithelial Ovarian Cancer
Researchers used the EPIC Cohort to identify whether anti-CA125 and anti-CA15.3 antibodies alone or in combination with antigens may determine epithelial ovarian cancer risk.
Among cancer survivors, illness perception may affect patient health-related quality of life and mortality.
Although ovarian cancer risk may be reduced with regular use of low-dose aspirin, the use of nonaspirin analgesics may increase the risk of ovarian cancer among long-term, high-quantity users.
AAPA and NCCPA partner in a national advertising campaign to raise awareness of the PA profession.
Researchers analyze the dietary habits of 260 patients in the early stages of multiple sclerosis from baseline to 5 years after initial onset of symptoms.
For this analysis, the authors used follow-up data from all 7020 patients included in the EMPA-REG OUTCOME trial to estimate the effect of empagliflozin on all-cause mortality vs placebo over the duration of a patient's lifetime.
The study authors searched MEDLINE from inception through July 2018 to obtain relevant cohort studies and randomized trials assessing HBVr incidence secondary to pharmaceutical agents.
Study authors at the American College of Gastroenterology (ACG) Scientific Meeting 2018 presented late-breaking data from the induction phase of the Phase 3 UNIFI study.
The quality of patient monitoring may improve if the clinical practice guidelines are improved, as many healthcare professionals use the guidelines in their monitoring of patients taking lithium.
The Get With the Guidelines-Stroke program includes measures such as neurologist assessment, rehabilitation evaluation, and education on stroke risk factors.
An outbreak of flea-borne typhus in Los Angeles County has so far resulted in 57 cases, including 20 in Pasadena and 9 in downtown Los Angeles.
The test works by measuring levels of anti-cytolethal distending toxin B (CdtB) and anti-vinculin, 2 biomarkers of post-infectious IBS-D and IBS-M.
Safety data for Fycompa was consistent with the safety profile in adult populations without the need for weight-based dosing.
The new guidelines place a substantial emphasis on the importance of introducing high-quality rehabilitation early in these patients.
The approval of the expanded age range was based on data from a clinical trial which evaluated the efficacy of Gardasil (quadrivalent human papillomavirus recombinant vaccine) in 3253 women 27-45 years of age with a median duration of follow-up of 3.5 years post-dose 3.
One of the goals of the US Department of Health and Human Services National Viral Hepatitis Action Plan is to eliminate mother-to-infant transmission of HCV infection.
The petition was submitted by a number of non-profit organizations including the Center for Science in the Public Interest and the Breast Cancer Fund.
Investigators examined treatment response of sofosbuvir-based DAA in patients with chronic hepatitis C with compensated liver cirrhosis in a community care setting.
The Company states that the NDA is supported by robust clinical trial data, including patients studies where more than 1600 seizures were treated with Valtoco nasal spray.
Wide variations in influenza vaccine coverage have been noted across healthcare personnel based on occupation and worksite.
The odds of language delay were lower at 18 months and 36 months in children exposed to AEDs in utero whose mothers took folic acid.
The risk for late-onset epilepsy was lower in patients with higher physical activity levels and moderate alcohol intake.
Recurrence of seizures was reported in 28.2% of patients who attempted withdrawal.
Weight loss may indicate a cancer diagnosis in patients presenting in primary care, specifically when weight loss correlates to another cancer-related clinical feature.
Analysis of 2 phase 3 clinical trials evaluating the safety/efficacy of glecaprevir/pibrentasvir in people with HCV coinfected with HIV-1 found an overall sustained virologic response of 98% at week 12 of treatment in those with or without cirrhosis.
Approximately 28% of stroke patients have diabetes, and the presence of diabetes can increase the risk for poor stroke outcome.
Active Choice Intervention Effective in Increasing Influenza Vaccination Rates at Primary Care Practices
Influenza vaccination rates decline as the clinic day progresses.
Screening of adult patients with significant depressive symptoms is often inadequate in the primary care setting, especially among those with hazardous alcohol consumption.
New data suggest an association between general practitioners' prescribing habits for urinary tract infections and UTI-related E coli bacteremia incidence.
For patients with CAP, antibiotic regimens including a fluoroquinolone may reduce mortality risk by 1-2% compared to beta-lactams and cephalosporins alone.
In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection
A combination single tablet once-a-day regimen of doravirine/lamivudine/tenofovir disoproxil fumarate demonstrated non-inferiority and no significant adverse events when compared with continuation of established antiretroviral therapy in adults infected with HIV-1.
Women with ovarian or endometrial cancer who adhere to a ketogenic diet may benefit from a selective loss of fat mass and a reduction in fasting serum insulin, while still retaining lean mass.
Changes in allergy records were suggested by the allergy service consult for 62% of the patients.
Both doses will be supplied in single-dose, prefilled syringes for manual injection.
For women at high risk for cystitis recurrence who drink low volumes of fluid daily, increasing water intake prevents recurrence.
A documented β -lactam allergy was found in more than one-third of patients receiving broad-spectrum antibiotics, however, only 10% of patients were found to be truly allergic.
The use of a moderate to low susceptibility antibiotic to treat a urinary tract infection [UTI] may result in a 1.74-fold increase in the odds of an emergency department readmission within 30 days for another UTI.
Monovalent Acellular Pertussis Vaccine Safe and Effective for Neonates With Mothers Unvaccinated for Tdap
The monovalent acellular pertussis vaccine may be beneficial to neonates whose mothers did not receive Tdap vaccine during pregnancy.
Hypertensive disorders of pregnancy and gestational diabetes may increase the risk for hot flashes during menopause.
Women who were exposed to sexual harassment and/or assault were found to experience higher blood pressure, poorer sleep, and mood changed that can affect mental health.
Patients undergoing robotic hysterectomy were found to report comparable pain scores when receiving celecoxib perioperatively or ketorolac postoperatively.
A case and commentary published in the AMA Journal of Ethics discusses the ethics of primary care physician response to direct-to-consumer genetic testing results of concerned patients.
Light treatments successfully corrected abnormal timing of melatonin circadian rhythms in perimenopausal women with depression and improved mood and sleep within 2 weeks.
For certain patients with endocarditis on the left side of the heart under stable condition, switching from intravenous (IV) antibiotics to orally administered antibiotics is noninferior to staying on IV treatment.
The recent Supreme Court decision on crisis pregnancy centers is expected to complicate the future of some health laws.
The upper level of vitamin D recommended by the Endocrine Society can result in frequent hypercalciuria.
Barriers found among PCPs in surveillance of HCC indicate the need for clinical interventions, including provider education.
Emergency department computed tomography rates for children with minor head trauma were not affected by parent decision aid use.
Talazoparib, a poly(adenosine diphosphate-ribose) inhibitor, may significantly enhance progression-free survival in patients with advanced breast cancer and a germline BRCA1/2 mutation.
These findings suggest an increased risk for postpartum depressive symptoms in mothers with gestational diabetes, independent of depressive symptomatology during pregnancy.
Teens whose concern over societal discrimination grew between 2016 and 2017 increased their cigarette and marijuana use.
Continuous positive airway pressure for obstructive sleep apnea in patients with type 2 diabetes offered no improvement in visual acuity compared with usual care alone.
In one study, 86% of patients clinically diagnosed with esophagopharyngeal reflux reported significant reduction in symptoms after 2 weeks of use.
Management of alcohol abuse, suicidal ideation or behavior, and manic symptoms may reduce aggression among patients with bipolar disorder with psychotic features.
From 2008 to 2015, both cervical intraepithelial neoplasia grades 2, 3 and adenocarcinoma in situ rates and cervical cancer screening declined in women age 18 to 24 years.
A combined immunosuppressive regimen was found to be a highly effective and safe treatment for patients with type B insulin resistance.
More than 2 hours of recreational screen time was found to be associated with cognitive decline in children.
The Centers for Disease Control and Prevention's "Guideline for Prescribing Opioids for Chronic Pain" may have contributed to a further reduction in several opioid prescribing practices.
Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.
Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.
"Moral norms" in the medical domain must be applied to pregnant women and their physicians.
This research rejects any association between increased risk for ADHD and changes in children's microbiota related to cesarean delivery or antibiotic use.
SGLT-2i exhibited superior effects in terms of weight loss and did not increase the risk for hypoglycemia in dual therapy with sulfonylurea.
The use of corticosteroids in sepsis appears to modestly reduce the risk for death and modestly increase neuromuscular weakness but the evidence is not definitive.
The FDA based its approval on the results of a triplet of phase 3 studies, the MONALEESA-2, MONALEESA-3, and MONALEESA-7.
In Case 1, a 24-year-old woman presents to the clinic with a 4-month history of an erythematous annular lesion on the dorsal arm. In Case 2, a 47-year-old non-Hispanic white woman presents to the clinic with a history of a chest lesion for several years. Can you diagnose these conditions?
Total omega-3 and omega-6 plasma polyunsaturated fatty acids relative abundances were significantly inversely correlated with asthma/recurrent wheeze and allergic sensitization.
High population immunity is an indicator of the decline in serotype 2 Sabin vaccine poliovirus after serotype 2 oral poliovirus vaccine withdrawal.
For this phase 1b study, researchers enrolled 57 patients with ERBB2/HER2-positive metastatic breast cancer previously treated with trastuzumab and a taxane.
Before you sign on the dotted line, take these steps to ensure you are compensated fairly.
Researchers created a 3-part online survey to assess the knowledge, attitudes, and barriers of primary care providers and gynecologists regarding vulvovaginal atrophy.
Investigators examined the effects of smoking on respiratory symptoms and functional levels in patients with multiple sclerosis.
Use of serotonin reuptake inhibitors for maternal depression may increase the risk for low birth weight in children.
Levels of p,p'-DDE were higher in mothers of children with autism than in mothers of children in the control group.
High-dose folic acid supplementation beyond the first trimester does not prevent pre-eclampsia in high-risk women.
Including Hypertensive Disorders of Pregnancy in CVD Risk Score Does Not Improve CVD Risk Prediction
Adding history of hypertensive disorders of pregnancy to the current cardiovascular disease (CVD) risk score does not improve CVD prediction in low-risk women.
Researchers concluded that physical activity was not associated with risk for early menopause.
Although 2 patients experienced an increase in seizure frequency, the remaining patients did not experience a change in frequency.
Repeated exposure to high levels of HbA1c was associated with increased risk for dementia in a cohort of patients age ≥50 with type 1 diabetes.
Children born by cesarean delivery who were large for gestational age and had low Apgar scores may be at increased risk of developing a food allergy.
Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.
Intensive blood pressure therapy is associated with a significantly lower risk for serious cardiovascular events in the adults with diabetes.
The North American Menopause Society has found that postmenopausal women with a breast cancer diagnosis may have vitamin D deficiency as well as higher rates of obesity.
As infections from drug-resistant microbes continue to rise, the development of new antibiotics has declined since the golden age of antibiotic discovery in the mid-20th century.
This effort is in response to epinephrine auto-injector supply issues reported by manufacturers to the Food and Drug Administration (FDA).
Whole-exome sequencing revealed that PALB2, ATM, CHEK2, and MSH6 genes were significantly associated with an increased risk of breast cancer; MSH6, RAD51C, TP53, and ATM were found to be linked to an increased risk of ovarian cancer.
Intraductal papillary mucinous neoplasms and numerous gastrointestinal tumors have been linked to somatic gain-of-function GNAS mutations, which can lead to McCune-Albright syndrome.
The USPSTF recommends that clinicians refer adults with a body mass index of 30 or higher to intensive, multicompetent behavioral interventions.
Curing HCV infection with direct-acting antiretrovirals is associated with regression of liver fibrosis for most patients.
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Clinical Advisor Articles
- Communicating Care via Fax: NP Faulted for Negligence
- AAPA and NCCPA Partner to Campaign for Physician Assistant Recognition
- Ovarian Cancer Risk Reduced With Regular, Low-Dose Aspirin
- Microscopic Colitis Risk Not Linked to Dietary Gluten in Women Without Celiac Disease
- FDA Amends Food Additive Regulations to No Longer Allow Use of 7 Substances
- Relationships Between Prescribing for UTI, E coli Bacteremia, Resistance
- Gardasil 9 Approved for Use in Women and Men 27 Through 45 Years Old
- Optimizing Pregnancy Outcomes With Micronutrients
- Reflux Band Now Available OTC for Reducing Laryngopharyngeal Reflux
- Cesarean Delivery Linked to Food Allergy in Offspring
- Patient Perceptions of Clinical Notes at Issue Among Mental Health Providers
- Talzenna Approved for Germline BRCA-Mutated, HER2-Negative Breast Cancer
- Liletta Now Approved for Pregnancy Prevention for Up to 5 Years
- Job Market for Nephrologists Continuing to Improve
- High Risk for Readmission for Takotsubo Syndrome